NLRC5, short for NOD-like receptor family CARD domain containing 5, is an intracellular protein that plays a role in the immune system. NLRC5 is a pattern recognition receptor implicated in innate immunity to viruses potentially by regulating interferon activity.   
Recently, NLRC5 has been suggested to play a positive role in the regulation of
Major Histocompatibility Class I (MHCI) molecule expression. This aspect of NLRC5 function was further investigated with the help of  Nlrc5- deficient mice, which showed reduced MHCI expression in lymphocytes (particularly T, NK and NKT lymphocytes). In lymphocytes, NLRC5 localizes to the  nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters. 
In humans, the NLRC5
protein is encoded by the NLRC5 gene. It has also been called NOD27, NOD4, and CLR16.1. 
References [ edit ]
^ "Diseases that are genetically associated with NLRC5 view/edit references on wikidata".
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^ "Mouse PubMed Reference:".
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