List of Spider-Man enemies

File:Spider-Man Villains.jpg

The many villains of Spider-Man. Art by Sean Chen.

Spider-Man has one of the best-known rogues galleries in comics, in part because he has been the featured character in more individual titles (Amazing Spider-Man, Spectacular Spider-Man, Marvel Team-Up, Web of Spider-Man, Friendly Neighborhood Spider-Man, and others, many of which were published simultaneously for years) than any other comic book super-hero except for Superman and Batman, giving him a large number of published stories in which to fight a proportionately large number of villains.

Spider-Man's most infamous and dangerous enemies are generally considered to be the Green Goblin, Doctor Octopus, and Venom. Others include the Lizard, Electro, the Hobgoblin, Carnage, the Scorpion, the Vulture, the Sandman, the Rhino, Kraven the Hunter, Mysterio, the Kingpin and the Shocker, among many others. As with Spider-Man, the majority of these villains' powers originate with scientific accidents or the misuse of scientific technology, tend to have animal-themed costumes or powers, and are nearly all male. At times these villains have formed groups such as the Sinister Six to oppose Spider-Man.

Central rogues' gallery

Spider-Man's most renowned rogues include (in alphabetical order):

Villain	First appearance	Description
Beetle	Strange Tales #123 (August, 1964)	Abner Jenkins was a master mechanic at an aircraft parts factory who became dissatisfied with his boring, low paying job. Using his considerable mechanical knowledge, Jenkins built an armor-plated, strength-augmenting suit, a pair of gravity-defying wings, suction-fingered gloves, and a cybernetic control helmet. Calling himself the Beetle, Jenkins decided to use his battle-suit for fame, wealth, and adventure.
Burglar	Amazing Fantasy #15 (August 1962)	Peter Parker's first foe was not one of his more well-known costumed enemies, but rather a common criminal. Small-time burglar plays a pivotal role in Spider-Man's origin. Spider-Man originally intends to use his powers for fame and fortune, but one day he allows a thief to run past him. Soon after, the same criminal broke into his house intending to rob it and, when confronted, shoots and kills Peter's Uncle Ben.
Carnage	Amazing Spider-Man #360 (April 1992)	Carnage is the combination of a symbiote spawned from the original Venom symbiote and the serial killer, and former cell mate of Eddie Brock, Cletus Kasady. He thrives on murder and chaos and is many times stronger than Spider-Man.
Chameleon	Amazing Spider-Man #1 (March 1963)	Chameleon aka Dimitri Smerdyakov was a Russian spy with a knack for disguises.
Doctor Octopus
	Amazing Spider-Man #3 (July 1963)	Dr. Otto Octavius is a respected scientist, one of the world's foremost experts in radiation who used four mechanical arms in his experiments, which bonded with his nervous system after an explosion becoming Doctor Octopus. He combines physical power with mad genius and is a founding member and leader of the Sinister Six.
	Amazing Spider-Man #406 (October 1995)	During the Clone Saga, Dr. Otto Octavius (Doctor Octopus) is killed by Kaine and is replaced not long after by Carolyn Trainer, daughter of Seward Trainer and adoring student of Octavius. She obtains a set of four tentacles identical to Octavius' and made use of a personal force-field that kept anything from hitting her. She took the name Doctor Octopus in honor of her beloved instructor but is later known as Lady Octopus.
Electro	Amazing Spider-Man #9 (February 1964)	An emotionally stunted man with an inferiority complex, Maxwell Dillon is struck by lightning while working on power lines and discovers that he has a supernatural control over electricity. Donning a green and yellow lightning themed costume, he goes on to battle Spider-Man numerous times.
Green Goblin
	Amazing Spider-Man #14 (July 1964)	Originally a normal scientist and ambitious businessman, Norman Osborn uses an experimental formula which gives him superpowers but also drives him insane. When Spider-Man thwarts his plans to take over as crime boss of New York City, he dedicates himself to utterly destroying Spider-Man's life. Their mutual animosity becomes personal when Osborn kills Gwen Stacy, Parker's long-time girlfriend and first true love. He is generally acknowledged to be Spider-Man's arch-nemesis and worst enemy, and also is responsible for the murder of Ben Reilly, the disappearance of Peter Parker's infant daughter, his son Harry's spiral into madness and eventual death, and masterminding the entire Clone Saga.
	Amazing Spider-Man #136 (September 1974)	Harry Osborn, Norman's son and Peter Parker's best friend, eventually dons his father's old costume and continues his mission of hate against Spider-Man after his father's apparent death.
	Amazing Spider-Man #175 (December 1977)	Harry's therapist Bart Hamilton also dons the costume temporarily until he dies.
Hammerhead	Amazing Spider-Man #113 (1972)	Hammerhead is a member of organized crime and is closely associated with the Maggia crime family. Hammerhead distinguishes himself from other villains in that he dresses up and acts like a gangster from the 1920s. Due to an injury he suffers in which his skull is reinforced with metal, his head has a flat shape to it.
Hobgoblin
	Amazing Spider-Man #238 (March 1983)	A millionaire fashion designer and criminal named Roderick Kingsley acquires the Green Goblin's weaponry and uses them to further his own ambitions after the Goblin's seeming death during a battle with Spider-Man. He modifies Osborn's original formula to give himself superhuman strength without becoming insane.
	Amazing Spider-Man #238(September 1983)	Arnold Donovan is a petty thug in the employ of Kingsley who briefly became the Hobgoblin after he was exposed to Norman Osborn's Goblin formula.
	Marvel Team-Up #138 (February 1984)	Kingsley later brainwashes Ned Leeds, a reporter working for the Daily Bugle, to act as a stand in on many occasions and fool the underworld into thinking that Leeds is the Hobgoblin.
	Amazing Spider-Man #289 (June 1987)	Jason Macendale also uses the Hobgoblin identity for a time.
Hydro-Man	Amazing Spider-Man #212 (January 1981)	Morris Bench works on a cargo ship until an accident transforms him into a being of pigmented water, able to control his own liquid body. He has since been a frequent antagonist of Spider-Man and an occasional ally/enemy of the Sandman whom he once accidentally merged with and became a mud monster.
Kingpin	Amazing Spider-Man #50 (July 1967)	Wilson Fisk is the most powerful crime boss in New York City.
Kraven the Hunter
	Amazing Spider-Man #15 (August 1964)	Perhaps the most respected big game hunter in the business, Sergei Kravinoff eventually set on a quest to capture the most elusive prey there is - Spider-Man.
	Spider-Man (Vol. 1) #47 (June 1994)	Vladimir "Vlad" Kravinoff, the son of the original Kraven, is trained by his father's servant and his father to become a hunter akin to his father. Taking the name Grim Hunter Kravinoff sought to hunt both Spider-man and the webslingers foes.
	Spectacular Spider-Man #243 (February 1997)	Alyosha Kravinoff continued his father's legacy after his death.
Jackal	Amazing Spider-Man #129 (February 1974)	Dr. Miles Warren is an Empire State University biology professor who becomes infatuated with Peter Parker's girlfriend, Gwen Stacy. After she dies during a battle between Spider-Man and the Green Goblin, Warren becomes a demented geneticist and clones both Gwen Stacy and Peter Parker. He gains enhanced strength and agility by combining the genetic material of an actual jackal with his own. His genetic tampering later results in the Clone Saga.
Lizard	Amazing Spider-Man #6 (November 1963)	When he lost his arm during a war, Dr. Curt Connors felt like he lost a half of himself. Obsessed with regaining his lost limb, Connors creates a serum from reptilian DNA, in hopes of gaining reptile-like regeneration abilities. He regains his arm, but at a price: he becomes a humanoid lizard, with a savage personality.
Morbius	Amazing Spider-man #101 (October 1971)	Michael Morbius, a Nobel Prize-winning biochemist, attempts to cure himself of a rare blood disease with an experimental treatment involving vampire bats and electroshock therapy. He instead becomes afflicted with a far worse condition that mimics the powers and bloodthirst of vampirism. Morbius now has to digest blood in order to survive and a strong aversion to light. He gains the ability to fly, as well as superhuman strength and healing abilities.
Morlun	Amazing Spider-Man vol. 2. #30 (June 2001)	Morlun is from a race called the Ancients, that feed on "totem" people like Spider-Man. While Spider-Man is learning the true intentions of totemistic hunters from his new friend Ezekiel, Morlun readies for his next hunt: Spider-Man. His original hunt was for Ezekiel who also had Spider powers like Peter.
Mysterio
	Amazing Spider-Man #13 (June 1964)	A disgraced stunt man and special effects artist named Quentin Beck dons an extravagant and theatrical costume as Mysterio and seeks to discredit and frame Spider-Man.
	Amazing Spider-Man #141 (February 1975)	After Beck's death, Daniel Berkhart adopts the identity for a brief time.
	Spider-Man/Black Cat: The Evil that Men Do #1 (August 2002)	Teleporting mutant Francis Klum also briefly becomes Mysterio, before Beck returns from the dead.
Rhino	Amazing Spider-Man #41 (October 1966)	Aleksei Sytsevich is a poor immigrant from Russia who participates in an experiment that bonded a super-strong polymer to his skin and gave him enhanced strength, speed, and stamina.
Sandman	Amazing Spider-Man #4 (September 1963)	While on the run from the law, the escaped convict Flint Marko finds himself on a remote beach during a nuclear weapon testing. His cells are spliced with sand molecules by the radiation, and his body becomes a mass of a sand-like substance.
Scorpion	Amazing Spider-Man #20 (January 1965)	Private investigator Mac Gargan was paid by J. Jonah Jameson to undergo an experimental animal mutation therapy, imbuing him with super-strength, speed, and endurance at the cost of his sanity. Donning a scorpion-based costume, he set out to defeat Spider-Man numerous times and take revenge on Jameson for taking away his humanity.
Shocker	Amazing Spider-Man #46 (March 1967)	A burglar gifted with a head for engineering, Herman Schultz develops a pair of gauntlets capable of throwing incredibly powerful vibrational blasts. He wears a gold and brown quilted costume to protect himself from the vibrations of his gauntlets.
Terrible Tinkerer	Amazing Spider-Man #2 (May 1963)	Originally thought to be an Alien from Amazing Spider-Man #2, the Tinkerer turned out to really be a brilliant man named Phineas Mason who is at the top his game in creating mechanical devices, mostly for super villains
Tombstone	Web of Spider-Man #36 (March 1988)	Lonnie Thompson Lincoln is an African American albino who became a superhuman hitman and mob enforcer known as Tombstone.
Venom
	Amazing Spider-Man #299 (April 1988)	When Spider-Man rid himself of the alien symbiote costume he acquired during the Secret Wars, it bonds with reporter Eddie Brock, who hates Spider-Man for causing him to lose his job and reputation. The symbiote, known as Venom gives Brock all of Spider-Man's powers, protection from his Spider-Sense and the knowledge of Parker's secret identity. Brock would gain a new symbiote and face-off against Mac Gargan as Anti-Venom.
	Marvel Knights: Spider-Man #7 (December 2004)	When Brock decides to turn his life around, the symbiote is sold at auction to Angelo Fortunato. Fortunato uses the Venom identity only briefly before the symbiote abandons him, causing his death.
	Marvel Knights: Spider-Man #9 (February 2005)	After leaving Fortunato, the symbiote attaches itself to Mac Gargan, the supervillain formerly known as the Scorpion.
Vulture
	Amazing Spider-Man #2 (May 1963)	The elderly Adrian Toomes turned to a life of crime after his business partner cheated him. With a self-invented anti-gravity pack, wings for faster flying and a birdlike costume, he became the high-flying, lowdown Vulture.
	Amazing Spider-Man #48 (May 1967)	"Blackie" Drago is a prison cellmate of Toomes's who tricks Toomes and steals the Vulture harness and costume. He uses the suit to make money through air piracy.

Foes of lesser renown

Villain	First appearance	Description
Answer	Lethal Foes Of Spider-Man #4 (July 1984)	Originally, Aaron Nicholson was a very loyal hitman of the Kingpin known as the Answer, but later became an unconscious being of energy.
Armada	Sensational Spider-Man (1988)	Armada is a technology using mercenary hired by Mysterio.
Basilisk	Marvel Team-Up vol. 1, #16 (December 1973)	Basil Elks is a petty thief who breaks into a museum to steal what he believes is an ordinary emerald - but is in fact a Kree artifact called the Alpha Stone. Elks gains multiple superpowers, when the stone shatters, by one of the museums security guards. Basilisk realizes that the Alpha Stone has a twin - the Omega Stone - which he becomes determined to find so as to increase his powers. Basilisk into conflict with Captain Marvel (who is seeking the Stones), Spider-Man, Mr. Fantastic and finally the Mole Man in his underground lair.
Big Man ¤Frederick Foswell ¤Janice Foswell	Amazing Spider-Man #10 (March 1964) Marvel Team-Up #39 (November 1975)	Frederick Foswell was a small and timid reporter working for the Daily Bugle who aspired to be a crime boss. Taking on the identity of the Big Man, Foswell and his Enforcers attempted to take over the New York underworld. The daughter of the original Big Man, Janice Foswell sought to follow in the footsteps of her father and gain control of the New York underworld.
Big Wheel	Amazing Spider-Man #182 (July 1978)	Jackson Weele is a businessman who has embezzled from his company who gets Tinkerer to create a large metal wheel that can climb up buildings, complete with guns and waldo-arms. With this new vehicle, Weele is transformed into Big Wheel, the supervillain.
Black Tarantula	Amazing Spider-Man #419 (January 1997)	Carlos LaMuerto is the most recent in a family line of superpowered vigilante martial artists, all posing as a single immortal figure.
Black Fox	Amazing Spider-Man #255 (August 1984)	Black Fox is a jewel thief with a long international career. In his sixties, he yearns to pull off one last big heist so that he can retire for good to the French Riviera
Boomerang	Tales To Astonish #81 (July 1966)	Fred Myers has no superhuman powers, but he has the strength, agility and endurance of a professional athlete from his days as a baseball player. He can throw projectiles with nearly unerring accuracy, and his aim is nearly the peak of what a non-superpowered human can accomplish. Boomerang's most dangerous assets are, naturally, his arsenal of specialized boomerangs. He has modified and improved on them over the years, but the most common ones are exploding boomerangs (with enough explosive power to destroy an automobile), razor-bladed boomerangs, and boomerangs that release large doses of tear gas to disable a target.
Calypso	Amazing Spider-Man #209 (October 1980)	Calypso Ezili, is a psychopathic voodoo woman who was associated with Sergei Kravinoff, aka Kraven the Hunter.
Carrion ¤Miles Warren clone ¤Malcolm McBride ¤Dr. William Allen	Spectacular Spider-Man #25 (December 1978) Spectacular Spider-Man #149 (April 1989) Spider-Man: Dead Man's Hand (1997)	The first Carrion was originally an extremely decayed and super-powered clone of Dr. Miles Warren. The second Carrion was a college student named Malcolm McBride who had discovered a genetic virus which mutated him into Carrion, who had all the powers and memories of the original Carrion. While examining the corpse of the Miles Warren, Dr. William Allen was infected with an extremely powerful version of the Carrion virus. Using its power to manipulate the minds of others, Carrion III went on a killing-spree in New York City. It was only by using the Jackals old scientific notes that Spider-Man managed to cure Dr. Allen of the Carrion plague.
Chance	Web of Spider-Man #15 (June 1986)	Nicholas Powell was looking for more thrill in his life. He decides to become a mercenary criminal-for-hire, incorporating his love of gambling into his work. Anyone who hires him would, instead of directly paying, bet his fee against him actually completing the mission.
Coldheart	Spider-Man #49 (1994)	Kateri Deseronto was once a government agent with the codename Coldheart. She has the a bulletproof costume and with two swords, one to paralyze and the other to freeze objects. She is proficient in martial arts and sword fighting. After her son's death during a battle between the Hobgoblin and Spider-Man, she was deemed mentally unfit for field duty. Her clearance was revoked and she was forcibly retired. She later confronts both Spider-Man and Hobgoblin, in revenge, after stealing her costume back. Coldheart is arrested and imprisoned in the Raft. Coldheart is apparently one of the many villains that escaped from the Raft. Hiding in Stamford with some other escaped convicts, she was eventually tracked down by the New Warriors. During the battle, Nitro used his powers to explode the entire neighborhood, causing both the death of hundreds of people, the New Warriors, and presumably Coldheart as well.
Cyclone	The Amazing Spider-Man #143 (April 1975)	André Gerard, a French engineer working for NATO, Gerard had a falling out with his former employees, related to political decisions over implementing his research, based on the development of a weapon that generates high velocity tornado-like winds. Cyclone took his invention and used it for his own criminal ends, developing his costume and other weapons
Delilah	Amazing Spider-Man #414 (August, 1996)	The Rose's confidante as well as his chief enforcer, Delilah helped battle to maintain control of part of the New York crime scene against the threat of the Black Tarantula. She had a role in the rebirth of two of Spider-Man's old foes during the Rose's efforts to gain extra muscle: she was the one who threw the switch of the electric chair which gave Electro his powers back, and helped set up the theft of Doctor Octopus' corpse for re-animation from the Hand.
Demogoblin	Web of Spider-Man #86 (March 1992)	The third Hobgoblin, Jason Macendale, wanting power, attempted to sell his soul to the demon N'astirh during the Inferno Crisis. An amused N'astirh declined Macendale's soul and instead grafted a demon to Macendale, "without a catch". Unfortunately for Macendale, the fusion of himself and the demon gave him a hideous appearance and drove him insane. After months of fighting for control of Macendale's body, the demon physically tore himself from Macendale and, christening itself the Demogoblin, set off to purge the world of "sinners".
Doppelganger	Infinity War #1 (June 1992)	A magically created clone of Spider-Man, the Doppelganger was created by the Magus to kill Spider-Man.
Finisher	Amazing Spider-Man Annual #5	An assassin employed by the communist Red Skull who killed Spider-Man's parents. Spider-Man kills Finisher in self defense by turning his own missile against him.
Richard Fisk	Amazing Spider-Man #83	Richard Fisk, the son of crime lord Wilson Fisk, is an anti-hero who has adopted several identities over the years, most notably The Rose. Although his goals are noble ones, the methods he uses cause more harm than good.
Foreigner	Web of Spider-Man #15 (June 1986)	The Foreigner is a mercenary and assassin. Although he has no superhuman abilities, he has trained his body to be in absolute peak physical condition.
Vincente "Don" Fortunato	Spider-Man #70 (May 1996)	A mob boss affiliated with the Maggia and HYDRA, who attempts to fill the vacuum of power in the absence of the Kingpin
Fusion (Hubert and Pinky Fusser)	Amazing Spider-Man (Vol. 1) #208	Hubert and Pinky Fusser are twins both born with dwarfism. One becomes a nuclear scientist, and one becomes janitor at the same privately-owned research corporation where his brother works. When an accident strikes Hubert, his brother rushes to assist. The resulting radiation causes them to become one, a Fusion - a twin-headed radioactive being which contains both of their personalities. The brothers have Superhuman strength, and they can glow and emit radiation.Fusion profile (spiderfan.org)
Fusion (Mr. Markley)	Peter Parker: Spider-Man (Vol. 2) #30	Mr. Markley is a millionaire who can get anything he wants. Markley can persuade people to do what he wants, to see what he wants, and to hear what he wants, controlling people's perceptions. After his son, Francis, dies as a result of trying to imitate Spider-Man, he takes revenge on Spider-Man as Fusion. He attacks and brutally beats Spider-Man by morphing his body parts into those of various heroes. Capturing and brutally torturing Spider-Man in an abandoned warehouse, Fusion is defeated when Spider-Man, realizing the nature of Fusion's powers, manages to pummel him into submission. When he next appears, Fusion, having teamed-up with Doctor Octopus, through a bizarre plot of dismembering and mind-controlling people, manages to get a device which allows him to track Spider-Man. Soon after gaining the device, Fusion is beaten horribly by the traitorous Doctor Octopus and is left for dead, but yet he survives.Fusion profile (spiderfan.org)
Freak	Amazing Spider-Man #552 (March 2008)	A drug addict named "Freak" is chased down by Spider-Man after he attempted to steal from the poor at the soup kitchen Spider-Man's Aunt May works at. He stumbles into a laboratory owned by Curt Connors and injects hiself with animal gene fluids, thinking they were crystal meth. Freak then began to form a chrysalis around his body, emerging as a skinless monster. He blames Spider-man and wants revenge.
Grizzly	Amazing Spider-Man #139 (December 1974)	Markham is a professional wrestler who competed using the nom de guerre of the Grizzly. His violent actions brought him to the attention of J. Jonah Jameson whose article got Maxwell expelled from wrestling. Ten years later, he met with the Jackal who gave him a grizzly bear suit and an exoskeleton harness that amplified his strength and durability. He used this harness to attack the Daily Bugle in an attempt on revenge against Jameson for ruining his wrestling career.
Grey Goblin	Amazing Spider-Man #509	Before her death, Gwen Stacy and Norman Osborn had an affair and Gwen became pregnant with twins: Gabriel and Sarah. Gabriel, like his sister, were born with the goblin formula in their system. Due to this, they both age much faster than a normal human; appearing as adults despite being around 9 years old. After a second dose of Goblin formula, Gabriel took the mantle of Grey Goblin and became very much insane.
Jonas Harrow	Amazing Spider-Man #114 (October 1972)	Jonas Harrow was disgraced as a surgeon and expelled from the medical profession for unorthodox experiments. Jonas Harrow is a genius surgeon, geneticist, cyberneticist and machinesmith who has help to create Hammerhead and enhanced many other supervillains.
Hitman	Spectacular Spider-Man #4 (March 1977)	Burt Kenyon was a costumed mercenary assassin. He was hired by the Maggia as their version of the Punisher. The Vulture had rejected the Maggia's offer before they hired the Hitman, so the Hitman was sent to humiliate the Vulture by killing Spider-Man before the Vulture could.
Human Fly	Amazing Spider-Man Annual #10 (1976)	Richard Deacon was born in Newark, New Jersey. He was a small-time criminal who was shot by the police and left for dead after his unsuccessful kidnapping attempt, which was foiled by Spider-Man. Stumbling into the laboratory of Dr. Harlan Stillwell (whose brother Farley Stillwell created the Scorpion for J. Jonah Jameson), Deacon coerced the scientist into saving his life. Overhearing an offer Jameson made with Stillwell to fund the creation of a new super hero, Deacon insisted he be the subject of the experiment. Stillwell imprinted the genetic coding of a common fly onto Deacon, empowering him and healing him of his bullet wounds. Deacon killed Harlan Stillwell and used his newfound powers to further his criminal ambitions. He first used Jameson as bait to get revenge on Spider-Man, but due to his inexperience he was no match for the web-slinger and he was defeated.
Hypertron 1.0	Web of Spider-Man #83 (December 1991)
Hypno-Hustler	Spectacular Spider-Man #24	Created by Bill Mantlo and Frank Springer, Hypno-Hustler can perform hypnosis with the aid of his guitar, and when teamed with his backup band, The Mercy Killers, can perform mass hypnosis. His boots can emit knockout gas on demand, and have retractable knives in the soles. The Hypno-Hustler also appeared in Spider-Man: Reign, a limited series set in the future, at the end of Spider-Man's career.
Jack O'Lantern	Machine Man #19 (February 1981)	Jason Philip Macendale, known as the original Jack O'Lantern, has no super powers but wares a flaming pumpkin mask and hurls explosive grenades while flying on a disc glider or hopping about on a "pogo platform". He later became the second Hobgoblin.
Kaine	Web Of Spider-Man #119 (December 1994)	Kaine was the first clone of Peter Parker created by Professor Miles Warren who also doubles as the Jackal with only one genetic flaw: He is slowly degenerating due to clone degeneration.
Kangaroo ¤Brian Hibbs ¤Frank Oliver	Amazing Spider-Man #81 (February 1970) Spectacular Spider-Man #242	Frank Oliver was the first Kangaroo but only had two overall appearances in Amazing Spider-Man #81 & 126. In #126 showed the Kangaroo off with his "powered-up" powers courtesy of Dr. Jonas Harrow, the man also responsible for Hammerhead's hard head. Unfortunately, the powers, not to mention radiation poisoning, got the best of Frank and it killed him. A second Kangaroo, Brian Hibbs, jumped onto the scenes in Spectacular Spider-Man #242 with a very brief appearance. Brian Hibbs showed up again as a member of the Legion of Losers along with teammates Grizzly, Gibbon, & The Spot.
Lightmaster	Peter Parker, the Spectacular Spider-Man #3 (February 1977)	Edward Lansky was a physics professor and vice-chancellor of Empire State University who turned to crime and became a criminal mastermind as a way to prevent budget cuts for higher education that would have negatively affected the university. Lansky created a unique special body suit with a padded inner lining, a power armor suit which utilized "gravity-pump circuitry" to allow him to manipulate photons for a variety of effects.
Living Brain	The Amazing Spider-Man #8	The Living Brain was created by the International Computing Machines Corporation and billed as the most intelligent computer and robot in existence, capable of solving virtually any question asked of it.
Lobo Brothers	Spectacular Spider-Man #143 (October 1988)	Carlos and Eduardo Lobo grew up in poverty on the streets of Puebla de Zaragoza, Mexico, surviving by stealing and scavenging for food. As a teenager, Eduardo had fallen in love with a girl name Esmelda Valdez, the daughter of a wealthy ranch owner. The two had a romantic relationship until it was discovered by Esmelda's brother Ramon Valdez. One full moon night, Ramone and his men ambushed the two lovers and tried to drive Eduardo away by using whips on him. Pain and rage from this whipping triggered a mutant change in Eduardo's body. Carlos also discovered he was a mutant werewolf and the brothers turned to crime, using their powers to unite all the mobs of South Texas into Los Hermanos De La Luna. The Lobos were so successful that they not only gained a mansion in a Dallas suburb but drew the attention of the Arranger, the Kingpin's lieutenant. The Arranger used the Persuader to brainwash the Punisher into attempting an assassination of the Lobo Brothers. The plan failed thanks to Spider-Man's interference and the iron will of the Punisher, who ended up killing the Persuader instead. The Lobo Brothers knew who was responsible for the attempt and they vowed revenge.
Looter	Amazing Spider-Man #36 (May 1966)	Norton G. Fester was always a poor scientist, and was considered a crackpot by his colleagues. One day, however, he found an unusual meteor that crashed into the Earth. Excited by his discovery, Fester searched for funding into a project, but investors went for more commercial ventures. Fester decided to continue without funding, and while chiseling the meteor, he struck a pocket of gas. Immersed in the strange compound, he discovered that he now had super-strength and agility thanks to the meteor's powers. Fester decided to devote his time and new powers to crime from then on. Calling himself the Looter, he struck banks and offices everywhere
Jake Martino	Amazing Spider-Man #537 (February 2007)	Jake Martino is a small-time hitman hired by the Kingpin to kill Aunt May, though he only succeeds in shooting and wounding her. Spider-Man resolves to straight-out murder Martino after discovering he was the shooter, but he is shot by another Kingpin assailant before Martino is able to give out the identity of his boss.
Menace	Amazing Spider-Man #549 (February 2008)	Menace's back-story, including his real name, remains largely unknown. He bears a strong resemblance to the Green Goblin/Hobgoblin villains and uses the same style of Goblin glider. Peter suspected that Harry Osborn is Menace but had Lily Hollister his latest girlfriend verify he was not gone during the time Peter fought Menace. The only thing known is that he's been hunted down by Jackpot since his escape from robbing a bank truck. During her search, she meets Spider-Man and reluctantly takes his help. Menace then attacks a council meeting and kidnaps a council woman, and Spider-Man and Jackpot attack him. Unfortunately, Menace's glider slams into the rescued council woman, and Menace escapes the crime scene but not before accusing Spider-Man of being responsible for the woman's death. Recent developments have revealed that Menace uses Osborn's Goblin technology (Osborn recognized it) and he appears to be supporting the Hollister campaign... by threatening Bill Hollister.
Mindworm	Amazing Spider-Man #138	Mindworm was a superhuman mutant with limited telephatic powers. He had an over sized cranium and was naturally extremely intelligent. Eventually, Mindworm attempted to reform but his problems were too difficult for him to control and he allowed himself to be killed by common street thugs to end his great suffering.
Mirage	Amazing Spider-Man #156 (May 1976)	Desmond Charne is a former holography technician who wanted to be a supervillain. To that end, he uses holograph technology which could make him invisible or create 3-D illusions.
Miss Arrow	Friendly Neighborhood Spider-Man #4 (January 2006)	A being composed of pirate spiders first seen in The Other, disguising herself as a human woman, she met Flash Thompson and developed a fixation on him.
Mister Negative	Amazing Spider-Man #546 (January 2008)	Martin Li is a seemingly good willed philanthropist who runs a soup kitchen in Chinatown, the F.E.A.S.T. Project (Food, Emergency Aid, Shelter and Training). Neither Peter nor May are aware of Li's dual identity as a Chinatown crime boss under the name Mister Negative.[4]
Molten Man	Amazing Spider-Man #28 (September 1965)	Mark Raxton was born in New York City. He was a scientist who could not wait to use his skills to become rich, and once worked at Osborn Industries, Inc., as the laboratory assistant to Dr. Spencer Smythe, creator of the Spider-Slayers. Raxton and Smythe developed an experimental new liquid metallic alloy for the Spider-Slayers from a radioactive meteor, but Raxton attempted to steal it and sell it for his own profit. In the ensuing fight with Smythe in the laboratory, Raxton spilled the liquid alloy all over himself, his skin absorbing it and turning golden.
Overdrive	Spider-Man Swing Shift (Free Comic Book Day, 2007)	A Spider-Man fanboy who uses a souped-up car including an electric hood and flaming exhaust.
Polestar	Amazing Spider-Man(vol. 1) #409 (March, 1996)	A pair of mercenaries who used a costume and gauntlets gave him significant control over various magnetic properties.
Puma	Amazing Spider-Man #256 (September 1984)	Thomas Fireheart is the latest in this line of men, used in mystic ceremonies and selective breeding to create a perfect warrior. With the ability to turn into a powerful humanoid mountain lion werecat. He was operating as a mercenary and had been hired by The Rose to kill Spider-Man, but was thwarted by the Black Cat.
Queen	Spectacular Spiderman vol.3 #15 (December 2004)	Adriana Soria is the first female marine in combat during World War II. Adriana and a number of other soldiers are exposed to radiation at Bikini Atol in an attempt to create more super-soldiers. All but Adriana die during this experiment. The mental strain of the experiment unhinges Adriana's mind and she is placed in a military asylum and forgotten. Adriana is a latent mutant who's radiated genetic structure made her into an insect human hybrid, who appears human. Queen surfaces in New York with the ability to control anyone with "insect genes" including those with retrograde DNA pieces. She is able to mutate the DNA in Spider-Man resulting in his becoming a monstrous spider creature before reverting mostly to his original form (Spider-Man gains the ability to generate organic webs). It was Queen's hope that this monstous spider would give birth to a child for her. Queen is seemingly killed by an explosion when Spider-man defeated her though her body was never found.
Ringer	The Defenders #51 (September 1977)	Career criminal Anthony Davis hired the Tinkerer to build him a battlesuit. Upon testing the suit by himself, the Beetle broke into his workshop and the two battled, resulting in Davis becoming the Beetle's prisoner. The Beetle wanted Davis to wear the suit so they could fight Spider-Man together, and convinced Davis to do so because of the deadly explosive weapons built inside the suit.
Scream	Venom: Lethal Protector #4 (1993)	Scream was one of the five Life Foundation Symbiotes that were forcefully spawned from the Venom symbiote. She was their unofficial leader.
Scorcher	Untold Tales of Spider-Man vol. 1, #1 (September 1995)	Steven Hudak was a research chemist who was wrongfully accused of embezzlement by his employer. Swearing revenge, he created an armored suit containing flame-throwing equipment and taking the name "The Scorcher" he attacked his former place of employment.
Scorpia	Spider-Man: The Power of Terror #2 (February 1995)	Elaine Colls is a mental patient at Bellevue Hospital in Hell's Kitchen. She is chosen by Silvermane to become the new Scorpion after the retirement of the original; however, she opted to call herself Scorpia.
Screwball	Amazing Spider-Man #559	Screwball's spectacular stunts and heists are all done for publicity and fame. She uses live streaming to get her videos online.
Sentry	Peter Parker: Spider-Man (Vol. 2) #4 (April, 1999)	A former S.H.I.E.L.D. agent operating as Sentry, Steward Ward is as a double agent for Z'Nox aliens, who use Ward to aid in an invasion of Earth. Years later, as Z'Nox aliens found themselves on Earth during a brief period when it was designated an intergalatic prison, Ward is infected by Z'Nox life-form, mutating him into a half-human/half-alien being. Ranger subsequently sacrificed himself to destroy Ward.
Shadrac	Amazing Spider-Man #2 vol. 2	Gregory Herd wore a cybernetically enhanced costume that allowed him to control or "override" any other electronic device, who worked as a mercenary for hire.
Shathra	Amazing Spiderman vol.2 #46	Shathra is, much as Spider-Man is rumored to be, a totem of the spider wasp. As spider wasps kill spiders, she escaped the astral world where she lived to find Spider-Man.
Shriek	Spider-Man Unlimited #1 (May 1993)	Shriek is a dangerous and criminally insane villainess with the ability to manipulate sound in a number of elaborate ways. She once allied herself with Carnage and several other supervillains who went about New York on a killing spree. Shriek's origins and real name are uncertain. She was named Sandra Deel in her earliest appearances, but named Frances Louise Barrison in later appearances.
Silvermane	Amazing Spiderman #73 (June 1973)	Silvio Manfredi, nicknamed "Silvermane" for his near-white hair, is a professional criminal originally from Sicily who started his criminal career in an organized crime group called the Maggia. Climbing through the ranks and becoming head of the crime family, he eventually formed an alliance with HYDRA, a worldwide organization determined to take over the world.
Sin-Eater	Spectacular Spider-Man #107 (October 1985)	Well known for his murder of Captain Jean DeWolff, Stanley Carter was injected with drugs while with S.H.I.E.L.D. and had his strength & endurance increased.
Spencer Smythe	Amazing Spider-Man #25 (June 1965)	A robotic and arachnid expert convinced by Jameson's editorials that Spider-Man was a menace. Smyth created multiple Spider-Slayer to catch and destroy Spider-Man.
Alistair Smythe	Amazing Spider-Man Annual #19 (1985)	The son of Spencer Smythe, the creator of the Spider-Slayers; after his father died of radiation poisoning, Alistair followed in his footsteps, trying to destroy Spider-Man with robots. Crippled after his first attempt at killing Spider-Man, Alistair regained mobility, as well as superpowers after a combination of self-inflicted mutations and cybernetic implants.
Speed Demon	Avengers #70 (vol. 1, November 1969)	James Sanders first appears under the codename Whizzer, as a member of the Squadron Sinister. Several years after the Squadron Sinister disbands, James Sanders decides to return to crime in a new costume as the Speed Demon and battles Spider-Man.
Spidercide	Spectacular Spider-Man #222 (1995)	During the Clone Saga, in addition to Ben Reilly and Kaine, a third significant clone of Spider-Man was introduced: Spidercide. He died during a battle with Spider-Man, Ben, and Kaine. Scrier recovered his remains and reanimated him, granting him the ability to turn into other materials and shapes in the process. He later mortally wounded Kaine by impaling him. He ultimately betrayed the Jackal in the end, sending a copy of all of the Jackal's data to Scrier. The Jackal found out and tried to kill him, and Spidercide was once again incapacitated when he fell off the top of the Daily Bugle building. His body was taken away by police and placed in a state of suspended animation to keep him from returning again. Unlike most comic book characters who are put into suspended animation only to later return, Spidercide was never seen again.Bio at Spiderfan.orgThe Clone Saga TimelineSpidercide on the Marvel Universe Character Bio WikiSpidercide profile (marvunapp.com)
Spot	Spectacular Spider-Man #48 (January 1985)	Jonathon Ohnn can enter himself through holes, or portals to the spot dimension and he can throw them as a weapon from his body.
Squid	Peter Parker: Spider-Man II #16, (2000)	Don Callahan can shift between his human form and his mouthless squid-like form. Squid and his girlfriend Ms. Fortune battled Spider-Man on a rooftop, and several subsequent occasions.
Stegron	Marvel Team-Up #19 (March 1974)	Dr. Vincent Stegron was hired by S.H.I.E.L.D to assist Dr. Curt Connors in studying dinosaur DNA from the Savage Land. Obsessed with the experiments Connors did to create the Lizard, Stegron stole the DNA samples and injected himself with them. He then transformed into a hominid dinosaur and became bent on reclaiming the earth for the dinosaurs.
Mendel Stromm	Amazing Spider-Man #37 (June 1966)	Stromm was Norman Osborn's college professor, and became his partner in OsCorp Industries. His early research was on a chemical that would provide enhanced strength in its test subjects (and would eventually turn Osborn into the Green Goblin). Osborn, wanting the formula for himself, discovered that Stromm had been embezzling funds from OsCorp, and turned Strom over to the police. After several years in prison, Stromm was released and tried to kill Norman Osborn for revenge using evil robots. He was stopped by Spider-Man and seemingly died of a heart attack. Stromm had made plans for his death, however, by arranging to have his brain waves transferred to a robot double. Now calling himself Robot Master, Stromm returned in Spectacular Spider-Man vol. 1, #68 (July 1982). After being defeated and destroyed Stromm returned several times as a cyborg sometimes known as Gaunt.
Stunner	Amazing Spider-Man #397 (January 1995)	Angelina Brancale was the typical outcast in high school. As she grew older, she never expected to amount to anything, and grew increasingly depressed. Working as a secretary, she was chosen by Doctor Octopus to be the guinea pig for his new virtual reality invention. The test was a success, and Angelina mentally created Stunner, the beautiful, thin woman she always wished she was.
Styx and Stone	Amazing Spider-Man #309 (November, 1988)	Gerald Stone was an idealistic scientist who wanted to find a cure for cancer. He conducted an illegal experiment on a homeless person named Jacob Eishorn. The experiment failed and Eishorn became a living cancer, who needed to kill to survive. Now calling himself "Styx", Eishorn enjoyed the killing of innocents. Feeling responsible for Styx, Stone built high-tech weaponry for himself and turned the two of them into a mercenary duo.
Swarm	Champions #14 (July 1977)	As a former Nazi scientist, Fritz Von Meyer hid in South America after World War II. He became very interested in the breeding and keeping of bees and one day discovered a highly radioactive over-sized beehive due to a meteorite bombardment. The bees that inhabited the hive demonstrated great intelligence. Von Meyer tried to manipulate the bees so that he may train them by using a psionic beam. As a result, the bees underwent even a greater mutation. The bees attacked him and consumed his body in which now only the skeleton existed resulting in a living "Swarm".
Tarantula	Amazing Spider-Man #134 (July 1974)	As a revolutionary terrorist and government operative, Anton Miguel Rodriguez is expelled from his small organization and went on to the other repressive side of the government where they created the identity of the Tarantula for him and to serve as his country's counterpart to Captain America.
Tatterdemalion	Werewolf by Night #9 (September 1973)	Arnold Paffenroth was once a wealthy business investor until the Las Vegas mob swindled him out of all of his money. This resulted in him becoming an insane homeless person. At some point, the agency known as "Night Shift," outfitted Paffenroth with a sophisticated costume. Taking the name "Tatterdemalion" (a person dressed in ragged clothing), he snuck up on unsuspecting victims and proceeded to destroy their money, rather than steal it; an odd twist on mugging.
Thousand	Tangled Web of Spider-Man #1	Carl King became the Thousand when he devoured a dead radioactive spider, which resulted in his transformation from a human being into a hive-minded swarm of a thousand spiders. Discovering his power to consume the innards of other human beings and use their skin like a suit after accidentally doing so to his mother, King proceeds to do the same to his father and, wanting to gain mastery of his new abilities, begins to consume and take over the bodies of various people, most of them homeless vagrants and children.
Toro Negro ("Black Bull")	Amazing Scarlet Spider #2 (December 1995)	El Toro Negro is a South American mercenary and antagonist of Spider-Man closely associated with the Great Game. The mercenary has enhanced strength, speed, durability, and agility; as well as a large arsenal of weapons. The character along with his partner Polestar, kill the superhero Nightwatch, and which EL Toro Negro follows by killing Polestar. was last seen as a captive of his sponsor Justin Hammer, who told him that he would remove Torres' weaknesses — starting with his mind. Hammer then proceeded to forcibly lobotomize the immobilized Torres.
Tracer	Friendly Neighborhood Spider-Man #1 (October 2005)	Tracer claims to be a "machine god" that the artificial intelligences of other machines created to worship, alleging that he becomes stronger over time since the more machines worship him the longer he operates.
Seward Trainer	Peter Parker: Spiderman #52	Seward was the Jackal's trusty assistant and the Jackal couldn't have done all of his cloning without him.
White Rabbit	Marvel Team-Up #131 (July, 1983)	Lorina Dodson, a criminal robbing various fast food joints, most notably "Kwikkee Burgers," armed with Giant Heavily Armed Robotic Rabbit; Genetically Altered Killer Bunny Rabbits; an Umbrella that fires explosive and razor tipped carrots; a pair of rocket boots.
Will o' the Wisp	Amazing Spider-Man #167 (April 1977)	Jackson Arvad, an employee at Roxxon Oil, worked in the division dedicated to electromagnetic research. Unable to save himself from a laboratory accident that made him able to control the level of attraction between his body's molecules.
Wraith	Marvel Team-Up #48 (August 1976)	Brian DeWolff was a former patrolman for the New York Police Department, who was shot by criminals and rescued by his father, using experimental technologies to restore Brian's health. This process gave Brian psionic abilities, including the ability to read minds, induce illusions in the minds of others, project psionic force bolts and control the mind of another person (but he can only control one mind at a time), but left him with no mind of his own and succeptable to the mental domination of others.

Group villains

Villain	First appearance	Description
Enforcers	Amazing Spider-Man #10 (March 1964)	The Enforcers came together to combine their forces and become a very powerful band of criminals that has been very much in demand by many criminal leaders over the years. Its members are self trained as none have superhuman powers.
Jury	Amazing Spider-Man #383	The group first appearsin Venom: Lethal Protector and consists of Sentry, Ramshot, Screech, Bomblast, Firearm, Wysper, and U.S. Agent.
Sinister Six	Amazing Spiderman Annual #1 (1964)	The Sinister Six is formed by Doc Ock, one of Spider-Man's major enemies. He thought if Spider-Man's six greatest villains join together they can defeat the web-slinger, so he hunts down 5 others: Vulture, Electro, Sandman, Mysterio, and Kraven the Hunter. He organizes a plan for each to attack Spider-Man one by one until Spider-Man is defeated. They kidnapp Betty Brant and Aunt May to make Spider-Man fight. Spider-Man defeats the six villains one by one until they are all defeated. The group reforms many times with varying membership and various numbers including Sinister Seven and Sinister Twelve, though the Vulture has always been present.
Sinister Syndicate	Amazing Spider-Man #280	Patterned after the conglomeration of Spider-Man's deadliest foes who call themselves the Sinister Six, the Sinister Syndicate originally is formed by the super-villain Abe Jenkins, aka "The Beetle".

Made-For-TV villains

These villains don't appear in the comics. They were created for the various cartoon series. Among them villains are:

Spider-Man (1967)

Main article: Spider-Man (1967 TV series)

• Baron Von Rantenraven: He invaded New York with WWII Airplanes.
• Bolton: Bolton is a Martian warrior who can throw thunderbolts. He worked together with Boomer.
• Boomer: Boomer is a criminal who uses bombs. He worked together with Bolton.
• Charles Cameo: Charles Cameo is a former actor who uses disguises to commit crimes. He once impersonated the Prime Minister of Rutania.
• Clive: Clive is a movie producer who plans revenge on the movie critics and audiences by creating Blotto.
• Desperado: He is a cowboy on a robotic horse.
• Dr. Atlantean: Dr. Atlantean is a scientist from Atlantis who brought Manhattan underwater. He is a redrawn version of the Radiation Specialist.
• Dr. Cool: He is a diamond thief who was robbing diamonds while hiding out in a warehouse with a freezer in it.
• Dr. Magneto: Dr. Matto Magneto is a scientist armed with a gun that can magnetize and de-magnetize objects. He planned revenge upon the world for ridiculing his theories.
• Dr. Manta: He's actually a Rocket Robin Hood villain. He used giant, mechanical beetles to enslave an island's inhabitants.
• Dr. Noah Body: A brilliant scientist who has somehow found a way to make himself invisible. In his first appearance, he took revenge on J. Jonah Jameson for ridiculing his theories of invisibility. In the second appearance, he broke Electro, Green Goblin, and Vulture out of jail to take out Spider-Man.
• Dr. Dumpty: Dr. Humperdink Dumpty is a jewel thief who stole the jewels of actress Rachel Welles when he attacked a parade.
• Dr. Vespian: He is a scientist who developed a drinkable invisibility serum that he tested on himself and his dog.
• Dr. Von Schlick: He is an evil scientist who wears a rubber, non-stick costume with petroleum-based bubbles emitted from his fingers. Spider-Man had to use a special webbing to stop him.
• Dr. Zap: Dr. Zap is an electric-powered Chinese scientist who kidnapped Dr. Irving Caldwell in order to learn the secrets of Dr. Caldwell's levitation helmet.
• Fantastic Fakir: He is an Arabian Fakir whose flute can create illusions and control animals.
• Fiddler: Otto is a man who hates rock and roll for it replacing classical music. He used a deadly violin to seek revenge on Cyrus Flintridge.
• Fifth Avenue Phantom: He is quite possibly the most unremarkable villain from the '67 animated series. He appeared in "The Fifth Avenue Phantom" and "The Dark Terrors". He used a device that shrank valuables as well as android women who masqueraded as fashion mannequins. In his second appearance, he used a Shadow-Scope to create Shadow Monsters to commit crimes.
• Harley Clivendon: Harley Clivendon is an Australian who one time hypnotized J. Jonah Jameson with an idol.
• Human Fly Twins: Stan and Lee Patterson are former circus acts who reverted to crime.
• Infinata: He's actually a Rocket Robin Hood villain. Infinata is from the Fifth Dimension. He attempted to steal the Universal Library from a dying scientist who came from the destroyed planet Gorth.
• Kotep the Scarlet Sorcerer: Kotep was an ancient Egyptian sorcerer who was defeated by his opponent and placed in suspended animation until a professor at Peter Parker's school used an incantation to awaken him.
• Master Vine: He is a leader of a race of plant people in an alternate dimension.
• Microman: Professor Pretories is a diabolical scientist who has a light that can shrink him to a small size.
• Miss Trubble: Miss Trubble had a chest that enabled her to summon living statue versions of Greek Mythology characters and creatures.
• Mole Man: A human masquerading as a member of an underground race, he uses the mole-people's technology to rip buildings from their foundation and send them underground. Loosely based on the Fantastic Four's Mole Man.
• Mugs Riley: Mugs Riley is a criminal who escaped from jail and discovered an underground society of Molemen. He used them to commit crimes while disguised as a Moleman.
• Pardo: Pardo is a sorcerer who can turn into a black cat and rob people in a movie theatre.
• Parafino: He is the owner of Parafino's Wax Museum. He one time used wax mannequins of Blackbeard, Jesse James, and the Executioner of Paris to commit crimes.
• Plotter: Plotter is a criminal mastermind who hires Ox and Cowboy to steal a blueprint for a missile.
• Radiation Specialist: The Radiation Specialist took over Manhattan's new and only Nuclear Power Plant and uses a special ray in it to lift Manhattan into the clouds unless the city meets his demands: he is amply paid, granted amnesty from arrest, and permitted to build his own nuclear reactor. He had a radiation gun which gave Spider-Man a disadvantage.
• Scarf: Scarf is a masked villain who uses illusions.
• Skymaster: Skymaster is a criminal that resides in a blimp. He kidnapped the school's football star Roy Robinson so that he can force his father to reveal the invisibility serum's ingredients.
• Super Swami: He is an Oriental-illusionist.

Spider-Man (1981 TV series)

Main article: Spider-Man (1981 TV series)

• Gadgeteer: Gadgeteer whose real first name is Joshua is an evil janitor who takes on this identity to steal Dr. Norton's shrink ray.
• Nephilia: Dr. Bradley Shaw and his assistant Penny plotted to attain Spider-Man's blood into order to duplicate his powers use them for Bradley's own needs. Unfortunately, he ends up becoming Nephilia: a mutant with a man's torso and a spider body from the waist down.
• Professor Gizmo: Professor Gizmo is a master criminal who planned to use Spider-Man to attach an antenna to the large sunken treasure ship, the El Conquistador.
• Sidewinder: Sidewinder is a masked cowboy villain who rides a flying, robot horse. He leads a gang of cowboys who also ride flying, robot horses.
• Stuntman: Jack Riven was the World's Greatest Stuntman until an accident permanently fused him to a mechanical suit of armor a few years ago. He blames Spider-Man for that. Stuntman has two lackey named Larry and Moe who help make up the Triangle of Evil.

Spider-Man and His Amazing Friends (1981)

Main article: Spider-Man and His Amazing Friends

• Arachnoid: Zolton is a chemical scientist who creates a Spider-Serum that will give him Spider-Powers. He impersonates Spider-Man when committing crimes until he mutates into the Arachnoid: a mutant with the torso of a man and a spider's body from the waist down. This plot was somewhat based on Nephilia's.
• Buzz Mason: He is a S.H.I.E.L.D. agent who secretly controlled Lightwave into committing robberies of a device that will enable him to control a satellite called the GUARDSTAR.
• Cyberiad: Nathan Price was Firestar's lover until an accident caused by an attack by AIM caused him to end up as a cyborg called Cyberiad. He attacked the X-Men Mansion and captured its members one-by-one. His design is based on Fatal Five member Tharok.
• Gamesman: The Gamesman plotted to cause havoc in New York by using the arcade games to hypnotize the teenagers there. He unwittingly caused Francis Byte to become Videoman resulting in Gamesman to manipulate him.
• Lightwave: Aurora Dante is Iceman's half-sister who can manipulate and control light. She is an agent of S.H.I.E.L.D. until Buzz Mason controlled her into stealing a device that will allow Buzz to control the GUARDSTAR. Lightwave is based on Aurora and Darkstar.
• Videoman: Electro brought it out of an arcade game to steal components for his Ultra-Transformer, but was defeated by the Spider-Friends. Videoman was released again during a thunderstorm. A teenage video game prodigy named Francis Byte ends up becoming Videoman due to an explosion caused by the Gamesman's plot where Francis learns to become a good superhero. After the Gamesman's defeat, he is now training with the X-Men.

Spider-Man (1994 TV series)

Main article: Spider-Man (1994 TV series)

• Herbert Landon
• Iceberg: He was a frozen crime lord that works for the Kingpin and that Hobbie Brown used to work for before becoming the Prowler.
• Mirium: In this series, she is a Vampire Queen and the mother of Blade.

Spider-Man: The New Animated Series (2003)

Main article: Spider-Man: The New Animated Series

• Dr. Zellner: He developed a drug that would make stupid people intelligent. He tested it on thug twins Jack and Mack and used them to commit crimes.
• The Gaines Twins: Roland and Roxanne Gaines are twins with mind powers who messed with Spider-Man's mind.
• Pterodax: Pterodax is a high-tech mercenary group led by Sergai.
• Shikata: Shikata is a martial arts expert and swordsman who uses a sword and incantation to stay young. She wanted to fight Spider-Man to the finish. After some info from Mary-Jane, Spider-Man destroyed the sword which ended Shikata's life.
• Talon: Cheyenne Tate is a high-tech thief who was a love interest for Harry Osborn. She is somewhat based on Black Cat and Lily Hollister.
• Turbo Jet: As Turbo Jet, Wyler acts like a modern-day Robin Hood with the stealing from the rich and giving to the poor while wearing a high-tech suit. He is said to be based on Rocket Racer.