Princess Margaretha is the twin sister of Prince Jean of Luxembourg. She was educated in the Grand Duchy, where she studied at the Ecole Européenne de Luxembourg, as well as in Belgium (her mother's native land), Great Britain and in the United States. She speaks Luxembourgeois, French, English and German, having spent time in numerous countries as either student or tourist. She has acquired a doctorate in the social sciences.
Princess Margaretha is the patron of Dyslexia International. She is also the Patroness of the Princess Margaretha Luxembourgeois Girl Guides of Leudelange and of the Crèche de Luxembourg. She travels frequently between her home in Liechtenstein, her native Luxembourg, Brussels, where she attends conferences and meetings related to the EU-NGO in which she remains actively involved. Other travel includes visits abroad with her husband, such as their 2011 visit to the University of Dallas where the couple was hosted and interviewed on campus.
Her main recreational interests and sport activities include riding, skiing, tennis, hunting, reading and modern and classical music. Her reading emphasizes historical biographies and spiritual works.
In 2011 Grand Duke Henri decreed that his female descendants would henceforth enjoy the right of succession to the throne without regard to gender, in accordance with absolute primogeniture. Other princesses of the dynasty, descended from prior sovereigns, may still inherit the throne in the event of extinction of all male dynasts and of all dynasts descended from Grand Duke Henri, and in the order stipulated by the 1907 amendment to the 1783 Nassau Family Pact
^de Badts de Cugnac, Chantal. Coutant de Saisseval, Guy. Le Petit Gotha. Nouvelle Imprimerie Laballery, Paris 2002, pp. 665-666 (French) ISBN 2-9507974-3-1
^de Badts de Cugnac, Chantal. Coutant de Saisseval, Guy. Le Petit Gotha. Nouvelle Imprimerie Laballery, Paris 2002, pp. 632-634, 653, 666-668, 681-682 (French) ISBN 2-9507974-3-1
^Honorary distinctions of the Grand Duchy of Luxembourg, publication of the government of Luxembourg: Princes and Princesses of the Grand-Ducal House of Luxembourg are Grand Crosses of the Order by birth but the decoration is worn only after they reach their majority (18 years old)
^Belga Pictures, Photo showing Princess Margaretha and her husband Nikolaus of Liechtenstein wearing the order decorations (Gala diner gallery)