NCOA5

NCOA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V95, 2J7Y, 4ZI1
Identifiers
Aliases	NCOA5, CIA, bA465L10.6, nuclear receptor coactivator 5
External IDs	OMIM: 616825 MGI: 2385165 HomoloGene: 32496 GeneCards: NCOA5
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 164,842,277 bp End 164,876,787 bp
Gene ontology Molecular function protein binding chromatin binding RNA binding Cellular component nucleus actin cytoskeleton extracellular space Biological process negative regulation of insulin receptor signaling pathway regulation of transcription, DNA-templated glucose homeostasis transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57727 228869 Ensembl ENSG00000124160 ENSMUSG00000039804 UniProt Q9HCD5 Q5JY17 Q91W39 RefSeq (mRNA) NM_020967 NM_144892 RefSeq (protein) NP_066018 NP_001335077 NP_001335078 NP_001335079 NP_001335080 NP_659141 Location (UCSC) n/a Chr 2: 164.84 – 164.88 Mb PubMed search
Wikidata
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Nuclear receptor coactivator 5 (NCOA5), also known as coactivator independent of AF-2 function (CIA), is a protein that in humans is encoded by the NCOA5 gene.

Function

This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor Rev-ErbA beta. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Jiang C, Ito M, Piening V, et al. (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi:10.1074/jbc.M401809200. PMID 15073177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Sauvé F, McBroom LD, Gallant J, et al. (2001). "CIA, a Novel Estrogen Receptor Coactivator with a Bifunctional Nuclear Receptor Interacting Determinant". Mol. Cell. Biol. 21 (1): 343–53. doi:10.1128/MCB.21.1.343-353.2001. PMC 88807. PMID 11113208.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

External links

• NCOA5 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C93

This article incorporates text from the United States National Library of Medicine, which is in the public domain.