SOCS3

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Template:PBB Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene.[1][2]

Template:PBB Summary

Interactions

SOCS3 has been shown to interact with PTPN11,[3] Glycoprotein 130,[3] Erythropoietin receptor,[4][5] Janus kinase 2,[2][4][6] RAS p21 protein activator 1[7] and Insulin-like growth factor 1 receptor.[8]

Regulation

There is some evidence that the expression of SOCS3 is regulated by the microRNA miR-203.[9][10]

See also

References

  1. ^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.{{cite journal}}: CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid9344848" was defined multiple times with different content (see the help page).
  3. ^ a b Lehmann, Ute (January 2003). "SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130". J. Biol. Chem. 278 (1). United States: 661–71. doi:10.1074/jbc.M210552200. ISSN 0021-9258. PMID 12403768. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  4. ^ a b Sasaki, A; Yasukawa H; Shouda T; Kitamura T; Dikic I; Yoshimura A (September 2000). "CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2". J. Biol. Chem. 275 (38). UNITED STATES: 29338–47. doi:10.1074/jbc.M003456200. ISSN 0021-9258. PMID 10882725. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
  5. ^ Hörtner, Michael; Nielsch Ulrich; Mayr Lorenz M; Heinrich Peter C; Haan Serge (May 2002). "A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor". Eur. J. Biochem. 269 (10). Germany: 2516–26. doi:10.1046/j.1432-1033.2002.02916.x. ISSN 0014-2956. PMID 12027890. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
  6. ^ Sasaki, A; Yasukawa H; Suzuki A; Kamizono S; Syoda T; Kinjyo I; Sasaki M; Johnston J A; Yoshimura A (June 1999). "Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain". Genes Cells. 4 (6). ENGLAND: 339–51. doi:10.1046/j.1365-2443.1999.00263.x. ISSN 1356-9597. PMID 10421843. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help); Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
  7. ^ Cacalano, N A; Sanden D; Johnston J A (May 2001). "Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras". Nat. Cell Biol. 3 (5). England: 460–5. doi:10.1038/35074525. ISSN 1465-7392. PMID 11331873. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
  8. ^ Dey, B R; Furlanetto R W; Nissley P (November 2000). "Suppressor of cytokine signaling (SOCS)-3 protein interacts with the insulin-like growth factor-I receptor". Biochem. Biophys. Res. Commun. 278 (1). UNITED STATES: 38–43. doi:10.1006/bbrc.2000.3762. ISSN 0006-291X. PMID 11071852. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
  9. ^ Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G, Candi E (2008). "miR-203 represses 'stemness' by repressing DeltaNp63". Cell Death Differ. 15 (7): 1187–95. doi:10.1038/cdd.2008.69. PMID 18483491.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. ^ Wei T, Orfanidis K, Xu N, Janson P, StÃ¥hle M, Pivarcsi A, Sonkoly E (2010). "The expression of microRNA-203 during human skin morphogenesis". Exp Dermatol. 19 (9): 854–6. doi:10.1111/j.1600-0625.2010.01118.x. PMID 20698882.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

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