User:Qunho/CYP3A4: Difference between revisions
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|+'''Selected inducers, inhibitors and substrates of CYP3A4''' |
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! Inhibitors !! Inducers |
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|<!--substrates--> |
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'''Strong'''<!--inhibitors--> |
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* [[Pharmacologic protease inhibitor|protease inhibitors]] |
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** [[ritonavir]] |
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** [[indinavir]] |
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** [[nelfinavir]] |
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** [[saquinavir]] |
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*some [[Macrolide|macrolide antibiotic]]s |
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** [[clarithromycin]] |
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** [[telithromycin]] |
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* [[chloramphenicol]] ([[antibiotic]]) |
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*some [[azole antifungal]]s |
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**[[ketoconazole]] |
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** [[itraconazole]] |
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**[[posaconazole]] |
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**[[voriconazole]] |
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* [[nefazodone]] ([[antidepressant]]) |
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* [[cobicistat]] |
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'''Moderate'''<!--inhibitors--> |
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*[[amiodarone]] |
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*[[aprepitant]] ([[antiemetic]]) |
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*some [[calcium channel blocker]]s |
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** [[verapamil]] |
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** [[diltiazem]] |
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*some [[Macrolide|macrolide antibiotic]]s |
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** [[erythromycin]] |
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*some [[azole antifungal]]s |
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**[[fluconazole]] |
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**[[miconazole]] |
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* [[bergamottin]] (constituent of [[grapefruit]] juice) |
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* [[cimetidine]] |
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* [[ciprofloxacin]] |
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* cyclosporine |
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* [[Dronedarone|donedarone]] |
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* [[fluvoxamine]] |
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* [[imatinib]] |
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* [[Valerian (herb)|Valerian]] |
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* [[verapamil]] |
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'''Weak'''<!--inhibitors--> |
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* [[buprenorphine]] ([[analgesic]]) |
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* [[cafestol]] (in unfiltered coffee) |
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*[[cilostazol]] |
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*[[fosaprepitant]] |
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*[[gabapentin]] |
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*[[lomitapide]] |
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*[[orphenadrine]] |
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*[[ranitidine]] |
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*[[ranolazine]] |
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*[[tacrolimus]] |
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*[[ticagrelor]] |
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* [[valproic acid]] |
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'''<!--inhibitors of-->Unspecified potency''' |
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* [[cannabidiol]] |
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* [[dithiocarbamate]] (functional group) |
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* [[mifepristone]] ([[abortifacient]]) |
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* [[norfloxacin]] (antibiotic) |
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* some non-nucleoside [[reverse transcriptase inhibitor]]s |
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** [[delavirdine]] |
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* [[gestodene]] ([[hormonal contraceptive]]) |
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* [[mibefradil]] (in [[angina pectoris]]) |
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* [[carambola|star fruit]] |
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* [[milk thistle]] |
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* [[Nicotinamide|niacinamide]] |
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* [[ginkgo biloba]] |
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*[[piperine]] |
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* [[isoniazid]] |
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*[[quercetin]] |
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'''<!--inducers of-->Strong potency''' |
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* [[antiandrogen]]s |
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** [[enzalutamide]] |
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** [[apalutamide]] |
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* [[phenytoin]] |
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'''<!--inducers of-->Unspecified potency''' |
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* [[anticonvulsant]]s, [[mood stabilizers]] |
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** [[carbamazepine]] |
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** [[phenytoin]] ([[anticonvulsant]]) |
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** [[oxcarbazepine]] |
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** [[topiramate]] |
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* [[barbiturates]] |
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** [[phenobarbital]] |
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** [[Butalbital]] |
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* [[St. John's wort]] |
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*some [[bactericidal]]s |
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** [[rifampicin]] |
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** [[rifabutin]] |
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* some non-nucleoside [[reverse transcriptase inhibitor]]s |
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** [[efavirenz]] |
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** [[nevirapine]] |
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*some [[hypoglycemic]]s |
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** [[pioglitazone]] |
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** [[troglitazone]] |
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* [[glucocorticoids]] ([[blood glucose]] increase, [[immunosuppressive]]) |
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* [[modafinil]] ([[stimulant]]) |
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*[[quercetin]] |
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*[[capsaicin]] |
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Revision as of 13:10, 3 January 2019