NLRP10

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NLRP10
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NLRP10, CLR11.1, NALP10, NOD8, PAN5, PYNOD, NLR family, pyrin domain containing 10, NLR family pyrin domain containing 10
External IDs MGI: 2444084 HomoloGene: 18468 GeneCards: NLRP10
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_176821

NM_175532

RefSeq (protein)

NP_789791

NP_780741.1
NP_780741

Location (UCSC) Chr 11: 7.96 – 7.97 Mb Chr 7: 108.92 – 108.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP8 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.[3][4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Wang Y, Hasegawa M, Imamura R, et al. (June 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777–86. doi:10.1093/intimm/dxh081. PMID 15096476. 
  4. ^ Imamura R, Wang Y, Kinoshita T, et al. (May 2010). "Anti-inflammatory activity of PYNOD and its mechanism in humans and mice". J. Immunol. 184 (10): 5874–84. doi:10.4049/jimmunol.0900779. PMID 20393137. 

Further reading[edit]