|Systematic (IUPAC) name|
|Legal status||Rx, PoM|
|Excretion||urine and bile|
| (what is this?)
Nitrofurantoin is an antibiotic which is marketed under the following brand names; Niftran, Furadantin, Furabid, Macrobid, Macrodantin, Nitrofur Mac, Nitro Macro, Nifty-SR, Martifur-MR, Uro-Tablinen or Nifuretten (in Germany), Martifur-100 (in India), Urantoin, Nifuran (in Macedonia) and Uvamin (in Middle East). It is usually used in treating urinary tract infection. It is often used against E. coli.
Resistance to other antibiotics has led to increased interest in this agent.
It is sometimes described as being appropriate to use in pregnant patients (along with other agents such as sulfisoxazole or cephalexin). This is in contrast to agents such as trimethoprim and ciprofloxacin which may not be appropriate for pregnant women.
Organisms are said to be susceptible to nitrofurantoin if their minimum inhibitory concentration (MIC) is 32 μg/mL or less. The peak blood concentration of nitrofurantoin following an oral dose of nitrofurantoin 100 mg, is less than 1 μg/mL and may be undetectable; tissue penetration is negligible; the drug is well concentrated in the urine: 75% of the dose is rapidly metabolised by the liver, but 25% of the dose is excreted in the urine unchanged, reliably achieving levels of 200 μg/ml or more. For this reason, nitrofurantoin cannot be used to treat anything other than simple cystitis although the patient information leaflet states it is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract.
At the concentrations achieved in urine (>100 microgm/mL), nitrofurantoin is bacteriocidal. It is bacteriostatic against most susceptible organisms at concentrations less than 32 micrograms per milliliter.
Nitrofurantoin and the quinolone antibiotics are mutually antagonistic in vitro. It is not known whether this is of clinical significance, but the combination should be avoided.
Resistance to nitrofurantoin may be chromosomal or plasmid mediated and involves inhibition of nitrofuran reductase. Acquired resistance in E. coli continues to be rare.
Nitrofurantoin and its metabolites are excreted mainly by the kidneys. In renal impairment, the concentration achieved in urine may be subtherapeutic. Nitrofurantoin should not be used in patients with a creatinine clearance of 60 mL/min or less. However a retrospective chart review may suggest that nitrofurantoin is not contraindicated in this population.
The mechanism of action of nitrofurantoin is unique and complex. The drug works by damaging bacterial DNA, since its reduced form is highly reactive. This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins (nitrofuran reductase) to multiple reactive intermediates that attack ribosomal proteins, DNA, respiration, pyruvate metabolism and other macromolecules within the cell. Nitrofurantoin exerts greater effects on bacterial cells than mammalian cells because bacterial cells activate the drug more rapidly. It is not known which of the actions of nitrofurantoin is primarily responsible for its bactericidal activity.
Adult doses of nitrofurantoin for a urinary tract infections can be 100 mg two times daily, or 50 mg four times daily for seven days. For less severe cases of UTIs, the dosage may be prescribed as shortened to 3 days. The pediatric dose is 5–7 mg/kg/day in four divided doses. or when in 25 mg/5ml oral suspension then pediatric dose is 3 mg/kg/day in four divided doses. Nitrofurantoin should be taken with food, as this improves the absorption of the drug by 45%.
- Coagulase negative staphylococci
- Enterococcus faecalis,
- Staphylococcus aureus,
- Streptococcus agalactiae,
- Citrobacter species, and
- Klebsiella species,
and is used in the treatment of infections caused by these organisms. Many or all strains of the following are resistant to nitrofurantoin:
- Enterobacter species
- Klebsiella species
- Acinetobacter species,
- Morganella species,
- Proteus species,
- Providentia species,
- Serratia species,
- Pseudomonas species.
||This article appears to contradict the article Chronic_bacterial_prostatitis. (November 2013)|
, renal abscess, and pyeloempyema because of extremely poor tissue penetration and low blood levels, although the patient information leaflet states it is used to prevent and treat infections of the bladder, kidney and other parts of the urinary tract. Urinary catheter infections may be treated with nitrofurantoin if there are no systemic features; the catheter must be changed after 48 hours of antibiotics and treatment is ineffective if the catheter is not replaced or removed.
The most common side effects with nitrofurantoin are nausea, vomiting, and diarrhea; less common reactions include fever, chills, and various other hypersensitivity reactions. It can also cause pulmonary fibrosis and Drug-induced autoimmune hepatitis. All these side effects are much more common in the elderly hence this antibiotic is strongly not recommended for older adults according to 2012 AGS Beers Criteria.
Many people report tingling and numbness in the arms and legs after only a few days of use (please see here:) - and this tingling and numbness doesn't go away for weeks or sometimes even months after treatment is discontinued. According to an article in the Australian and New Zealand Journal of Medicine, the neuropathy is not dose-related and not necessarily associated with abnormal renal function. Sometimes the nerve damage is irreversible - in one study that was described back in the 1950s, a middle aged lady was left unable to walk and even stand independently after taking this drug to prevent recurrent urinary tract infections.
There are also reports of severe and fatal cases of liver failure  and lung problems  associated with this drug. The British Medical Journal reported in 1982 that "the Swedish drug regulatory authorities receive more reports of adverse reactions to nitrofurantoin than to any other drug"  and in another article, that looked at 921 adverse reactions to nitrofurantoin, three Swedish professors reported that in 71 percent of cases, the reactions were severe enough for patients to be hospitalized, and one percent of the cases were fatal. They concluded that "The time has come for a re-evaluation of nitrofurantoin and its role in the treatment of urinary tract infections." 
Patients should be informed that nitrofurantoin colours urine brown; this is completely harmless.
Neonates (babies up to the age of one month) have immature enzyme systems in their red blood cells (glutathione instability) and nitrofurantoin must therefore not be used because it can cause haemolytic anaemia. For the same reason, nitrofurantoin should not be given to pregnant women after 38 weeks of pregnancy, or who are about to give birth.
Nitrofurantoin is contraindicated in patients with decreased renal function (CrCl < 60mL/min) due to systemic accumulation and subtherapeutic levels reached in the urinary tract. However, a retrospective chart review may suggest that nitrofurantoin is not contraindicated in this population.
Use in animal feed - Unwanted in human food
Residues from the breakdown of nitrofuran veterinary antibiotics, including nitrofurantoin, have been found in chicken in Vietnam, China, Brazil, and Thailand. The European Union banned the use of nitrofurans in food producing animals by classifying it in ANNEX IV (list of pharmacologically active substances for which no maximum residue limits can be fixed) of the Council Regulation 2377/90. The Food and Drug Administration (FDA) of the United States has prohibited furaltadone since February 1985 and withdrew the approval for the other nitrofuran drugs (except some topical uses) in January 1992. The topical use of furazolidone and nitrofurazone was prohibited in 2002. Australia prohibited the use of nitrofurans in food production in 1992. Japan did not allocate MRLs for nitrofurans leading to the implementation of a "zero tolerance or no residue standard". In Thailand, the Ministry of Health issued in 2001 Proclamation No. 231 MRL of veterinary drug in food which did not allocate MRL for nitrofurans. The Ministry of Agriculture and Cooperatives had already prohibited importation and use of furazolidone and nitrofurazone in animal feed in 1999 which was extended to all nitrofurans in 2002. Several metabolites of nitrofurans, such as furazolidone, furaltadone and nitrofurazone cause cancer or genetic damage in rats.
Nitrofurantoin should be taken with food to improve its absorption. Nitrofurantoin is contraindicated in patients with glucose-6-phosphate dehydrogenase deficiency because of risk of intravascular hemolysis resulting in anemia.
- Furadantin (U.S., UK)
- Macrobid (long acting preparation for twice daily dosing available in U.S., Canada, and UK)
- Macrodantin (U.S., UK)
- Uro-Tablinen, Furadantin, Nifuretten, Nifurantin, Urodin (GER, A, CH)
- Macrodantina (Mexico)
- Furatin, Niftran(by Ranbaxy), Niftas(by Intas Pharmaceuticals) (India)
- Uvamin (Middle East)
- Parrott, E. L.; Matheson Jr, L. E. (1977). "Rectal absorption of nitrofurantoin". Journal of Pharmaceutical Sciences 66 (7): 955–958. doi:10.1002/jps.2600660713. PMID 886458.
- Garau J (January 2008). "Other antimicrobials of interest in the era of extended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline". Clin. Microbiol. Infect. 14 Suppl 1: 198–202. doi:10.1111/j.1469-0691.2007.01852.x. PMID 18154548.
- Lee M, Bozzo P, Einarson A, Koren G (June 2008). "Urinary tract infections in pregnancy". Can Fam Physician 54 (6): 853–4. PMC 2426978. PMID 18556490.
- "Urinary Tract Infections During Pregnancy - February 1, 2000 - American Academy of Family Physicians".
- Gilman, eds.: Joel G. Hardman, Lee E. Limbird ; consul. ed.: Alfred Goodman (2002). Goodman & Gilman's the Pharmacological Basis of Therapeutics. (12th ed. ed.). New York: McGraw-Hill. pp. Chapter 52. ISBN 0071354697.
- McCalla DR, Kaiser C, Green MHL (1978). "Genetics of nitrofurazone resistance in Escherichia coli". J Bacteriol 133: 10–16.
- Bains A, Buna D, Hoag NA (2009). "A retrospective review assessing the efficacy and safety of nitrofurantoin in renal impairment". Canadian Pharmacists Journal 142 (5): 248–252. doi:10.3821/1913-701X-142.5.248.
- Tu Y, McCalla DR (1975). "Effect of activated nitrofurans on DNA,". Biochem Biophys Acta 402: 142–49.
- "Complementary and Alternative Medicine Index (CAM)". Umm.edu. Retrieved 2012-05-29.
- "Furadantin 25mg/5ml Oral Suspension OR Nitrofurantoin 25mg/5ml Oral Suspension - Summary of Product Characteristics (SPC) - (eMC)". Medicines.org.uk. 2010-11-18. Retrieved 2012-05-29.
- Richards WA, et al. (1955). "Nitrofurantoin: Clinical and laboratory studies in urinary tract infections". Arch Intern Med 96 (4): 437–50. doi:10.1001/archinte.1955.00250150011001. PMID 13257939.
- Goemaere NN, Grijm K, van Hal PT, den Bakker MA (2008). "Nitrofurantoin-induced pulmonary fibrosis: a case report". J Med Case Reports 2: 169. doi:10.1186/1752-1947-2-169. PMC 2408600. PMID 18495029.
- Björnsson, E; Talwalkar, J; Treeprasertsuk, S; Kamath, PS; Takahashi, N; Sanderson, S; Neuhauser, M; Lindor, K (June 2010). "Drug-induced autoimmune hepatitis: clinical characteristics and prognosis.". Hepatology (Baltimore, Md.) 51 (6): 2040–8. doi:10.1002/hep.23588. PMID 20512992. Retrieved 7 September 2012.
- FAO: Nitrofuran study
- drugs.com for Macrodantin
- Meds-Help.com for nitrofurantoin side effects, interactions and information
- RxList for Macrobid (Nitrofurantoin)