3D model (JSmol)
|Molar mass||886.86 g/mol|
|Appearance||Colorless, crystalline solid|
|Solubility in ethanol, methanol||Soluble|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
Amanullin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. The oral LD50 of amanullin is approximately 20 mg/kg in mice; however, it is non-toxic in humans.
Like other amatoxins, amanullin is an inhibitor of RNA polymerase II. Amanullin has a species dependent and specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).