L-ornithine N5 monooxygenase
|L-ornithine N5 monooxygenase|
Ornithine monooxygenase tetramer, Aspergillus fumigatus
|PDB structures||RCSB PDB PDBe PDBsum|
- L-ornithine + NAD(P)H + O2 N(5)-hydroxy-L-ornithine + NAD(P)+ + H2O
This enzyme belongs to the family of oxidoreductases, specifically the monooxygenases. The systematic name of this enzyme class is L-ornithine N5 monooxygenase (flavin-dependent). The enzyme from the pathogenic fungus Aspergillus fumigatus catalyzes a step in the biosynthesis of the siderophores triacetylfusarinine and desferriferricrocin, while the enzyme from the bacterium Kutzneria 744 is involved in the biosynthesis of piperazate, a building block of the kutzneride family of antifungal antibiotics.
- Franceschini S, Fedkenheuer M, Vogelaar NJ, Robinson HH, Sobrado P, Mattevi A (2012). "Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases". Biochemistry. 51: 7043–5. doi:10.1021/bi301072w. PMID 22928747.
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