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NLR family, CARD domain containing 3
Symbols NLRC3 ; CLR16.2; NOD3
External IDs OMIM615648 MGI2444070 HomoloGene18720 IUPHAR: 1764 GeneCards: NLRC3 Gene
Species Human Mouse
Entrez 197358 268857
Ensembl ENSG00000167984 ENSMUSG00000049871
UniProt Q7RTR2 Q5DU56
RefSeq (mRNA) NM_178844 NM_001081280
RefSeq (protein) NP_849172 NP_001074749
Location (UCSC) Chr 16:
3.54 – 3.58 Mb
Chr 16:
3.95 – 3.98 Mb
PubMed search [1] [2]

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[1] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[2]


  1. ^ Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998. 
  2. ^ Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.