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Available structures
PDB Ortholog search: PDBe RCSB
Aliases NLRC5, CLR16.1, NOD27, NOD4, NLR family, CARD domain containing 5, NLR family CARD domain containing 5
External IDs MGI: 3612191 HomoloGene: 88935 GeneCards: NLRC5
Genetically Related Diseases
schizophrenia, bipolar disorder[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 56.99 – 57.08 Mb Chr 8: 94.43 – 94.53 Mb
PubMed search [2] [3]
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NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.[4][5][6]

Recently, NLRC5 has been suggested to play a positive role in the regulation of Major Histocompatibility Class I (MHCI) molecule expression.[7] This aspect of NLRC5 function was further investigated with the help of Nlrc5-deficient mice, which showed reduced MHCI expression in lymphocytes (particularly T, NK and NKT lymphocytes).[8] In lymphocytes, NLRC5 localizes to the nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters.[8]

In humans, the NLRC5 protein is encoded by the NLRC5 gene.[9] It has also been called NOD27, NOD4, and CLR16.1.


  1. ^ "Diseases that are genetically associated with NLRC5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Neerincx A, Lautz K, Menning M, et al. (June 2010). "A Role for the Human Nucleotide-binding Domain, Leucine-rich Repeat-containing Family Member NLRC5 in Antiviral Responses". J Biol Chem. 285 (34): 26223–32. doi:10.1074/jbc.M110.109736. PMC 2924034Freely accessible. PMID 20538593. 
  5. ^ Cui J, Zhu L, Xia X, et al. (April 2010). "NLRC5 negatively regulates the NF-κB and type I interferon signaling pathways and antiviral immunity". Cell. 141 (3): 483–96. doi:10.1016/j.cell.2010.03.040. PMC 3150216Freely accessible. PMID 20434986. 
  6. ^ Kuenzel S, Till A, Winkler M, et al. (February 2010). "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses". J. Immunol. 184 (4): 1990–2000. doi:10.4049/jimmunol.0900557. PMID 20061403. 
  7. ^ Meissner, TB; Li, A; Biswas, A; Lee, K; Liu, Y; Bayir, E; Iliopoulos, D; van den Elsen, PJ; Kobayashi, KS (August 2010). "NLR family member NLRC5 is a transcriptional regulator of MHC class I genes". Proc. Natl. Acad. Sci. 107 (31): 13794–13799. doi:10.1073/pnas.1008684107. PMC 2922274Freely accessible. PMID 20639463. 
  8. ^ a b Staehli, F; Ludigs, K; Heinz, LX; Seguín-Estévez, Q; Ferrero, I; Braun, M; Schroder, K; Rebsamen, M; Tardivel, A; Mattmann, C; MacDonald, HR; Romero, P; Reith, W; Guarda, G; Tschopp, J (April 2012). "NLRC5 Deficiency Selectively Impairs MHC Class I-Dependent Lymphocyte Killing by Cytotoxic T Cells". J Immunol. 188 (8): 3820–8. doi:10.4049/jimmunol.1102671. PMID 22412192. Retrieved 23 March 2012. 
  9. ^ Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N, Núñez G (March 2003). "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product". Biochem. Biophys. Res. Commun. 302 (3): 575–80. doi:10.1016/S0006-291X(03)00221-3. PMID 12615073.