Amdoxovir

Amdoxovir
Clinical data
ATC code	none;
Identifiers
	IUPAC name [(2R,4R)-4-(2,6-diaminopurin-9-yl)-1,3-dioxolan-2-yl]methanol;
CAS Number	145514-04-1 ;
PubChem CID	124088;
ChemSpider	110576 ;
UNII	54I81H0M9C;
KEGG	D02890 ;
ChEMBL	ChEMBL458876 ;
NIAID ChemDB	005431;
CompTox Dashboard (EPA)	DTXSID801027435 ;
Chemical and physical data
Formula	C9H12N6O3
Molar mass	252.234 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n2c1c(nc(nc1n(c2)[C@@H]3O[C@@H](OC3)CO)N)N;
	InChI InChI=1S/C9H12N6O3/c10-7-6-8(14-9(11)13-7)15(3-12-6)4-2-17-5(1-16)18-4/h3-5,16H,1-2H2,(H4,10,11,13,14)/t4-,5-/m1/s1 ; Key:RLAHNGKRJJEIJL-RFZPGFLSSA-N ;
	(verify)

Amdoxovir is a nucleoside reverse transcriptase inhibitor (NRTI) undergoing research for the treatment of HIV/AIDS. It was discovered by Raymond F. Schinazi (Emory University) and C.K. Chu (University of Georgia). It is being developed by RFS Pharma.^[1] Currently, it is in Phase II clinical studies.

References

^ "Amdoxovir". AIDSmeds.com. January 13, 2009. Archived from the original on 2008-03-21. Retrieved March 21, 2008.

Murphy RL, Kivel NM, Zala C, Ochoa C, Tharnish P, Mathew J, Pascual ML, Schinazi RF (2010). "Antiviral activity and tolerability of amdoxovir with zidovudine in a randomized double-blind placebo-controlled study in HIV-1-infected individuals". Antivir Ther. 15 (2): 185–192. doi:10.3851/IMP1514. PMID 20386073.

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