NLRC3

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NLRC3
Identifiers
AliasesNLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDsMGI: 2444070 HomoloGene: 18720 GeneCards: NLRC3
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NLRC3
Genomic location for NLRC3
Band16p13.3Start3,539,033 bp[1]
End3,577,400 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178844

NM_001081280
NM_175547

RefSeq (protein)

NP_849172

NP_001074749
NP_780756

Location (UCSC)Chr 16: 3.54 – 3.58 MbChr 16: 3.95 – 3.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system.[5] It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167984 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049871 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772Freely accessible. PMID 18341998. 
  6. ^ Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.