Jeryl Lynn
In 1963 Jeryl Lynn Hilleman contracted mumps. Her father, Dr. Maurice Hilleman, was at the time involved in efforts to produce a mumps vaccine. He cultured the Mumps virus from her throat, successfully, and in the end a vaccine was produced from this which is now widely used. The mumps vaccine viral strain is named after her.
- Jeryl Lynn strain-based mumps vaccine
The Jeryl Lynn vaccine later turned out to be a combination of two attenuated substrains of Mumps virus. The Jeryl Lynn strain is used today in the production of Mumpsvax, the Mumps vaccine manufactured by Merck.
The Jeryl Lynn strains used in the manufacture of Mumpsvax have been reported to contain two distinguishable viral substrains, JL1 and JL2.[1] Further research showed that the JL1 strain was preferentially selected by propagation in Vero and CEF cell cultures. The JL2 strain was preferentially selected by passage in embryonated chicken eggs.[2]
The Jeryl Lynn strain-based vaccines supplanted the older, killed virus, vaccine by 1978.
See also
- Complete genome of JL1[3]
- Complete genome of JL2[4]
- The Jeryl Lynn Story an animation for children due for vaccination and their parents.
References
- ^ Amexis G,Paul Oeth,Kenneth Abel,Anna Ivshina,Francois Pelloquin,Charles R. Cantor,Andreas Braun,and Konstantin Chumakov (2001). "Quantitative mutant analysis of viral quasispecies by chip-based matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry". Proceedings National Academy Science USA. The National Academy of Sciences. PMID 59774.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Amexis G, Rubin S, Chizhikov V, Pelloquin F, Carbone K, Chumakov K. (2002). "Sequence diversity of Jeryl Lynn strain of mumps virus: quantitative mutant analysis for vaccine quality control". Virology. Elsevier. PMID 12350348.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K. (2002). "Mumps virus (STRAIN JERYL-LYNN) live vaccine major component, complete genome". Virology.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Amexis,G., Rubin,S., Chizhikov,V., Pelloquin,F., Carbone,K., Chumakov,K. (2002). "Mumps virus (STRAIN JERYL-LYNN) live vaccine minor component JL2, complete genome". Virology.
{{cite journal}}: CS1 maint: multiple names: authors list (link)