CRTC3

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CRTC3
Identifiers
Aliases CRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDs MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3
Genetically Related Diseases
inflammatory bowel disease[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042574
NM_022769

NM_173863

RefSeq (protein)

NP_001036039
NP_073606

NP_776288.2
NP_776288

Location (UCSC) Chr 15: 90.53 – 90.65 Mb Chr 7: 80.59 – 80.69 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[4][5][6]

This gene has been shown to be linked to weight gain.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with CRTC3 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081. 
  5. ^ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727Freely accessible. PMID 14506290. 
  6. ^ "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3". 
  7. ^ Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature. 468 (7326): 933–939. doi:10.1038/nature09564. PMID 21164481. 

Further reading[edit]

  • Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry. 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518. 
  • Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674Freely accessible. PMID 16980408. 
  • Koga H, Ohshima T, Shimotohno K (Dec 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry. 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468.  Check date values in: |year= / |date= mismatch (help)
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 

External links[edit]