Hydroflumethiazide

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Hydroflumethiazide
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Identifiers
  • 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.704 Edit this at Wikidata
Chemical and physical data
FormulaC8H8F3N3O4S2
Molar mass331.29 g/mol g·mol−1
3D model (JSmol)
  • FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N
  • InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) checkY
  • Key:DMDGGSIALPNSEE-UHFFFAOYSA-N checkY
  (verify)

Hydroflumethiazide (or Saluron) is a diuretic.

Synthesis

Hydroflumethiazide synthesis:[1][2][3] Numerous patents, e.g., Lund et al., U.S. patent 3,254,076 (1966 to Lövens Kemiske Fabrik).

See also

References

  1. ^ Holdrege, C. T.; Babel, R. B.; Cheney, L. C. (1959). "Synthesis of Trifluoromethylated Compounds Possessing Diuretic Activity1". Journal of the American Chemical Society. 81 (18): 4807. doi:10.1021/ja01527a015.
  2. ^ Close, W. J.; Swett, L. R.; Brady, L. E.; Short, J. H.; Vernsten, M. (1960). "Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society. 82 (5): 1132. doi:10.1021/ja01490a028.
  3. ^ Novello, F. C.; Bell, S. C.; Abrams, E. L. A.; Ziegler, C.; Sprague, J. M. (1960). "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of Organic Chemistry. 25 (6): 970. doi:10.1021/jo01076a028.


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