Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. PKCD is also regulated by phosphorylation on various tyrosine residues including Y311 (by SRC).
^Huppi K, Siwarski D, Goodnight J, Mischak H (June 1994). "Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14". Genomics19 (1): 161–2. doi:10.1006/geno.1994.1028. PMID8188219.
^Hodgkinson, Conrad P; Sale Graham J (January 2002). "Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment". Biochemistry (United States) 41 (2): 561–9. doi:10.1021/bi010719z. ISSN0006-2960. PMID11781095.
^Kristof, Arnold S; Marks-Konczalik Joanna, Billings Eric, Moss Joel (September 2003). "Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin". J. Biol. Chem. (United States) 278 (36): 33637–44. doi:10.1074/jbc.M301053200. ISSN0021-9258. PMID12807916.
^Yoshida, K; Kufe D (December 2001). "Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C delta in response to DNA damage". Mol. Pharmacol. (United States) 60 (6): 1431–8. ISSN0026-895X. PMID11723252.
^Ren, Jian; Li Yongqing, Kufe Donald (May. 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling". J. Biol. Chem. (United States) 277 (20): 17616–22. doi:10.1074/jbc.M200436200. ISSN0021-9258. PMID11877440.
^Kumar, V; Pandey P, Sabatini D, Kumar M, Majumder P K, Bharti A, Carmichael G, Kufe D, Kharbanda S (March 2000). "Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap-dependent initiation of translation". EMBO J. (ENGLAND) 19 (5): 1087–97. doi:10.1093/emboj/19.5.1087. ISSN0261-4189. PMC305647. PMID10698949.
^Brodie, Chaya; Steinhart Rivka, Kazimirsky Gila, Rubinfeld Hadara, Hyman Tehila, Ayres Jolene N, Hur Gang Min, Toth Attila, Yang Dazhi, Garfield Susan H, Stone James C, Blumberg Peter M (July 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Mol. Pharmacol. (United States) 66 (1): 76–84. doi:10.1124/mol.66.1.76. ISSN0026-895X. PMID15213298.
^Braiman, L; Alt A, Kuroki T, Ohba M, Bak A, Tennenbaum T, Sampson S R (April 2001). "Insulin induces specific interaction between insulin receptor and protein kinase C delta in primary cultured skeletal muscle". Mol. Endocrinol. (United States) 15 (4): 565–74. doi:10.1210/me.15.4.565. ISSN0888-8809. PMID11266508.
^Rosenzweig, Tovit; Braiman Liora, Bak Asia, Alt Addy, Kuroki Toshio, Sampson Sanford R (June 2002). "Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling". Diabetes (United States) 51 (6): 1921–30. doi:10.2337/diabetes.51.6.1921. ISSN0012-1797. PMID12031982.
^Storz, P; Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, Johannes F J (August 2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. (UNITED STATES) 275 (32): 24601–7. doi:10.1074/jbc.M002964200. ISSN0021-9258. PMID10831594.
^Han, Jung Min; Kim Jae Ho, Lee Byoung Dae, Lee Sang Do, Kim Yong, Jung Yon Woo, Lee Sukmook, Cho Wonhwa, Ohba Motoi, Kuroki Toshio, Suh Pann-Ghill, Ryu Sung Ho (March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells". J. Biol. Chem. (United States) 277 (10): 8290–7. doi:10.1074/jbc.M108343200. ISSN0021-9258. PMID11744693.
^Phillips-Mason PJ, Kaur H, Burden-Gulley SM, Craig SE, Brady-Kalnay SM (2011). "Identification of Phospholipase C gamma1 as a Protein Tyrosine Phosphatase mu Substrate that Regulates Cell Migration". J Cell Biochem112 (1): 39–48. doi:10.1002/jcb.22710. PMC3031780. PMID20506511.