Erythrose: Difference between revisions

Erythrose^[1]
	; D-Erythrose
	; L-Erythrose
Names
	IUPAC names (2R,3R)-2,3,4-Trihydroxybutanal (D); (2S,3S)-2,3,4-Trihydroxybutanal (L)
Identifiers
CAS Number	583-50-6 (D) ; 533-49-3 (L) ;
3D model (JSmol)	(D): Interactive image; (L): Interactive image;
ChEBI	CHEBI:27904 ;
ChemSpider	84990 (D) ;
ECHA InfoCard	100.008.643
PubChem CID	94176 (D);
CompTox Dashboard (EPA)	DTXSID601318240 ;
	InChI InChI=1S/C4H8O4/c5-1-3(7)4(8)2-6/h1,3-4,6-8H,2H2/t3-,4+/m0/s1 Key: YTBSYETUWUMLBZ-IUYQGCFVSA-N ; InChI=1/C4H8O4/c5-1-3(7)4(8)2-6/h1,3-4,6-8H,2H2/t3-,4+/m0/s1 Key: YTBSYETUWUMLBZ-IUYQGCFVBI;
	SMILES (D): OC[C@@H](O)[C@@H](O)C=O; (L): OC[C@H](O)[C@H](O)C=O;
Properties
Chemical formula	C4H8O4
Molar mass	120.104 g·mol−1
Appearance	Light yellow syrup
Solubility in water	Very soluble
Hazards
NFPA 704 (fire diamond)	1 1 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

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Revision as of 02:03, 17 March 2015

Erythrose is a tetrose carbohydrate with the chemical formula C₄H₈O₄. It has one aldehyde group, and so is part of the aldose family. The natural isomer is D-erythrose.

Erythrose, as glucose, is fuel of cellular energy, can be oxidized to carbon dioxide and water to supports normal cells.^[2]

Erythrose is an anti-cancer agent. In vitro, ~4mM erythrose effectively kills cancer cells for tested cell lines (in vitro), such as: lung, brain,breast,and colorectal cancers, etc. ^[3]

D-Erythrose inhibits tumor growth in mice (in vivo). ^[4]

Erythrose is a 2/3 of Glucose. Diabetics can have blood sugar (mainly glucose)up to 30mM for days. The concentration of erythrose required to kill cancer is much lower than glucose in our body. What Erythrose can do for cancer patients needs further study.

Erythrose was first isolated in 1849 from rhubarb by the French pharmacist Louis Feux Joseph Garot (1798-1869),^[5] and was named as such because of its red hue in the presence of alkali metals (ἐρυθρός, "red").^[6]^[7]

Erythrose 4-phosphate is an intermediate in the pentose phosphate pathway^[8] and the Calvin cycle.^[9]

Erythrulose, an isomer of erythrose, is non-toxic.^[10]

Oxidative bacteria can be made to use erythrose as its sole energy source.^[11]

References

^ Merck Index, 11th Edition, 3637
^ Batt RD, Dickens F, Williamson DH. 1960. Tetrose metabolism 2. The utilization of tetroses and tetritols by rat tissues. Biochem J. 77:281-94.
^ Wang X and Wei Y 2010 “Erythrose kill cancer cell in vitro and inhibit tumor growth in mice (in vivo)” American Association for Cancer Research 101st Conference.
^ LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma ONCOLOGY LETTERS 9: 769-773, 2015
^ Obituary of Garot (1869) Journal de pharmacie et de chimie, 4th series, 9 : 472-473.
^ Garot (1850) "De la matière colorante rouge des rhubarbes exotiques et indigènes et de son application (comme matière colorante) aux arts et à la pharmacie" (On the red coloring material of exotic and indigenous rhubarb and on its application (as a coloring material) in the arts and in pharmacy), Journal de Pharmacie et de Chimie, 3rd series, 17 : 5-19.
^ Wells, David Ames; Cross, Charles Robert; Bliss, George; Trowbridge, John; Nichols, William Ripley; Kneeland, Samuel (1851). Annual of Scientific Discovery. Boston: Gould, Kendall, and Lincoln. p. 211. Retrieved 11 December 2014.
^ Kruger, Nicholas J; von Schaewen, Antje (June 2003). "The oxidative pentose phosphate pathway: structure and organisation". Current Opinion in Plant Biology. 6 (3): 236–246. doi:10.1016/S1369-5266(03)00039-6. Retrieved 11 December 2014.
^ Schwender, Jörg; Goffman, Fernando; Ohlrogge, John B.; Shachar-Hill, Yair (9 December 2004). "Rubisco without the Calvin cycle improves the carbon efficiency of developing green seeds". Nature. 432 (7018): 779–782. doi:10.1038/nature03145. Retrieved 11 December 2014.
'^ National Industrial Chemicals Notification and Assessment Scheme (NICNAS). Erythrulose. Australia February 11, 2008.
^ Hiatt, Howard H; Horecker, B L (13 October 1955). "D-erythrose metabolism in a strain of Alcaligenes faecalis". Journal of Bacteriology. 71 (6): 649–654. Retrieved 11 December 2014.

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[1] Merck Index, 11th Edition, 3637

[2] Batt RD, Dickens F, Williamson DH. 1960. Tetrose metabolism 2. The utilization of tetroses and tetritols by rat tissues. Biochem J. 77:281-94.

[3] Wang X and Wei Y 2010 “Erythrose kill cancer cell in vitro and inhibit tumor growth in mice (in vivo)” American Association for Cancer Research 101st Conference.

[4] LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma ONCOLOGY LETTERS 9: 769-773, 2015

[5] Obituary of Garot (1869) Journal de pharmacie et de chimie, 4th series, 9 : 472-473.

[6] Garot (1850) "De la matière colorante rouge des rhubarbes exotiques et indigènes et de son application (comme matière colorante) aux arts et à la pharmacie" (On the red coloring material of exotic and indigenous rhubarb and on its application (as a coloring material) in the arts and in pharmacy), Journal de Pharmacie et de Chimie, 3rd series, 17 : 5-19.

[7] Wells, David Ames; Cross, Charles Robert; Bliss, George; Trowbridge, John; Nichols, William Ripley; Kneeland, Samuel (1851). Annual of Scientific Discovery. Boston: Gould, Kendall, and Lincoln. p. 211. Retrieved 11 December 2014.

[8] Kruger, Nicholas J; von Schaewen, Antje (June 2003). "The oxidative pentose phosphate pathway: structure and organisation". Current Opinion in Plant Biology. 6 (3): 236–246. doi:10.1016/S1369-5266(03)00039-6. Retrieved 11 December 2014.

[9] Schwender, Jörg; Goffman, Fernando; Ohlrogge, John B.; Shachar-Hill, Yair (9 December 2004). "Rubisco without the Calvin cycle improves the carbon efficiency of developing green seeds". Nature. 432 (7018): 779–782. doi:10.1038/nature03145. Retrieved 11 December 2014.

[10] '^ National Industrial Chemicals Notification and Assessment Scheme (NICNAS). Erythrulose. Australia February 11, 2008.

[11] Hiatt, Howard H; Horecker, B L (13 October 1955). "D-erythrose metabolism in a strain of Alcaligenes faecalis". Journal of Bacteriology. 71 (6): 649–654. Retrieved 11 December 2014.

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@@ Line 61: / Line 61: @@
 '''Erythrose''' is an anti-cancer agent. In vitro, ~4mM erythrose effectively kills cancer cells for tested cell lines (in vitro), such as: lung, brain,breast,and colorectal cancers, etc.  <ref>Wang X and Wei Y 2010 “Erythrose kill cancer cell in vitro and inhibit tumor growth in mice (in vivo)” American Association for Cancer Research 101st Conference.</ref>
-'''D-Erythrose''' inhibits tumor growth in vivo. <ref>LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma  ONCOLOGY LETTERS 9: 769-773, 2015</ref>
+'''D-Erythrose''' inhibits tumor growth in mice (in vivo). <ref>LILI LIU, TAO YI and XIA ZHAO 2015. Antitumor effect of D-erythrose in an abdominal metastatic model of colon carcinoma  ONCOLOGY LETTERS 9: 769-773, 2015</ref>
 '''Erythrose''' is a  2/3 of  '''Glucose'''. Diabetics can have blood sugar (mainly glucose)up to 30mM for days. The concentration of erythrose required to kill cancer is much lower than glucose in our body. What '''Erythrose''' can do for cancer patients needs further study.