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This is an old revision of this page, as edited by 45.72.141.216 (talk) at 21:20, 10 May 2017 (→‎Semi-protected edit request on 25 April 2017: +). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Good articleMethamphetamine has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do so. If it no longer meets these criteria, you can reassess it.
Did You Know Article milestones
DateProcessResult
December 9, 2006Featured article candidateNot promoted
December 10, 2006Peer reviewReviewed
December 26, 2008Good article nomineeNot listed
January 27, 2014Good article nomineeListed
Did You Know A fact from this article appeared on Wikipedia's Main Page in the "Did you know?" column on November 3, 2005.
Current status: Good article

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Neurotoxicity update

CC-by-2.5 neurodegeneration image from this ref.[1]

Reviews to add (at some point)...

  1. [2] - includes coverage of human low-dose methamphetamine-induced neurotoxicity
  2. [3] - 2nd human neurotoxicity review

Seppi333 (Insert 2¢) 03:45, 13 July 2015 (UTC); Updated: 13:09, 16 January 2016 (UTC)[reply]

Neuropsychological effects review

Section reflist

References

  1. ^ a b Beardsley PM, Hauser KF (2014). "Glial modulators as potential treatments of psychostimulant abuse". Adv. Pharmacol. 69: 1–69. doi:10.1016/B978-0-12-420118-7.00001-9. PMC 4103010. PMID 24484974.
  2. ^ Yu S, Zhu L, Shen Q, Bai X, Di X (March 2015). "Recent advances in methamphetamine neurotoxicity mechanisms and its molecular pathophysiology". Behav. Neurol. 2015: 103969. doi:10.1155/2015/103969. PMC 4377385. PMID 25861156.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  3. ^ Salamanca SA, Sorrentino EE, Nosanchuk JD, Martinez LR (January 2015). "Impact of methamphetamine on infection and immunity". Front. Neurosci. 8: 445. doi:10.3389/fnins.2014.00445. PMC 4290678. PMID 25628526.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Saha K, Sambo D, Richardson BD, Lin LM, Butler B, Villarroel L, Khoshbouei H (August 2014). "Intracellular methamphetamine prevents the dopamine-induced enhancement of neuronal firing". J. Biol. Chem. 289 (32): 22246–22257. doi:10.1074/jbc.M114.563056. PMID 24962577. The primary target of psychostimulants such as amphetamine and methamphetamine is the dopamine transporter (DAT), the major regulator of extracellular dopamine levels in the brain. However, the behavioral and neurophysiological correlates of methamphetamine and amphetamine administration are unique from one another, thereby suggesting these two compounds impact dopaminergic neurotransmission differentially. ... The intracellular application of methamphetamine, but not amphetamine, prevented the dopamine-induced increase in the spontaneous firing of dopaminergic neurons and the corresponding DAT-mediated inward current. The results reveal a new mechanism for methamphetamine-induced dysregulation of dopaminergic neurons.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Steinkellner T, Freissmuth M, Sitte HH, Montgomery T (2011). "The ugly side of amphetamines: short- and long-term toxicity of 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy'), methamphetamine and D-amphetamine". Biol. Chem. 392 (1–2): 103–15. doi:10.1515/BC.2011.016. PMC 4497800. PMID 21194370. d-AMPH and METH vary considerably in their toxic and addictive effects. Although d-AMPH has a higher affinity for DAT than METH (Howell and Kimmel, 2008), the latter is a more potent and also more perilous stimulant than d-AMPH. This could be as a result of their differing effects on cellular targets such as MAOs, mitochondrial electron transport chain complexes and their interactions with different signal transduction pathways. METH is more lipophilic than d-AMPH. Therefore, it readily enters the cell via diffusion in addition to DAT-dependent uptake. Furthermore, METH has been shown to release more DA and intracellular Ca2+ than d-AMPH at physiologic membrane potentials. These effects can be blocked by DAT inhibitors (Goodwin et al., 2009). This increased DA release perhaps provides an explanation for the enhanced abuse potential and the strong euphoric effects of acute METH exposure in humans. Chronic METH abuse leads to the degeneration of monoaminergic terminals (Davidson et al., 2001; Krasnova and Cadet, 2009) and reduced DAT and DA levels in the striatum of mice, rats and monkeys (Anderson and Itzhak, 2006; Graham et al., 2008; Melega et al., 2008). Similar effects have been reported in people subjected to positron emission tomography (PET) (Volkow et al., 2001). In contrast to MDMA, the metabolism of d-AMPH/METH does not appear to be significant in the manifestation of drug neurotoxicity. However, increases in DA metabolism following d-AMPH/METH-induced DA release have been implicated in the expression of amphetamine neurotoxicity, primarily through the production of oxidative stress (Krasnova and Cadet, 2009).
  6. ^ Matsumoto RR, Nguyen L, Kaushal N, Robson MJ (2014). "Sigma (σ) receptors as potential therapeutic targets to mitigate psychostimulant effects". Adv. Pharmacol. 69: 323–386. doi:10.1016/B978-0-12-420118-7.00009-3. PMID 24484982.
  7. ^ Kaushal N, Matsumoto RR (March 2011). "Role of sigma receptors in methamphetamine-induced neurotoxicity". Curr Neuropharmacol. 9 (1): 54–57. doi:10.2174/157015911795016930. PMC 3137201. PMID 21886562.
  8. ^ Rodvelt KR, Miller DK (September 2010). "Could sigma receptor ligands be a treatment for methamphetamine addiction?". Curr Drug Abuse Rev. 3 (3): 156–162. doi:10.2174/1874473711003030156. PMID 21054260.
  9. ^ Friend DM, Fricks-Gleason AN, Keefe KA (2014). "Is there a role for nitric oxide in methamphetamine-induced dopamine terminal degeneration?". Neurotox Res. 25 (2): 153–60. doi:10.1007/s12640-013-9415-2. PMC 3880644. PMID 23918001.
  10. ^ Cadet JL, Bisagno V (January 2016). "Neuropsychological Consequences of Chronic Drug Use: Relevance to Treatment Approaches". Front. Psychiatry. 6: 189. doi:10.3389/fpsyt.2015.00189. PMC 4713863. PMID 26834649.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

The external link to "Drug Trafficking Aryan Brotherhood Methamphetamine Operation Dismantled, FBI" is dead (https://www.fbi.gov/news/stories/2015/december/drug-trafficking/). I did a search on the site and found a new link, but I can not edit a protected page. So here it is if anyone wants to correct it:

https://www.fbi.gov/news/stories/aryan-brotherhood-methamphetamine-operation-dismantled

104.51.149.199 (talk) 11:36, 8 November 2016 (UTC)[reply]

Thanks. I have updated the link accordingly. (In the future, you can use {{Edit semi-protected}} to call attention to requests such as this to get ensure a quicker response.) -- Ed (Edgar181) 12:38, 8 November 2016 (UTC)[reply]

Therapeutic use of methamphetamine in Canada

There are examples of meth use where the person reports positive changes that outlast the effects of the drug. I suspect that oral use may lead to more of these changes than snorting or smoking it.

Is there room on this site for reports of therapeutic effects? Maybe a new heading on the main methamphetamine page?

People should be informed if there are longlasting effects — Preceding unsigned comment added by Bhellos (talk • contribs) 19:45, 11 November 2016 (UTC)[reply]

Lacking sources that meet WP:MEDRS, this is merely promoting a FRINGE viewpoint. Either produce reliable sources, or this will be removed shortly. John from Idegon (talk) 19:58, 11 November 2016 (UTC)[reply]
I think the editor is attempting to be constructive. Let's not bite the newbies. There is a large learning curve. Anyway, what John from Idegon is trying to get at is that biomedical information requires more stringent sourcing standards (since people's health is at stake). If you can find a scholarly review article or meta-analysis supporting what you're saying we can include this. Sizeofint (talk) 23:15, 11 November 2016 (UTC)[reply]

Lead

The article says " 'Meth' and 'crystal meth' redirect here." But no synonyms are given. Some slang names would we useful. 31.49.105.253 (talk) 01:22, 15 February 2017 (UTC)[reply]

They are in the note in the first sentence. Sizeofint (talk) 04:57, 16 February 2017 (UTC)[reply]
That isn't the first sentence... that is an article hatnote which is fairly commonly skipped (much in the same way readers unconsciously skip-over ads [see, Ad blindness] on a website [see also Inattentional blindness]) unless something tips the user to think they are looking at the wrong article. A hatnote saying a term redirects to this article does not necessarily mean the terms in the hatnote are synonyms for the article topic (for several article, such terms in a hotnote turn out to be explicitly not synonyms), it only means those terms redirect here. IP user above does have a point that common synonyms should be mentioned in case people end up here wondering what a term refers to. — al-Shimoni (talk) 12:23, 21 February 2017 (UTC)[reply]
He was talking about this note. Seppi333 (Insert 2¢) 05:17, 22 February 2017 (UTC)[reply]

Civilian use of Pervitin in WWII Germany

Suggested addition to Section 8 -History, society, and culture. (I'd add it myself but have not mastered footnoting.)

[1]

[Excerpt from a book review entitled] The Very Drugged Nazis by Antony Beevor

Blitzed: Drugs in the Third Reich by Norman Ohler, translated from the German by Shaun Whiteside Houghton Mifflin Harcourt, 292 pp., $28.00

"By 1938, large parts of the population were using Pervitin on an almost regular basis, including students preparing for exams, nurses on night duty, businessmen under pressure, and mothers dealing with the pressures of Kinder, Küche, Kirche (children, kitchen, church—to which the Nazis thought women should be relegated)... Its consumption came to be seen as entirely normal."

Cliffewiki (talk) 15:42, 20 March 2017 (UTC)[reply]

References

  1. ^ New York Review of Books, March 9, 2017 Issue

Semi-protected edit request on 25 April 2017

Change: Methods of ingestion are Oral, Intravenous, Anal-(rectal), Vaginal and Intra-muscular; to; "Methods of ingestion are Oral, Nasal, Intravenous, Anal-(rectal), Vaginal and Intra-muscular". Purple Chrissy (talk) 02:06, 25 April 2017 (UTC)[reply]

What method is left out of this list? Why don't we just say "it is often injected or ingested but can be administrated by any method" instead of being so oddly and verbosely specific.--45.72.141.216 (talk) 05:34, 8 May 2017 (UTC)[reply]
The ocular route seems to be excluded ;). Sizeofint (talk) 02:40, 9 May 2017 (UTC)[reply]
As is smoking, which I understand is doable. All the more reason to ditch the exhaustive list idea.--45.72.141.216 (talk) 21:20, 10 May 2017 (UTC)[reply]
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