Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 09:38, 9 November 2007 (UTC)
[edit]Proteins without matches (18)
[edit]Proteins with a High Potential Match (7)
[edit]Manual Inspection (Page not found) (18)
[edit]
Protein Status Grid - Date: 09:38, 9 November 2007 (UTC)
[edit]Vebose Log - Date: 09:38, 9 November 2007 (UTC)
[edit]- INFO: Beginning work on ATF1... {November 9, 2007 1:06:42 AM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 1:07:18 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:07:30 AM PST}
- CREATED: Created new protein page: ATF1 {November 9, 2007 1:07:37 AM PST}
- INFO: Beginning work on AXL... {November 9, 2007 1:07:37 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein AXL image.jpg {November 9, 2007 1:08:33 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:08:47 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_AXL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2c5d.
| PDB = {{PDB2|2c5d}}
| Name = AXL receptor tyrosine kinase
| HGNCid = 905
| Symbol = AXL
| AltSymbols =; UFO
| OMIM = 109135
| ECnumber =
| Homologene = 7583
| MGIid = 1347244
| GeneAtlas_image1 = PBB_GE_AXL_202686_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_AXL_202685_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 558
| Hs_Ensembl = ENSG00000167601
| Hs_RefseqProtein = NP_001690
| Hs_RefseqmRNA = NM_001699
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 46416663
| Hs_GenLoc_end = 46459510
| Hs_Uniprot = P30530
| Mm_EntrezGene = 26362
| Mm_Ensembl = ENSMUSG00000002602
| Mm_RefseqmRNA = NM_009465
| Mm_RefseqProtein = NP_033491
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 25466034
| Mm_GenLoc_end = 25497330
| Mm_Uniprot = Q3TTM4
}}
}}
'''AXL receptor tyrosine kinase''', also known as '''AXL''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduce signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.<ref>{{cite web | title = Entrez Gene: AXL AXL receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=558| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Neubauer A, Burchert A, Maiwald C, ''et al.'' |title=Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias. |journal=Leuk. Lymphoma |volume=25 |issue= 1-2 |pages= 91-6 |year= 1997 |pmid= 9130617 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCL21... {November 9, 2007 1:27:15 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:27:57 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) ligand 21
| HGNCid = 10620
| Symbol = CCL21
| AltSymbols =; 6Ckine; CKb9; ECL; MGC34555; SCYA21; SLC; TCA4
| OMIM = 602737
| ECnumber =
| Homologene = 88457
| MGIid =
| GeneAtlas_image1 = PBB_GE_CCL21_204606_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6366
| Hs_Ensembl = ENSG00000137077
| Hs_RefseqProtein = NP_002980
| Hs_RefseqmRNA = NM_002989
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 34699002
| Hs_GenLoc_end = 34700147
| Hs_Uniprot = O00585
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Chemokine (C-C motif) ligand 21''', also known as '''CCL21''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).<ref>{{cite web | title = Entrez Gene: CCL21 chemokine (C-C motif) ligand 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6366| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CXCL9... {November 9, 2007 1:13:21 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:13:58 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-X-C motif) ligand 9
| HGNCid = 7098
| Symbol = CXCL9
| AltSymbols =; CMK; Humig; MIG; SCYB9; crg-10
| OMIM = 601704
| ECnumber =
| Homologene = 1813
| MGIid = 1352449
| GeneAtlas_image1 = PBB_GE_CXCL9_203915_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4283
| Hs_Ensembl = ENSG00000138755
| Hs_RefseqProtein = NP_002407
| Hs_RefseqmRNA = NM_002416
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 77141523
| Hs_GenLoc_end = 77147648
| Hs_Uniprot = Q07325
| Mm_EntrezGene = 17329
| Mm_Ensembl = ENSMUSG00000029417
| Mm_RefseqmRNA = NM_008599
| Mm_RefseqProtein = NP_032625
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 93398190
| Mm_GenLoc_end = 93403317
| Mm_Uniprot =
}}
}}
'''Chemokine (C-X-C motif) ligand 9''', also known as '''CXCL9''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The function of this gene has not been specifically defined; however, it is thought to be involved in T cell trafficking. This gene has been localized to 4q21 with INP10, which is also a member of the chemokine family of cytokines.<ref>{{cite web | title = Entrez Gene: CXCL9 chemokine (C-X-C motif) ligand 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4283| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HNRPU... {November 9, 2007 1:08:47 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:10:08 AM PST}
- CREATED: Created new protein page: HNRPU {November 9, 2007 1:10:16 AM PST}
- INFO: Beginning work on KRT10... {November 9, 2007 1:10:16 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:11:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)
| HGNCid = 6413
| Symbol = KRT10
| AltSymbols =; CK10; K10; KPP
| OMIM = 148080
| ECnumber =
| Homologene = 20125
| MGIid = 96685
| GeneAtlas_image1 = PBB_GE_KRT10_213287_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KRT10_207023_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_KRT10_210633_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030280 |text = structural constituent of epidermis}}
| Component = {{GNF_GO|id=GO:0045095 |text = keratin filament}}
| Process = {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3858
| Hs_Ensembl = ENSG00000186395
| Hs_RefseqProtein = NP_000412
| Hs_RefseqmRNA = NM_000421
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 36227896
| Hs_GenLoc_end = 36232373
| Hs_Uniprot = P13645
| Mm_EntrezGene = 16661
| Mm_Ensembl = ENSMUSG00000019761
| Mm_RefseqmRNA = NM_010660
| Mm_RefseqProtein = NP_034790
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 99201344
| Mm_GenLoc_end = 99205454
| Mm_Uniprot = P02535
}}
}}
'''Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)''', also known as '''KRT10''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.<ref>{{cite web | title = Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3858| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Yang JM, Nam K, Kim SW, ''et al.'' |title=Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis. |journal=J. Dermatol. Sci. |volume=19 |issue= 2 |pages= 126-33 |year= 1999 |pmid= 10098704 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LMNB1... {November 9, 2007 1:11:52 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:12:29 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lamin B1
| HGNCid = 6637
| Symbol = LMNB1
| AltSymbols =; LMN; LMN2; LMNB; MGC111419
| OMIM = 150340
| ECnumber =
| Homologene = 55912
| MGIid = 96795
| GeneAtlas_image1 = PBB_GE_LMNB1_203276_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005638 |text = lamin filament}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4001
| Hs_Ensembl = ENSG00000113368
| Hs_RefseqProtein = NP_005564
| Hs_RefseqmRNA = NM_005573
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 126140214
| Hs_GenLoc_end = 126200582
| Hs_Uniprot = P20700
| Mm_EntrezGene = 16906
| Mm_Ensembl = ENSMUSG00000024590
| Mm_RefseqmRNA = XM_993305
| Mm_RefseqProtein = XP_998399
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 56833233
| Mm_GenLoc_end = 56878791
| Mm_Uniprot = Q8C553
}}
}}
'''Lamin B1''', also known as '''LMNB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.<ref>{{cite web | title = Entrez Gene: LMNB1 lamin B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4001| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gruenbaum Y, Wilson KL, Harel A, ''et al.'' |title=Review: nuclear lamins--structural proteins with fundamental functions. |journal=J. Struct. Biol. |volume=129 |issue= 2-3 |pages= 313-23 |year= 2000 |pmid= 10806082 |doi= 10.1006/jsbi.2000.4216 }}
*{{cite journal | author=Worman HJ, Courvalin JC |title=The inner nuclear membrane. |journal=J. Membr. Biol. |volume=177 |issue= 1 |pages= 1-11 |year= 2000 |pmid= 10960149 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LRPAP1... {November 9, 2007 1:12:29 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LRPAP1 image.jpg {November 9, 2007 1:13:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:13:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LRPAP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lre.
| PDB = {{PDB2|1lre}}, {{PDB2|1nre}}, {{PDB2|1op1}}, {{PDB2|1ov2}}, {{PDB2|2fcw}}, {{PDB2|2ftu}}, {{PDB2|2fyl}}
| Name = Low density lipoprotein receptor-related protein associated protein 1
| HGNCid = 6701
| Symbol = LRPAP1
| AltSymbols =; A2MRAP; A2RAP; HBP44; MGC138272; MRAP; RAP
| OMIM = 104225
| ECnumber =
| Homologene = 37612
| MGIid = 96829
| GeneAtlas_image1 = PBB_GE_LRPAP1_201186_at_tn.png
| Function = {{GNF_GO|id=GO:0004873 |text = asialoglycoprotein receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008034 |text = lipoprotein binding}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0050750 |text = low-density lipoprotein receptor binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4043
| Hs_Ensembl = ENSG00000163956
| Hs_RefseqProtein = NP_002328
| Hs_RefseqmRNA = NM_002337
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 3484088
| Hs_GenLoc_end = 3503947
| Hs_Uniprot = P30533
| Mm_EntrezGene = 16976
| Mm_Ensembl = ENSMUSG00000029103
| Mm_RefseqmRNA = NM_013587
| Mm_RefseqProtein = NP_038615
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 35408367
| Mm_GenLoc_end = 35422558
| Mm_Uniprot = Q3TL96
}}
}}
'''Low density lipoprotein receptor-related protein associated protein 1''', also known as '''LRPAP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NDP... {November 9, 2007 1:13:58 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:14:32 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Norrie disease (pseudoglioma)
| HGNCid = 7678
| Symbol = NDP
| AltSymbols =; EVR2; FEVR; ND
| OMIM = 310600
| ECnumber =
| Homologene = 225
| MGIid = 102570
| GeneAtlas_image1 = PBB_GE_NDP_206022_at_tn.png
| Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001890 |text = placenta development}} {{GNF_GO|id=GO:0007033 |text = vacuole organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4693
| Hs_Ensembl = ENSG00000124479
| Hs_RefseqProtein = NP_000257
| Hs_RefseqmRNA = NM_000266
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 43692966
| Hs_GenLoc_end = 43717694
| Hs_Uniprot = Q00604
| Mm_EntrezGene = 17986
| Mm_Ensembl = ENSMUSG00000040138
| Mm_RefseqmRNA = NM_010883
| Mm_RefseqProtein = NP_035013
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 16042480
| Mm_GenLoc_end = 16068723
| Mm_Uniprot = Q5CZY6
}}
}}
'''Norrie disease (pseudoglioma)''', also known as '''NDP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = NDP is the genetic locus identified as harboring mutations that result in Norrie disease. Norrie disease is a rare genetic disorder characterized by bilateral congenital blindness that is caused by a vascularized mass behind each lens due to a maldeveloped retina (pseudoglioma).<ref>{{cite web | title = Entrez Gene: NDP Norrie disease (pseudoglioma)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4693| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berger W, van de Pol D, Warburg M, ''et al.'' |title=Mutations in the candidate gene for Norrie disease. |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 461-5 |year= 1993 |pmid= 1307245 |doi= }}
*{{cite journal | author=Black G, Redmond RM |title=The molecular biology of Norrie's disease. |journal=Eye (London, England) |volume=8 ( Pt 5) |issue= |pages= 491-6 |year= 1995 |pmid= 7835440 |doi= }}
*{{cite journal | author=Masckauchán TN, Kitajewski J |title=Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight. |journal=Physiology (Bethesda, Md.) |volume=21 |issue= |pages= 181-8 |year= 2007 |pmid= 16714476 |doi= 10.1152/physiol.00058.2005 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NUMA1... {November 9, 2007 1:14:32 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:15:21 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear mitotic apparatus protein 1
| HGNCid = 8059
| Symbol = NUMA1
| AltSymbols =; NUMA
| OMIM = 164009
| ECnumber =
| Homologene = 38150
| MGIid = 2443665
| GeneAtlas_image1 = PBB_GE_NUMA1_200747_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NUMA1_214251_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005876 |text = spindle microtubule}}
| Process = {{GNF_GO|id=GO:0000090 |text = mitotic anaphase}} {{GNF_GO|id=GO:0006997 |text = nuclear organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 4926
| Hs_Ensembl = ENSG00000137497
| Hs_RefseqProtein = NP_006176
| Hs_RefseqmRNA = NM_006185
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 71391559
| Hs_GenLoc_end = 71469221
| Hs_Uniprot = Q14980
| Mm_EntrezGene = 101706
| Mm_Ensembl = ENSMUSG00000066306
| Mm_RefseqmRNA = NM_133947
| Mm_RefseqProtein = NP_598708
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 101807932
| Mm_GenLoc_end = 101887774
| Mm_Uniprot =
}}
}}
'''Nuclear mitotic apparatus protein 1''', also known as '''NUMA1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Sun QY, Schatten H |title=Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein. |journal=Front. Biosci. |volume=11 |issue= |pages= 1137-46 |year= 2006 |pmid= 16146802 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on OXTR... {November 9, 2007 1:15:21 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:15:50 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Oxytocin receptor
| HGNCid = 8529
| Symbol = OXTR
| AltSymbols =; OT-R
| OMIM = 167055
| ECnumber =
| Homologene = 20255
| MGIid = 109147
| GeneAtlas_image1 = PBB_GE_OXTR_206825_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004990 |text = oxytocin receptor activity}} {{GNF_GO|id=GO:0005000 |text = vasopressin receptor activity}}
| Component = {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007595 |text = lactation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5021
| Hs_Ensembl = ENSG00000180914
| Hs_RefseqProtein = NP_000907
| Hs_RefseqmRNA = NM_000916
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 8765419
| Hs_GenLoc_end = 8786300
| Hs_Uniprot = P30559
| Mm_EntrezGene = 18430
| Mm_Ensembl = ENSMUSG00000049112
| Mm_RefseqmRNA = XM_001001627
| Mm_RefseqProtein = XP_001001627
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 112442851
| Mm_GenLoc_end = 112455574
| Mm_Uniprot = Q3UPP9
}}
}}
'''Oxytocin receptor''', also known as '''OXTR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.<ref>{{cite web | title = Entrez Gene: OXTR oxytocin receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5021| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kimura T, Ivell R |title=The oxytocin receptor. |journal=Results and problems in cell differentiation |volume=26 |issue= |pages= 135-68 |year= 1999 |pmid= 10453463 |doi= }}
*{{cite journal | author=Cassoni P, Sapino A, Marrocco T, ''et al.'' |title=Oxytocin and oxytocin receptors in cancer cells and proliferation. |journal=J. Neuroendocrinol. |volume=16 |issue= 4 |pages= 362-4 |year= 2004 |pmid= 15089975 |doi= 10.1111/j.0953-8194.2004.01165.x }}
*{{cite journal | author=Devost D, Zingg HH |title=Homo- and hetero-dimeric complex formations of the human oxytocin receptor. |journal=J. Neuroendocrinol. |volume=16 |issue= 4 |pages= 372-7 |year= 2004 |pmid= 15089977 |doi= 10.1111/j.0953-8194.2004.01188.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PBX1... {November 9, 2007 1:15:50 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PBX1 image.jpg {November 9, 2007 1:16:20 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:16:32 AM PST}
- CREATED: Created new protein page: PBX1 {November 9, 2007 1:16:38 AM PST}
- INFO: Beginning work on PFN1... {November 9, 2007 1:16:38 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PFN1 image.jpg {November 9, 2007 1:17:12 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:17:20 AM PST}
- CREATED: Created new protein page: PFN1 {November 9, 2007 1:17:28 AM PST}
- INFO: Beginning work on PKM2... {November 9, 2007 1:17:28 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PKM2 image.jpg {November 9, 2007 1:18:01 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:18:35 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PKM2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a49.
| PDB = {{PDB2|1a49}}, {{PDB2|1a5u}}, {{PDB2|1aqf}}, {{PDB2|1f3w}}, {{PDB2|1f3x}}, {{PDB2|1pkm}}, {{PDB2|1pkn}}, {{PDB2|1t5a}}, {{PDB2|1zjh}}, {{PDB2|2g50}}
| Name = Pyruvate kinase, muscle
| HGNCid = 9021
| Symbol = PKM2
| AltSymbols =; CTHBP; MGC3932; OIP3; PK3; PKM; TCB; THBP1
| OMIM = 179050
| ECnumber =
| Homologene = 37650
| MGIid = 97591
| GeneAtlas_image1 = PBB_GE_PKM2_201251_at_tn.png
| Function = {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004743 |text = pyruvate kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006096 |text = glycolysis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5315
| Hs_Ensembl = ENSG00000067225
| Hs_RefseqProtein = NP_002645
| Hs_RefseqmRNA = NM_002654
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 15
| Hs_GenLoc_start = 70278424
| Hs_GenLoc_end = 70310738
| Hs_Uniprot = P14618
| Mm_EntrezGene = 18746
| Mm_Ensembl = ENSMUSG00000032294
| Mm_RefseqmRNA = XM_979537
| Mm_RefseqProtein = XP_984631
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 59454614
| Mm_GenLoc_end = 59477381
| Mm_Uniprot = Q3TBV8
}}
}}
'''Pyruvate kinase, muscle''', also known as '''PKM2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: PKM2 pyruvate kinase, muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5315| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Garfinkel L, Garfinkel D |title=Magnesium regulation of the glycolytic pathway and the enzymes involved. |journal=Magnesium |volume=4 |issue= 2-3 |pages= 60-72 |year= 1985 |pmid= 2931560 |doi= }}
*{{cite journal | author=Mazurek S, Grimm H, Boschek CB, ''et al.'' |title=Pyruvate kinase type M2: a crossroad in the tumor metabolome. |journal=Br. J. Nutr. |volume=87 Suppl 1 |issue= |pages= S23-9 |year= 2002 |pmid= 11895152 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRKAR2B... {November 9, 2007 1:18:35 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRKAR2B image.jpg {November 9, 2007 1:19:11 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:19:22 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRKAR2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cx4.
| PDB = {{PDB2|1cx4}}
| Name = Protein kinase, cAMP-dependent, regulatory, type II, beta
| HGNCid = 9392
| Symbol = PRKAR2B
| AltSymbols =; PRKAR2; RII-BETA
| OMIM = 176912
| ECnumber =
| Homologene = 37666
| MGIid = 97760
| GeneAtlas_image1 = PBB_GE_PRKAR2B_203680_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0008603 |text = cAMP-dependent protein kinase regulator activity}} {{GNF_GO|id=GO:0030552 |text = cAMP binding}}
| Component = {{GNF_GO|id=GO:0005952 |text = cAMP-dependent protein kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007612 |text = learning}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5577
| Hs_Ensembl = ENSG00000005249
| Hs_RefseqProtein = NP_002727
| Hs_RefseqmRNA = NM_002736
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 106472375
| Hs_GenLoc_end = 106589491
| Hs_Uniprot = P31323
| Mm_EntrezGene = 19088
| Mm_Ensembl = ENSMUSG00000002997
| Mm_RefseqmRNA = NM_011158
| Mm_RefseqProtein = NP_035288
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 32543731
| Mm_GenLoc_end = 32646499
| Mm_Uniprot = Q3V2X9
}}
}}
'''Protein kinase, cAMP-dependent, regulatory, type II, beta''', also known as '''PRKAR2B''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.<ref>{{cite web | title = Entrez Gene: PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5577| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Harrich D, McMillan N, Munoz L, ''et al.'' |title=Will diverse Tat interactions lead to novel antiretroviral drug targets? |journal=Current drug targets |volume=7 |issue= 12 |pages= 1595-606 |year= 2007 |pmid= 17168834 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSMB4... {November 9, 2007 1:19:22 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMB4 image.jpg {November 9, 2007 1:21:21 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:21:37 AM PST}
- CREATED: Created new protein page: PSMB4 {November 9, 2007 1:21:44 AM PST}
- INFO: Beginning work on PSMD10... {November 9, 2007 1:21:44 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PSMD10 image.jpg {November 9, 2007 1:23:14 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:23:25 AM PST}
- CREATED: Created new protein page: PSMD10 {November 9, 2007 1:23:34 AM PST}
- INFO: Beginning work on PSME2... {November 9, 2007 1:23:34 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:24:18 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
| HGNCid = 9569
| Symbol = PSME2
| AltSymbols =; PA28B; PA28beta; REGbeta
| OMIM = 602161
| ECnumber =
| Homologene = 86889
| MGIid =
| GeneAtlas_image1 = PBB_GE_PSME2_201762_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008538 |text = proteasome activator activity}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0008537 |text = proteasome activator complex}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5721
| Hs_Ensembl = ENSG00000100911
| Hs_RefseqProtein = NP_002809
| Hs_RefseqmRNA = NM_002818
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 23682449
| Hs_GenLoc_end = 23686270
| Hs_Uniprot = Q9UL46
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)''', also known as '''PSME2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.<ref>{{cite web | title = Entrez Gene: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5721| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Sijts A, Sun Y, Janek K, ''et al.'' |title=The role of the proteasome activator PA28 in MHC class I antigen processing. |journal=Mol. Immunol. |volume=39 |issue= 3-4 |pages= 165-9 |year= 2002 |pmid= 12200048 |doi= }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTAFR... {November 9, 2007 1:24:18 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:25:10 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Platelet-activating factor receptor
| HGNCid = 9582
| Symbol = PTAFR
| AltSymbols =; PAFR
| OMIM = 173393
| ECnumber =
| Homologene = 20260
| MGIid = 106066
| GeneAtlas_image1 = PBB_GE_PTAFR_206278_at_tn.png
| GeneAtlas_image2 = PBB_GE_PTAFR_211661_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004992 |text = platelet activating factor receptor activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001816 |text = cytokine production}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0048015 |text = phosphoinositide-mediated signaling}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5724
| Hs_Ensembl = ENSG00000169403
| Hs_RefseqProtein = NP_000943
| Hs_RefseqmRNA = NM_000952
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 28346264
| Hs_GenLoc_end = 28392971
| Hs_Uniprot = P25105
| Mm_EntrezGene = 19204
| Mm_Ensembl = ENSMUSG00000056529
| Mm_RefseqmRNA = XM_357441
| Mm_RefseqProtein = XP_357441
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 131836299
| Mm_GenLoc_end = 131852935
| Mm_Uniprot = Q62035
}}
}}
'''Platelet-activating factor receptor''', also known as '''PTAFR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = PTAFR shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: PTAFR platelet-activating factor receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5724| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shukla SD |title=Platelet-activating factor receptor and signal transduction mechanisms. |journal=FASEB J. |volume=6 |issue= 6 |pages= 2296-301 |year= 1992 |pmid= 1312046 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RHCE... {November 9, 2007 1:25:10 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:26:25 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Rh blood group, CcEe antigens
| HGNCid = 10008
| Symbol = RHCE
| AltSymbols =; RHC; CD240CE; MGC103977; RH; RH30A; RHE; RHIXB; RHPI; Rh4; RhIVb(J); RhVI; RhVIII; CD240D; DIIIc; RH30; RHCED; RHDVA(TT); RHDel; RHPII; RHXIII; RhDCw; RhII; RhK562-II; RhPI
| OMIM = 111700
| ECnumber =
| Homologene = 7918
| MGIid = 1202882
| GeneAtlas_image1 = PBB_GE_RHCE_215819_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RHCE_216317_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_RHCE_210429_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6006
| Hs_Ensembl = ENSG00000188672
| Hs_RefseqProtein = XP_001130486
| Hs_RefseqmRNA = XM_001130486
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 25561328
| Hs_GenLoc_end = 25629270
| Hs_Uniprot = P18577
| Mm_EntrezGene = 19746
| Mm_Ensembl = ENSMUSG00000028825
| Mm_RefseqmRNA = NM_011270
| Mm_RefseqProtein = NP_035400
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 134136660
| Mm_GenLoc_end = 134168248
| Mm_Uniprot =
}}
}}
'''Rh blood group, CcEe antigens''', also known as '''RHCE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Alternative splicing of this gene results in four transcript variants encoding four different isoforms.<ref>{{cite web | title = Entrez Gene: RHCE Rh blood group, CcEe antigens| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6006| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Agre P, Cartron JP |title=Molecular biology of the Rh antigens. |journal=Blood |volume=78 |issue= 3 |pages= 551-63 |year= 1991 |pmid= 1907207 |doi= }}
*{{cite journal | author=Avent ND, Reid ME |title=The Rh blood group system: a review. |journal=Blood |volume=95 |issue= 2 |pages= 375-87 |year= 2000 |pmid= 10627438 |doi= }}
*{{cite journal | author=Flegel WA, Wagner FF |title=Molecular genetics of RH. |journal=Vox Sang. |volume=78 Suppl 2 |issue= |pages= 109-15 |year= 2000 |pmid= 10938938 |doi= }}
*{{cite journal | author=Wagner FF, Flegel WA |title=Review: the molecular basis of the Rh blood group phenotypes. |journal=Immunohematology / American Red Cross |volume=20 |issue= 1 |pages= 23-36 |year= 2004 |pmid= 15373666 |doi= }}
*{{cite journal | author=Callebaut I, Dulin F, Bertrand O, ''et al.'' |title=Hydrophobic cluster analysis and modeling of the human Rh protein three-dimensional structures. |journal=Transfusion clinique et biologique : journal de la Société française de transfusion sanguine |volume=13 |issue= 1-2 |pages= 70-84 |year= 2006 |pmid= 16584906 |doi= 10.1016/j.tracli.2006.02.001 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RPSA... {November 9, 2007 1:11:29 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:11:52 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribosomal protein SA
| HGNCid = 6502
| Symbol = RPSA
| AltSymbols =; 37LRP; 67LR; LAMBR; LAMR1; LRP; p40
| OMIM = 150370
| ECnumber =
| Homologene = 68249
| MGIid = 105381
| Function = {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}} {{GNF_GO|id=GO:0005055 |text = laminin receptor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005843 |text = cytosolic small ribosomal subunit (sensu Eukaryota)}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0015935 |text = small ribosomal subunit}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3921
| Hs_Ensembl =
| Hs_RefseqProtein = NP_001012321
| Hs_RefseqmRNA = NM_001012321
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 16785
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011029
| Mm_RefseqProtein = NP_035159
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ribosomal protein SA''', also known as '''RPSA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.<ref>{{cite web | title = Entrez Gene: RPSA ribosomal protein SA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3921| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Belkin AM, Stepp MA |title=Integrins as receptors for laminins. |journal=Microsc. Res. Tech. |volume=51 |issue= 3 |pages= 280-301 |year= 2000 |pmid= 11054877 |doi= 10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on S100A7... {November 9, 2007 1:26:25 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein S100A7 image.jpg {November 9, 2007 1:26:56 AM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 1:27:08 AM PST}
- CREATED: Created new protein page: S100A7 {November 9, 2007 1:27:15 AM PST}
- INFO: Beginning work on SFPQ... {November 9, 2007 1:27:57 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:29:14 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
| HGNCid = 10774
| Symbol = SFPQ
| AltSymbols =; PSF; POMP100
| OMIM = 605199
| ECnumber =
| Homologene = 3714
| MGIid = 1918764
| GeneAtlas_image1 = PBB_GE_SFPQ_201586_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFPQ_201585_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SFPQ_214016_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006310 |text = DNA recombination}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6421
| Hs_Ensembl = ENSG00000116560
| Hs_RefseqProtein = NP_005057
| Hs_RefseqmRNA = NM_005066
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 35414571
| Hs_GenLoc_end = 35431336
| Hs_Uniprot = P23246
| Mm_EntrezGene = 71514
| Mm_Ensembl = ENSMUSG00000028820
| Mm_RefseqmRNA = XM_981759
| Mm_RefseqProtein = XP_986853
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 126523639
| Mm_GenLoc_end = 126533100
| Mm_Uniprot = Q3TZL2
}}
}}
'''Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)''', also known as '''SFPQ''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Shav-Tal Y, Zipori D |title=PSF and p54(nrb)/NonO--multi-functional nuclear proteins. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 109-14 |year= 2002 |pmid= 12417296 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on STS... {November 9, 2007 1:04:58 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein STS image.jpg {November 9, 2007 1:06:24 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:06:42 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_STS_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p49.
| PDB = {{PDB2|1p49}}
| Name = Steroid sulfatase (microsomal), arylsulfatase C, isozyme S
| HGNCid = 11425
| Symbol = STS
| AltSymbols =; ARSC; ARSC1; ASC; ES; SSDD
| OMIM = 308100
| ECnumber =
| Homologene = 47918
| MGIid =
| GeneAtlas_image1 = PBB_GE_STS_203767_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_STS_203768_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STS_203769_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004773 |text = steryl-sulfatase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006706 |text = steroid catabolic process}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 412
| Hs_Ensembl = ENSG00000101846
| Hs_RefseqProtein = NP_000342
| Hs_RefseqmRNA = NM_000351
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 7147497
| Hs_GenLoc_end = 7282851
| Hs_Uniprot = P08842
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Steroid sulfatase (microsomal), arylsulfatase C, isozyme S''', also known as '''STS''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI).<ref>{{cite web | title = Entrez Gene: STS steroid sulfatase (microsomal), arylsulfatase C, isozyme S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=412| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Elias PM, Crumrine D, Rassner U, ''et al.'' |title=Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. |journal=J. Invest. Dermatol. |volume=122 |issue= 2 |pages= 314-9 |year= 2004 |pmid= 15009711 |doi= 10.1046/j.1523-1747.2003.22258.x }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on WWOX... {November 9, 2007 1:29:14 AM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein WWOX image.jpg {November 9, 2007 1:29:49 AM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 1:30:36 AM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_WWOX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wmv.
| PDB = {{PDB2|1wmv}}
| Name = WW domain containing oxidoreductase
| HGNCid = 12799
| Symbol = WWOX
| AltSymbols =; FRA16D; D16S432E; FOR; HHCMA56; PRO0128; WOX1; WWOX v8
| OMIM = 605131
| ECnumber =
| Homologene = 56334
| MGIid = 1931237
| GeneAtlas_image1 = PBB_GE_WWOX_221147_x_at_tn.png
| Function = {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}} {{GNF_GO|id=GO:0050662 |text = coenzyme binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 51741
| Hs_Ensembl = ENSG00000186153
| Hs_RefseqProtein = NP_057457
| Hs_RefseqmRNA = NM_016373
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 76691177
| Hs_GenLoc_end = 77803532
| Hs_Uniprot =
| Mm_EntrezGene = 80707
| Mm_Ensembl = ENSMUSG00000004637
| Mm_RefseqmRNA = NM_019573
| Mm_RefseqProtein = NP_062519
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 117325749
| Mm_GenLoc_end = 118237803
| Mm_Uniprot = Q91WL8
}}
}}
'''WW domain containing oxidoreductase''', also known as '''WWOX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.<ref>{{cite web | title = Entrez Gene: WWOX WW domain containing oxidoreductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51741| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ramos D, Aldaz CM |title=WWOX, a chromosomal fragile site gene and its role in cancer. |journal=Adv. Exp. Med. Biol. |volume=587 |issue= |pages= 149-59 |year= 2007 |pmid= 17163164 |doi= }}
}}
{{refend}}
{{protein-stub}}
end log.
