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BHFF

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This is an old revision of this page, as edited by DePiep (talk | contribs) at 15:23, 2 April 2016 (Remove redundant parameters InChI, InChIKey (StdInChI, StdInChIKey are used). See Talk (via AWB script)). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

BHFF
Identifiers
  • 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.229.838 Edit this at Wikidata
Chemical and physical data
FormulaC17H21F3O3
Molar mass330.341 g/mol g·mol−1
3D model (JSmol)
  • FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O
  • InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 checkY
  • Key:RVNOANDLZIIFHB-UHFFFAOYSA-N checkY
  (verify)

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability.[1]

References

  1. ^ Malherbe, P; Masciadri, R; Norcross, RD; Knoflach, F; Kratzeisen, C; Zenner, MT; Kolb, Y; Marcuz, A; Huwyler, J (2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC 2439845. PMID 18536733.



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