The area known today as Greektown was first settled in the 1830s by German immigrants, who created a primarily residential neighborhood in the area. However, in the earliest years of the 20th century, most of the German residents began moving from the neighborhood into areas further from downtown. As the Germans left the area, new Greek immigrants moved in, spurred by Theodore Gerasimos, the first documented Greek immigrant in Detroit. The newly arrived Greeks established businesses in the neighborhood.
By the 1920s, the area was becoming primarily commercial rather than residential, and the Greek residents began moving out; however, the restaurants, stores, and coffeehouses they established remained. The next thirty years brought a melange of immigrants to the few residential spaces left in the neighborhood. Redevelopment in the 1960s led to the neighborhood becoming more commercialized to provide space for municipal buildings and parking.
Realizing the culturally significant neighborhood was at risk, Detroit's Greek leaders banded together. With the help of the Mayor's office, the streetscape and building exteriors were improved, and additional street lighting was installed. The neighborhood threw a Greek festival in 1966, timed to coincide with Fourth of July celebrations. The festival was a success, and was continued for years until turnout grew too large. By that time, Greektown was firmly established in Detroit. The Greektown Historic District was listed on the National Register of Historic Places in 1982.
As of June 2012[update] only three full-fledged Greek restaurants remain in Greektown. The neighborhood is a popular restaurant and entertainment district, having many restaurants that serve authentic Greek cuisine, as well as one of the city's three casinos, Greektown Casino. Certain buildings on Monroe Street are themed to resemble the Parthenon, Pegasus, and other forms of Greek architecture. Greek music is also played on Monroe Street throughout the day. Well known restaurants include The New Parthenon, The Golden Fleece, Laikon Cafe, Cyprus Taverna, Pegasus Taverna, Pizza Papalis, and Fishbone's Rhythm Kitchen Cafe. The Detroit People Mover has a station at the Greektown Casino on Beaubien Street between Monroe Street and Lafayette Boulevard.
In the American cable TV series Low Winter Sun (2013), the Detroit Police precinct is located four blocks from Greektown (this is reiterated thrice in season 1, episode 4), and Maya and Damon "kick up" tributes from her bar and from their drug and prostitution earnings to Skelos, Greektown's main crime lord. Seeking to gain independence from Skelos, Damon opens a blind pig outside of Greektown, where he kicks up to Reverend Lowdown (season 1, episodes 3 and 4).