NCOA5

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NCOA5
Protein NCOA5 PDB 1v95.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NCOA5, CIA, bA465L10.6, nuclear receptor coactivator 5
External IDs MGI: 2385165 HomoloGene: 32496 GeneCards: NCOA5
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020967

NM_144892

RefSeq (protein)

NP_066018
NP_001335077
NP_001335078
NP_001335079
NP_001335080

NP_659141.1
NP_659141

Location (UCSC) Chr 20: 46.06 – 46.09 Mb Chr 2: 165 – 165.03 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.[3][4]

Function[edit]

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.[3]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.