PLD2

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Phospholipase D2
Identifiers
Symbol PLD2
External IDs OMIM602384 MGI892877 HomoloGene55672 ChEMBL: 2734 GeneCards: PLD2 Gene
EC number 3.1.4.4
RNA expression pattern
PBB GE PLD2 209643 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5338 18806
Ensembl ENSG00000129219 ENSMUSG00000020828
UniProt O14939 P97813
RefSeq (mRNA) NM_001243108 NM_008876
RefSeq (protein) NP_001230037 NP_032902
Location (UCSC) Chr 17:
4.71 – 4.73 Mb
Chr 11:
70.54 – 70.56 Mb
PubMed search [1] [2]

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.[1][2]

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM][3]

Interactions[edit]

PLD2 has been shown to interact with BIN1,[4] Amphiphysin,[4] Aldolase A,[5] PLCG1,[6] ARF1,[7][8] Src,[9] PRKCD,[10] Glyceraldehyde 3-phosphate dehydrogenase,[11] Caveolin 1,[12][13] and Wiskott-Aldrich syndrome protein.[14]

Inhibitors[edit]

  • N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 nM.[15]

References[edit]

  1. ^ Park SH, Ryu SH, Suh PG, Kim H (February 1999). "Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization". Cytogenet Cell Genet 82 (3–4): 225. doi:10.1159/000015106. PMID 9858823. 
  2. ^ Lopez I, Arnold RS, Lambeth JD (June 1998). "Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2". J Biol Chem 273 (21): 12846–52. doi:10.1074/jbc.273.21.12846. PMID 9582313. 
  3. ^ "Entrez Gene: PLD2 phospholipase D2". 
  4. ^ a b Lee, C; Kim S R; Chung J K; Frohman M A; Kilimann M W; Rhee S G (June 2000). "Inhibition of phospholipase D by amphiphysins". J. Biol. Chem. (UNITED STATES) 275 (25): 18751–8. doi:10.1074/jbc.M001695200. ISSN 0021-9258. PMID 10764771. 
  5. ^ Kim, Jong Hyun; Lee Sukmook; Kim Jung Hwan; Lee Taehoon G; Hirata Masato; Suh Pann-Ghill; Ryu Sung Ho (March 2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain". Biochemistry (United States) 41 (10): 3414–21. doi:10.1021/bi015700a. ISSN 0006-2960. PMID 11876650. 
  6. ^ Jang, Il Ho; Lee Sukmook, Park Jong Bae, Kim Jong Hyun, Lee Chang Sup, Hur Eun-Mi, Kim Il Shin, Kim Kyong-Tai, Yagisawa Hitoshi, Suh Pann-Ghill, Ryu Sung Ho (May 2003). "The direct interaction of phospholipase C-gamma 1 with phospholipase D2 is important for epidermal growth factor signaling". J. Biol. Chem. (United States) 278 (20): 18184–90. doi:10.1074/jbc.M208438200. ISSN 0021-9258. PMID 12646582. 
  7. ^ Lee, S; Park J B; Kim J H; Kim Y; Kim J H; Shin K J; Lee J S; Ha S H; Suh P G; Ryu S H (July 2001). "Actin directly interacts with phospholipase D, inhibiting its activity". J. Biol. Chem. (United States) 276 (30): 28252–60. doi:10.1074/jbc.M008521200. ISSN 0021-9258. PMID 11373276. 
  8. ^ Park, J B; Kim J H; Kim Y; Ha S H; Yoo J S; Du G; Frohman M A; Suh P G; Ryu S H (July 2000). "Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner". J. Biol. Chem. (UNITED STATES) 275 (28): 21295–301. doi:10.1074/jbc.M002463200. ISSN 0021-9258. PMID 10801846. 
  9. ^ Ahn, Bong-Hyun; Kim Shi Yeon; Kim Eun Hee; Choi Kyeong Sook; Kwon Taeg Kyu; Lee Young Han; Chang Jong-Soo; Kim Myung-Suk; Jo Yang-Hyeok; Min Do Sik (May 2003). "Transmodulation between phospholipase D and c-Src enhances cell proliferation". Mol. Cell. Biol. (United States) 23 (9): 3103–15. doi:10.1128/MCB.23.9.3103-3115.2003. ISSN 0270-7306. PMC 153190. PMID 12697812. 
  10. ^ Han, Jung Min; Kim Jae Ho, Lee Byoung Dae, Lee Sang Do, Kim Yong, Jung Yon Woo, Lee Sukmook, Cho Wonhwa, Ohba Motoi, Kuroki Toshio, Suh Pann-Ghill, Ryu Sung Ho (March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol. Chem. (United States) 277 (10): 8290–7. doi:10.1074/jbc.M108343200. ISSN 0021-9258. PMID 11744693. 
  11. ^ Kim, Jung Hwan; Lee Sukmook; Park Jong Bae; Lee Sang Do; Kim Jong Hyun; Ha Sang Hoon; Hasumi Keiji; Endo Akira; Suh Pann-Ghill; Ryu Sung Ho (June 2003). "Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells". J. Neurochem. (England) 85 (5): 1228–36. doi:10.1046/j.1471-4159.2003.01755.x. ISSN 0022-3042. PMID 12753082. 
  12. ^ Zheng, Xiangjian; Bollinger Bollag Wendy (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation". J. Invest. Dermatol. (United States) 121 (6): 1487–95. doi:10.1111/j.1523-1747.2003.12614.x. ISSN 0022-202X. PMID 14675200. 
  13. ^ Czarny, M; Fiucci G; Lavie Y; Banno Y; Nozawa Y; Liscovitch M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains". FEBS Lett. (NETHERLANDS) 467 (2–3): 326–32. doi:10.1016/S0014-5793(00)01174-1. ISSN 0014-5793. PMID 10675563. 
  14. ^ Kantonen, S; Hatton N; Mahankali M; Henkels K M; Park H; Cox D; Cambronero J (November 2011). "A Novel Phospholipase D2-Grb2-WASp Heterotrimer Regulates Leukocyte Phagocytosis in a Two-Step Mechanism.". Mol Cell Biol (UNITED STATES) 31 (22): 4524–37. doi:10.1128/MCB.05684-11. PMC 3209255. PMID 21930784. 
  15. ^ Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW (September 2010). "Design, Synthesis, and Biological Evaluation of Halogenated N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor". J. Med. Chem. 53 (18): 6706–19. doi:10.1021/jm100814g. PMC 3179181. PMID 20735042. 

Further reading[edit]