Oosterhout is mentioned for the first time in 1277, although archaeological excavations showed the existence of human settlements in the area in prehistoric times. The Knights Templar had a temple here dedicated to St. John the Baptist. It was home to a castle which later acquired control over the surrounding area, up to Breda and Bergen op Zoom. The castle was destroyed by Spanish troops during the Eighty Years War, in 1573; only a tower of it survives today.
The city became the seat of a flourishing ceramics industry, which lasted until the 19th century. In 1625 the city was besieged by Frederick Henry, Prince of Orange, and suffered heavy damage.
Unfinished basilica of St. John. A Romanesque church existed in 1277, but from around 1473 it was rebuilt in the current Gothic style, being finished in 1493. The tower was constructed from 1519 to 1552. It was restored several times in the following centuries.
Monastery of St. Catherine, once a castle held by the Knights Hospitaller.