NLRP11

NLRP11
Identifiers
Aliases	NLRP11, CLR19.6, NALP11, NOD17, PAN10, PYPAF6, PYPAF7, NLR family, pyrin domain containing 11, NLR family pyrin domain containing 11
External IDs	OMIM: 609664 HomoloGene: 64817 GeneCards: NLRP11
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42-q13.43 Start 55,785,397 bp End 55,836,800 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right lobe of liver testicle islet of Langerhans lymph node gallbladder renal cortex thymus rectum appendix n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 204801 n/a Ensembl ENSG00000179873 n/a UniProt P59045 n/a RefSeq (mRNA) NM_145007 NM_001297743 n/a RefSeq (protein) NP_001284672 NP_659444 n/a Location (UCSC) Chr 19: 55.79 – 55.84 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

NLRP11, short for NOD-like receptor family pyrin domain containing 11, is an intracellular protein of mammals. It is also known as NALP11, PYPAF6, NOD17, PAN10, and CLR19.6, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors. The function of NLRP11 is currently unknown.

Further reading

• Dowds TA, Masumoto J, Chen FF, et al. (2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073.
• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Baranzini SE, Wang J, Gibson RA, et al. (2009). "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis". Hum. Mol. Genet. 18 (4): 767–78. doi:10.1093/hmg/ddn388. PMID 19010793.
• Grenier JM, Wang L, Manji GA, et al. (2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869.
• Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.{{cite journal}}: CS1 maint: unflagged free DOI (link)