BioCryst Pharmaceuticals

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BioCryst Pharmaceuticals, Inc.
Industry Healthcare
Founded 1986
Headquarters Durham, North Carolina, USA
Key people
Jon P. Stonehouse , President and Chief Executive Officer
Thomas Staab II, Chief Financial Officer
Products Biotechnology
Revenue IncreaseUS$26.3M (FY 2012)[1]
DecreaseUS$-33.9M (FY 2012)[1]
DecreaseUS$-39.1M (FY 2012)[1]
Total assets DecreaseUS$57.4M (FY 2012)[2]
Total equity DecreaseUS$-0.4M (FY 2012)[2]
Number of employees
37 (2013)

BioCryst Pharmaceuticals, Inc. is a pharmaceutical company headquartered in Durham, North Carolina.[3] The company focuses on orphan & autoimmune diseases, and antivirals.[3] The company's most advanced drug candidate is the antiviral Peramivir, which is approved in Japan, Korea and China. It was authorized by the FDA for emergency use in the treatment of patients hospitalized with influenza during the 2009-10 influenza A virus subtype H1N1[4] pandemic.


The company was founded in 1986 by Charles E. Bugg, Ph.D. and John A. Montgomery, Ph.D. In March 1994, BioCryst became a public company when it completed an Initial Public Offering by listing its shares on the NASDAQ stock exchange. In 2008 the company was named one of the fastest growing companies by Deloitte & Touche in its 2008 list of Technology Fast 500.[5]

In October 2010, BioCryst announced its headquarters would move to Durham, North Carolina, where the company has had an office since 2006.[6]

BioCryst is a member of the Alliance for Biosecurity, a group of companies that work to develop vaccines and other measures that can be used in the case of a pandemic or bioterrorism attack.[7][8]


  • Peramivir is an intravenous (i.v.) antiviral drug being developed for the treatment of influenza. BioCryst expects to file for FDA approval before the end of 2013.
  • BCX4161 is an orally administered inhibitor of plasma kallikrein entering Phase 2 development to prevent attacks in hereditary angioedema (HAE) patients.
  • BCX4430 is an RNA dependent-RNA polymerase inhibitor that has demonstrated broad-spectrum activity for multiple viruses. Development of BCX4430 is funded under a U.S. Government contact of up to $22 million granted by the National Institute of Allergy and Infectious Diseases (NIAID) in September 2013.
  • Forodesine HCl, investigational purine nucleoside phosphorylase (PNP) inhibitor for the treatment of T- and B-cell mediated disorders licensed to Mundipharma Research Ltd in Phase 2 development.
  • BCX4208 is a second generation purine nucleoside phosphorylase inhibitor for the treatment of gout that has successfully completed Phase 2 development.


  1. ^ a b c BioCryst Pharmaceuticals (BCRX) annual SEC income statement filing via Wikinvest.
  2. ^ a b BioCryst Pharmaceuticals (BCRX) annual SEC balance sheet filing via Wikinvest.
  3. ^ a b "BioCryst Pharmaceuticals". BioCryst Pharmaceuticals. Retrieved September 26, 2013. 
  4. ^ "Emergency use authorization for the unapproved drug Peramivir" (PDF). U.S. Centers for Disease Control and Prevention. Archived from the original (PDF) on November 22, 2009. Retrieved October 28, 2009. 
  5. ^ BioCryst named 29th fastest growing tech firm Birmingham Business Journal, November 26, 2008
  6. ^ Ranii, David (October 14, 2010). "BioCryst moving HQ to Durham". News & Observer. Archived from the original on October 17, 2010. Retrieved October 14, 2010. 
  7. ^ "Our Members". Alliance for Biosecurity. Retrieved 2017-02-02. 
  8. ^ "Our Mission". Alliance for Biosecurity. Retrieved 2017-02-02. 

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