Cocaine esterase
| Cocaine esterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.84 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cocaine esterase (EC 3.1.1.84, CocE, hCE2, hCE-2, human carboxylesterase 2) is an enzyme with systematic name cocaine benzoylhydrolase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.
References
- ^ Gao, D.; Narasimhan, D.L.; Macdonald, J.; Brim, R.; Ko, M.C.; Landry, D.W.; Woods, J.H.; Sunahara, R.K.; Zhan, C.G. (2009). "Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity". Mol. Pharmacol. 75 (2): 318–323. doi:10.1124/mol.108.049486. PMID 18987161.
- ^ Bresler, M.M.; Rosser, S.J.; Basran, A.; Bruce, N.C. (2000). "Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1". Appl. Environ. Microbiol. 66 (3): 904–908. doi:10.1128/aem.66.3.904-908.2000. PMID 10698749.
- ^ Britt, A.J.; Bruce, N.C.; Lowe, C.R. (1992). "Identification of a cocaine esterase in a strain of Pseudomonas maltophilia". J. Bacteriol. 174 (7): 2087–2094. PMID 1551831.
- ^ Larsen, N.A.; Turner, J.M.; Stevens, J.; Rosser, S.J.; Basran, A.; Lerner, R.A.; Bruce, N.C.; Wilson, I.A. (2002). "Crystal structure of a bacterial cocaine esterase". Nat. Struct. Biol. 9 (1): 17–21. doi:10.1038/nsb742. PMID 11742345.
- ^ Pindel, E.V.; Kedishvili, N.Y.; Abraham, T.L.; Brzezinski, M.R.; Zhang, J.; Dean, R.A.; Bosron, W.F. (1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J. Biol. Chem. 272: 14769–14775. doi:10.1074/jbc.272.23.14769. PMID 9169443.
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External links
- Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol Pharmacol. 2006 Dec;70(6):1885-91. Epub 2006 Sep 12.
- Cocaine+esterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)