Hydroxymethylglutaryl-CoA hydrolase
| hydroxymethylglutaryl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.5 | ||||||||
| CAS no. | 9025-89-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a hydroxymethylglutaryl-CoA hydrolase (EC 3.1.2.5) is an enzyme that catalyzes the chemical reaction
- (S)-3-hydroxy-3-methylglutaryl-CoA + H2O CoA + 3-hydroxy-3-methylglutarate
Thus, the two substrates of this enzyme are (S)-3-hydroxy-3-methylglutaryl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-3-methylglutarate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is (S)-3-hydroxy-3-methylglutaryl-CoA hydrolase. Other names in common use include beta-hydroxy-beta-methylglutaryl coenzyme A hydrolase, beta-hydroxy-beta-methylglutaryl coenzyme A deacylase, hydroxymethylglutaryl coenzyme A hydrolase, hydroxymethylglutaryl coenzyme A deacylase, and 3-hydroxy-3-methylglutaryl-CoA hydrolase.
References
- DEKKER EE, SCHLESINGER MJ, COON MJ (1958). "beta-Hydroxy-beta-methylglutaryl coenzyme A deacylase". J. Biol. Chem. 233 (2): 434–8. PMID 13563516.