Spectinomycin: Difference between revisions

Spectinomycin
Clinical data

ATC code	J01XX04 (WHO)
Identifiers
IUPAC name (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)- 4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino) decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
CAS Number	1695-77-8
PubChem CID	15541
DrugBank	APRD01232
CompTox Dashboard (EPA)	DTXSID9023592
ECHA InfoCard	100.015.374
Chemical and physical data
Formula	C₁₄H₂₄N₂O₇
Molar mass	332.35 g/mol g·mol⁻¹

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic produced by the bacterium Streptomyces spectabilis. It is not available in US.

Mechanism

It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.

It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins.

Side effects include itching, chills, stomach-ash, and red rash.

-mycin (Streptomyces)	Streptomycin^# Dihydrostreptomycin Neomycin^# Framycetin Paromomycin^# Ribostamycin Kanamycin Amikacin^# Arbekacin Bekanamycin Dibekacin Tobramycin (+loteprednol) Spectinomycin^# Hygromycin B Totomycin Apramycin Nourseothricin
-micin (Micromonospora)	Gentamicin^# Netilmicin Sisomicin Micronomicin Plazomicin^# Isepamicin Verdamicin Astromicin
other	Butirosin

Tetracyclines	Doxycycline^# Chlortetracycline Clomocycline Demeclocycline Eravacycline Lymecycline Meclocycline^‡ Metacycline Minocycline Omadacycline Oxytetracycline Penimepicycline Rolitetracycline Sarecycline Tetracycline^#
Glycylcyclines	Tigecycline

Amphenicols	Chloramphenicol^# Azidamfenicol Thiamphenicol Florfenicol

Macrolides	Azithromycin^# Boromycin Carbomycin Carrimycin Clarithromycin^# Dirithromycin Erythromycin^# Flurithromycin Gamithromycin Josamycin Kitasamycin Midecamycin Miocamycin Oleandomycin Rokitamycin Roxithromycin Solithromycin Spiramycin Telithromycin Tildipirosin Tilmicosin Troleandomycin Tulathromycin Tylosin Tylvalosin
Ketolides	Telithromycin^‡ Cethromycin Solithromycin^†
Lincosamides	Clindamycin^# Lincomycin Pirlimycin
Streptogramins	Pristinamycin (IA, IIA, IIB) NXL103 (Flopristin, Linopristin) Quinupristin/dalfopristin (Dalfopristin, Quinupristin) Streptogramin A Streptogramin B Virginiamycin (S1)

v t e Antibacterials: others (J01X, D06AX)
Glycopeptides Lipoglycopeptides	Avoparcin Corbomycin Dalbavancin Oritavancin Ristocetin Teicoplanin Telavancin Vancomycin
Polymyxins	Colistin Polymyxin B
Steroid antibacterials	Fusidic acid
Imidazole derivatives	Metronidazole Ornidazole Tinidazole
Pleuromutilins	Azamulin Lefamulin Retapamulin Tiamulin Valnemulin
Nitrofuran derivatives	Furazolidone Nifuroxazide Nifurtoinol Nifurzide Nitrofurantoin Nitrofurazone
Other antibacterials	Bacitracin Clofoctol Daptomycin Fosfomycin Furaltadone Lefamulin Linezolid Mandelic acid Methenamine Nitroxoline Novobiocin Spectinomycin Tedizolid Xibornol

This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it.

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-'''Spectinomycin''' (marketed as the [[hydrochloride]] salt '''spectinomycin hydrochloride''' under the trade name '''Trobicin''') is an [[aminocyclitol]] [[antibiotic]] produced by the [[bacteria|bacterium]] ''[[Streptomyces spectabilis]]''.
+'''Spectinomycin''' (marketed as the [[hydrochloride]] salt '''spectinomycin hydrochloride''' under the trade name '''Trobicin''') is an [[aminocyclitol]] [[antibiotic]] produced by the [[bacteria|bacterium]] ''[[Streptomyces spectabilis]]''.  It is not available in US.
 ==Mechanism==