Ornidazole is a drug that cures some protozoan infections. It is used by the poultry industry.
It has been investigated for use in Crohn's disease after bowel resection.[1]
[edit] References
Dosage Adult: PO Amoebiasis 0.5 g twice daily for 5-10 days. Amoebic dysentery 1.5 g once daily for 3 days.Giardiasis 1-1.5 g once daily for 1-2 days. Trichomoniasis 1.5 g once daily for 5 days. Treat sexual partners concomitantly. IV Severe amoebic dysentery; Amoebic liver abscess Initial: 0.5-1 g, then 0.5 g 12 hrly for 3-6 days. Anaerobic bacterial infections Initial: 0.5-1 g, then 1 g/day in 1-2 divided doses for 5-10 days. Substitute w/ 500 mg 12 hrly PO as soon as possible. Surgical prophylaxis 1 g 30 mins pre-op. Click to view ornidazole Dosage by Indications
Contraindications Hypersensitivity to ornidazole or to other nitroimidazole derivatives. Special Precautions Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation. Adverse Drug Reactions Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions. Drug Interactions Potentiates effect of coumarin-type oral anticoagulants. Prolongs the muscle-relaxant effect of vecuronium bromide. Mechanism of Action For details of the mechanism of action, pharmacology and pharmacokinetics and toxicology ... click to view ornidazole
Class Antibiotics / Antiamoebics
Classification - ornidazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections. - ornidazole ; Belongs to the class of imidazole derivative antibacterials. Used in the systemic treatment of infections. - ornidazole ; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
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