Tuberculosinol synthase
| Tuberculosinol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC no. | 3.1.7.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tuberculosinol synthase (EC 3.1.7.8, Rv3378c) is an enzyme with systematic name tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming).[2][3] This enzyme catalyses the following chemical reaction
- tuberculosinyl diphosphate + H2O [tuberculosinol] + diphosphate
This enzyme is present in Mycobacterium that cause tuberculosis.
References
- ^ Layre, E; Lee, H. J.; Young, D. C.; Jezek Martinot, A; Buter, J; Minnaard, A. J.; Annand, J. W.; Fortune, S. M.; Snider, B. B.; Matsunaga, I; Rubin, E. J.; Alber, T; Moody, D. B. (2014). "Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c". Proceedings of the National Academy of Sciences. 111 (8): 2978–83. doi:10.1073/pnas.1315883111. PMID 24516143.
- ^ Nakano, C.; Ootsuka, T.; Takayama, K.; Mitsui, T.; Sato, T.; Hoshino, T. (2011). "Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome". Biosci. Biotechnol. Biochem. 75: 75–81. doi:10.1271/bbb.100570. PMID 21228491.
- ^ Hoshino, T.; Nakano, C.; Ootsuka, T.; Shinohara, Y.; Hara, T. (2011). "Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis". Org. Biomol. Chem. 9: 2156–2165. doi:10.1039/c0ob00884b. PMID 21290071.
External links
- Tuberculosinol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)