|Smoker's melanosis in gums base|
|Classification and external resources|
Smoker's melanosis is seen with the naked eye as a brown to black pigmentation of the oral tissue i.e. the gums, cheeks or palate  as well as in larynx. It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of a genetically caused melanin pigmentation. However, it is also frequently reported from countries with genetically melanin-pigmented inhabitants and besides cigarette- and pipe smokers also in chutta, bidi users and reverse smokers (see "Incidence").
The brown to black colour is melanin. In skin, melanin prevents harmful UV-light from reaching deeper, sensible parts of the tissue. If UV-light penetrates deep, some of the toxic substances due to the UV-light damage to the cells, are bound to melanin in the epithelial cells and travel with the ageing cells to the skin surface, where they are expelled from the tissue surface. In this way the melanocytes and kerationocytes together protect the tissue with melanin serving as a toxic defence- and cleaning agent.
In the oral mucosa, where the ageing epithelial cells move faster to the surface compared to skin, a similar defence-mechanism seems to be present, but here acting to clean the mucosa from different toxic chemicals entering the mouth. Besides chemicals in tobacco also antimalaria-drugs cause an oral pigmentation. Smoker's melanosis is like the genetic melanin pigmentations a defence-system in action.
The microscope shows smoker's melanosis to be characterized by a melanin hyperpigmentation of the lower part of the oral epithelium, similar to sun-tanned skin. The hyperpigmentation consists of melanin granules which have the shape and colour of "coffea beans". They are produced by the dendritic, octopus-like melanocytes, seen between the epithelial cells situated closest to the epithelium/connective tissue border.
In tobacco-users the melanocytes are stimulated to produce melanin granules and to distribute them out to the surrounding epithelial cells for further transport to the mucosal surface, like the mechanism in melanin-pigmented skin.
Small amounts of melanin-like granules together with other electrone-dense particles can also be seen within large melanosome complexes in the underlying connective tissue. If the granules derive from the epithelium, a phenomenon known as melanin incontinence, is not known. In Caucasians these granules are not expected to influence on the clinically observed degree of smoker's melanosis.
Smoking or the use of nicotine-containing drugs is the cause to Smoker's melanosis,. Also tar-components (benzopyrenes) are known to stimulate melanocytes to melanin production, and other unknown toxic agents in tobacco may also be the cause. These chemical agents have a polycyclic, chain-like structure. Environmental tobacco smoke from parents is causing smoker's melanosis in their children  Swedish snuff causes a small elevation of oral melanin pigmented individuals from 3.0% to 4.7%. Nicotine tablets have shown to stimulate to melanin pigmentation of the oral mucosa.
Treatment and prognosis
Lesions usually disappear between 3 months to 3 years for those who stop smoking. Smoker's melanosis is a benign, normal physiological reaction, and does not develop into cancer. If it does not disappear, however, a biopsy can verify the diagnosis. If Smoker's melanosis is destroyed by excessive smoking, as in the hard palate of reverse smokers, who smoke with the glowing part of the cigarette inside the mouth for different reasons, a pale depigmented surface is first seen, indicating the loss of the protecting melanin. Then a red inflammation sometimes occurs and cancer development may follow. In reverse smokers it is important to inspect regularly the areas with smoker's melanosis to detect any melanin destruction, in order to stop smoking in time and thus prevent a cancer to develop.
A study in Sweden showed that 21.5% of smokers and 3% of nonsmokers (genetic pigmentation or unknown cause) had lesions that could be classified as an oral melanin pigmentation. A gingival melanin index in 4 degrees was established. Already with a consumption of 1-3 cigarettes a day 9.3% of all 20.333 examined showed a smoker's melanosis. Pipe smokers had smoker's melanosis in 16.8%. One year after the start of cigarette smoking a clinically visible smoker's melanosis could be seen in 12.3% of women, and 17% among men.
In cigarette smokers who quit smoking, the number of individuals with smoker's melanosis becomes slowly less frequent after 2–3 months, but can still be seen in a few former smokers three years after smoking stop.
Although clinically visible genetic melanin pigmentations in the mouth are present in several ethnic groups all over the world, more mucosal areas will be melanin-pigmentet if tobacco products are used. Smoker's melanosis is found in India, Italy, Japan, Nigeria, Sweden, Turkey, USA, and several other countries.
Smoker's melanosis is expected to be found also in other tissue surfaces exposed to tobacco and tobacco smoke, for instance lips and in skin of the fingers holding the cigarette. Future studies will also show if the use of tobacco exaggerates the pigmentation of skin.
- Hedin CA: Smoker's Melanosis. An epidemiologic, morphologic and experimental study of oral melanin pigmentation caused by tobacco. Thesis, University of Lund, Sweden 1986.
- Axéll T, Hedin CA: Epidemiologic study of excessive oral melanin pigmentation with special reference to the influence of tobacco habits. Scand J Dent Res 1982; 90:434-442.
- Gonzalez-Vela MC, Fernandez FA, Mayorga M, Rodriguez-Iglesias J, Val-Bernal JF: Laryngeal melanosis: report of four cases and literature review. Otolaryngol Head Neck Surg 1997; 117:708-712.
- Cordes S, Halum S, Hansen L: Laryngeal melanosis. Otolaryngol Head Neck Surg 2013; 149:733-738.
- Hedin CA: Smoker's Melanosis. Occurrence and localization in the attached gingiva. Arch Dermatol 1977; 113:1533-1538.
- Hedin CA, Larsson Å: The ultrastructure of the gingival epithelium in smoker's melanosis. J Periodont Res 1984; 19:177-190.
- Hedin CA, Larsson Å: Large melanosome complexes in the human gingival epithelium. J Periodont Res 1987; 22:108-113.
- Sapp JP, Eversole LR, Wysock GPi: Contemporary Oral and Maxillofacial Pathology. Chapter 6 - Epithelial Disorders. Published by Mosby,1997; St. Louis, MO.
- Hedin CA, Larsson Å: In vitro activation of amphibian dermal melanocytes by nicotine. Scand J Dent Res 1986; 94:57-65.
- Wallstrom M, Sand L, Nilsson F, Hirsch JM: The long-term effect of nicotine on the oral mucosa. Addiction 1999; 94:417-423.
- Sridharan S, Ganiger K, Satyanarayana A, Rahul A, Shetty S: Effect of environmental tobacco smoke from smoker parents on gingival pigmentation in children and young adults: a cross-sectional study. J Periodontol 2011; 82:956-962.
- Hanioka T,Tanaka K, Ojima M, Yuuki K: Association of melanin pigmentation in the gingiva of children with parents who smoke. Pediatrics 2005; 116:186-190.
- Hedin CA, Pindborg JJ, Axéll T: Depigmentation of smoker's melanosis after smoking-stop. J Oral Pathol Med 1993;22:228-230.
- Hedin CA, Pindborg JJ, Daftary DK, Mehta FS: Melanin depigmentation of the palatal mucosa in reverse smokers. J Oral Pathol Med 1992; 21:440 444.
- Pentenero M, Broccoletti R, Carbone M, Conrotto D, Gandolfo S: The prevalence of oral mucosal lesions in adults from the Turin area. Oral Dis 2008; 14:356-366.
- Araki S, Murata K, Ushio K, Sakai R: Dose-Response relationship between tobacco consumption and melanin pigmentation in the attached gingiva. Arch Environ Health 1983; 38:375-378.
- Nwhator SO, Winfunke-Savage K, Ayanbadejo P, Jeboda SO: Smoker's melanosis in a Nigerian population: a preliminary study. J Contemp Dent Pract 2007; 1:68-75.
- Unsal E, Pakosy C, Soykan E, Elhan AH, Sahin M: Oral melanin pigmentation related to smoking in a Turkish population. Community Dent Oral Epidemiol 2001; 29:272.277.
- Marakoglu K, Gursoy UK, Toker HC, Demirer S, Sezer RE, Marakoglu I: Smoking status and smoke-related gingival melanin pigmentation in army recruitments. Mil Med 2007; 172:110-113.
- Natali C, Curtis JL, Suarez L, Millman EJ: Oral mucosa pigment changes in heavy drinkers and smokers. J Natl Med Assoc 1991; 83:434-438.
- Taybos G: Oral changes associated with tobacco use. Am J Med Sci 2003; 326:179-182.
- Hedin CA, Axéll T: Oral melanin pigmentation in 467 Thai and Malaysian people with special emphasis on smoker's melanosis. J Oral Pathol Med 1991; 20:8-12.