Fucose: Difference between revisions
fixed alpha 1-6 to proper nomenclature alpha 1,6 |
fixed alpha 1-2 to proper alpha 1,2 terminology |
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In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars.<ref>[[Image:Free_text.png]] {{cite journal| title=The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-<nowiki>[beta]</nowiki>1,3-glucosyltransferase activity from Chinese hamster ovary cells| year=1999| month=July| id=PMID 10362837| url=http://glycob.oxfordjournals.org/cgi/content/full/9/7/679| author=Daniel J. Moloney| coauthors=Robert S. Haltiwanger| journal=Glycobiology| volume=9| pages=679–687}}</ref> |
In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars.<ref>[[Image:Free_text.png]] {{cite journal| title=The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-<nowiki>[beta]</nowiki>1,3-glucosyltransferase activity from Chinese hamster ovary cells| year=1999| month=July| id=PMID 10362837| url=http://glycob.oxfordjournals.org/cgi/content/full/9/7/679| author=Daniel J. Moloney| coauthors=Robert S. Haltiwanger| journal=Glycobiology| volume=9| pages=679–687}}</ref> |
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In human ''N''-linked glycans, fucose is most commonly linked alpha 1,6 to the reducing terminal beta-''N''-acetlyglucosamine. However, fucose at the non-reducing termini linked alpha 1 |
In human ''N''-linked glycans, fucose is most commonly linked alpha 1,6 to the reducing terminal beta-''N''-acetlyglucosamine. However, fucose at the non-reducing termini linked alpha 1,2 to galactose forms the H antigen, the substructure of the A and B blood group antigens. |
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Fucose is metabolized by an enzyme called alpha-[[fucosidase]]. |
Fucose is metabolized by an enzyme called alpha-[[fucosidase]]. |
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Revision as of 02:52, 18 May 2008
Fucose is a hexose deoxy sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian, insect and plant cell surface, and is the fundamental sub-unit of the fucoidan polysaccharide. Alpha1→3 linked core fucose is a suspected carbohydrate antigen for IgE-mediated allergy.[1]
Two structural features distinguish fucose from other six-carbon sugars present in mammals: the lack of a hydroxyl group on the carbon at the 6-position (C-6) and the L-configuration. It is equivalent to 6-deoxy-L-galactose.
In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an attachment point for adding other sugars.[2] In human N-linked glycans, fucose is most commonly linked alpha 1,6 to the reducing terminal beta-N-acetlyglucosamine. However, fucose at the non-reducing termini linked alpha 1,2 to galactose forms the H antigen, the substructure of the A and B blood group antigens.
Fucose is metabolized by an enzyme called alpha-fucosidase.
See also
References
- ^
Daniel J. Becker (2003). "Fucose: biosynthesis and biological function in mammals". Glycobiology. 13: 41R–53R. PMID 12651883. {{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^
Daniel J. Moloney (1999). "The O-linked fucose glycosylation pathway: identification and characterization of a uridine diphosphoglucose: fucose-[beta]1,3-glucosyltransferase activity from Chinese hamster ovary cells". Glycobiology. 9: 679–687. PMID 10362837. {{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help)
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