Indapamide

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Indapamide
Indapamide.svg
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a684062
Pregnancy
category
  • AU: C
  • US: B (No risk in non-human studies)
Routes of
administration
Oral tablet
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Pharmacokinetic data
Protein binding 71–79%
Metabolism Hepatic
Biological half-life 14–18 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.043.633
Chemical and physical data
Formula C16H16ClN3O3S
Molar mass 365.835 g/mol
3D model (JSmol)
  (verify)

Indapamide is a thiazide-like diuretic[1] drug marketed by Servier, generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available.

Form and composition[edit]

Indapamide is available generically as 1.25 mg and 2.5 mg non-scored tablets.[2] It is now also available in SR (sustained release) form.

Indications[edit]

Hypertension and edema due to congestive heart failure. Indapamide has been proven in the HYVET trial to reduce stroke and all cause mortality when given with or without perindopril to people over the age of 80 for the treatment of hypertension.[3]

Dosage and administration[edit]

The adult dosage is 1.25 to 5 mg, orally and once daily, usually in the morning.

Contraindications[edit]

Indapamide is contraindicated in known hypersensitivity to sulfonamides, severe kidney failure, hepatic encephalopathy or severe liver failure, and a low blood potassium level.

There is insufficient safety data to recommend indapamide use in pregnancy or breastfeeding.

Interactions[edit]

Caution is advised in the combination of indapamide with lithium and nonantiarrhythmic drugs causing wave-burst arrhythmia (astemizole, bepridil, IV erythromycin, halofantrine, pentamidine, sultopride, terfenadine, vincamine).

Precautions[edit]

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or a sensitivity to hypokalemia and in patients with gout.

Adverse effects[edit]

Commonly reported adverse events are hypokalemia (low potassium levels), fatigue, orthostatic hypotension (blood pressure decrease on standing up) and allergic manifestations.

Overdosage[edit]

Symptoms of overdosage would be those associated with a diuretic effect, i.e. electrolyte disturbances, hypotension, and muscular weakness. Treatment should be symptomatic, directed at correcting electrolyte abnormalities.

See also[edit]

References[edit]

  1. ^ Indapamide at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ "Lexicomp Online Login". lexi.com. 
  3. ^ Beckett, NS; Peters, R; Fletcher, AE; et al. (May 2008). "HYVET Trial". N. Engl. J. Med. 358: 1887–98. PMID 18378519. doi:10.1056/NEJMoa0801369.