The William H. Wells House is a two-and-one-half-story Romanesque Revival mansion, built of coursed, rock-face stone. The house is built on an irregular plan with an asymmetrical, picturesque composition. The entrance is within a projection, and a turret with a concave conical roof at one corner sits at one corner of the house. Other bays project randomly from the main structure. A 11⁄2-story carriage house in red brick and clapboard was built at the rear of the house in 1891.
The house is significant as an outstanding example of Romanesque residential architecture in Detroit and for its association with architect William Henry Miller.