Filip Swirski: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Next edit →
Content deleted Content added
VisualWikitext
←Created page with ' {{Shortdesc|American cardiovascular scientist}} {{Infobox scientist | name = Filip Swirski | image = thumb | image_size = | citizenship = United States | nationality = Polish, Canadian, US | fields = Cardiology, immunology | workplaces = Icahn School of Medicine at Mount Sinai, Harvard Medical School, Massachusetts General Hospital | alma_mater...'
(No difference)

Revision as of 20:25, 22 March 2024


Filip Swirski
File:FilipSwirskiLandscape.jpg
NationalityPolish, Canadian, US
CitizenshipUnited States
Alma materMcMaster University, Harvard Medical School
Known forLinking atherosclerosis with blood monocytosis, identifying how sleep interruption accelerates atherosclerosis and neutral drift, demonstrating IL-3 role in protecting against Alzheimer's disease
AwardsOutstanding Investigator Award, NHLBI; Established Investigator Award, American Heart Association
Scientific career
FieldsCardiology, immunology
InstitutionsIcahn School of Medicine at Mount Sinai, Harvard Medical School, Massachusetts General Hospital
WebsiteSwirski Lab

Filip Swirski is a Polish-Canadian-American scientist and educator serving as the Arthur and Janet C. Ross Professor of Medicine, Cardiology and Professor of Radiology at the Icahn School of Medicine at Mount Sinai and is the Director of the Cardiovascular Research Institute. He is also a member of the Biomedical Engineering Innovation (BMEI), the Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM), and The Friedman Brain Institutes (FBI) at Mount Sinai. His research partly focuses on innate and inflammatory mechanisms in cardiovascular disease. He is known for his work in cardioimmunology and notably for linking atherosclerosis with blood monocytosis.[1][2][3]

Education and career

Swirski earned his Bachelor of Arts and Science specializing in biochemistry and a Ph.D. (FOCUS ON) in immunology at McMaster University, Hamilton, Canada. He received an honorary MS from Harvard Medical School in 2020 for accomplishing a full professorship. He was a professor at the Center for Systems Biology at Massachusetts General Hospital and at Harvard Medical School.[1][2][4]

Research and scientific contributions

Swirski focuses on understanding how leukocytes shape and are shaped by inflammation. His research uses in vivo models of acute and chronic inflammation relevant to cardiovascular, neurodegenerative, infectious, and metabolic diseases.[5] His writings reflect translational and fundamental cardiovascular and neurodegenerative science research, including cell development, mind-marrow communication, and function.[6][7]

Novel findings

Monocytes and macrophages

  • Swirski described that increased blood monocyte levels, otherwise known as monocytosis, develop in response to hypercholesterolemia[8] and is progressive and proportional to disease severity.[9]

Lifestyle and brain-body communication

  • Swirski explores how cardiovascular health is affected by diet, sleep, exercise, and other lifestyle patterns. He showed that sleep limits monocyte production, thereby protecting against atherosclerosis.[11][12]
  • Showed that sleep fragmentation increases atherogenesis in a mouse model and demonstrated that sleep disruption increases myelopoiesis in the bone marrow, leading to monocytosis and larger atherosclerotic lesions. The results yielded that the marrow contains a pre-neutrophil that regulates monocyte production via hypocretin-dependent CSF-1. Hypocretin, a wake-promoting hormone in the hypothalamus, communicates with bone marrow and regulates leukocyte production. This demonstrates a brain-marrow axis involving a secreted neuropeptide.[13]
  • He demonstrated that sleep interruption increases the rate of hematopoiesis in the bone marrow, which accelerates atherosclerosis and neutral drift.[14]
  • Showed that IL-3 is a crucial communicator between glial cells (microglia) located throughout the brain and spinal cord, and astrocytes. Using mouse models of Alzheimer’s Disease (AD), data showed that IL-3 protects against AD by programming microglia.[15]
  • Under psychological stress, neurons from different brain regions control the migration of immune cells in the body.[16] Mice under stress were more prone to higher inflammation and death in response to infection with influenza and SARS-CoV-2.[17]
  • Fasting in mice prompts monocytes to re-enter the bone marrow, which increases their lifespan. This process is mediated by the hypothalamic-pituitary-adrenal axis (HPA) (Janssen et al. Immunity 2023).[citation needed]
    • Upon re-feeding, distinct monocytes mobilize back to the blood, altering the host's response to infection. The underlying study showed the body can limit energy expenditure when nutrition is scarce. Without it, the body slows down metabolic expenditure, limiting production and preserving—and thus extending—the lifespan of already-made, short-lived monocytes.[18]

Immunometabiolic communication

  • Swirski identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron.[19][20]
  • Identified a population of intraepithelial T cells that are strategically positioned in the gut that modulate systemic dietary metabolism. Without these, mice were metabolically hyperactive, and resisted the development of obesity, hypertension, diabetes, and hypercholesterolemia/atherosclerosis.[21]
  • Showed that cholesterol sensors called Liver X Receptors were important in developing and functioning T cells in the thymus, the lymphoid gland where T cells are produced.[22]

Influence of hematopoiesis growth factors

  • Swirski showed the Influence of growth factors in disease, where he described a GM-CSF-producing B cell that protects against sepsis and pneumonia.[23]
  • Demonstrated that the growth factor interleukin 3 (IL-3) aggravates sepsis by eliciting a cytokine storm, heightening inflammation leading to death.[24]

Research grants

As of 2022, Swirski has received 26 research grants from the National Institutes of Health and is the principal investigator on three ongoing grants:[26] Macrophages in homeostasis and cardiovascular disease,[27] Stress and atherosclerotic plaque macrophages — A systems biology approach,[28] and Hematopoiesis in cardiovascular disease.[29]

Honors and awards

Partial list:[7]

  • Clarivate Highly Cited Investigators[30]
  • Outstanding Investigator Award from the NHLBI (2016-2022)
  • Jeffrey M. Hoeg Award from the American Heart Association (2017)
  • Martin Prize for Fundamental Research Howard M. Goodman Fellowship (2016)

Publications

As of 2022, Swirski is credited with 31,791 citations and has an h-index of 95.[31] His most cited contributions to date are on heart infraction, ventricular remodeling, inflammation, stem cell niche, hematopoiesis and hematopoietic stem cells.[32] Between 2018 and 2019, articles reportedly focused most on inflammation (43.72%), bone marrow (17.21%) and immune system (17.21%).[33]

Articles

Five most-cited peer-reviewed publications as of 2022 include:[34]

  • The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions M Nahrendorf, FK Swirski, E Aikawa, L Stangenberg, T Wurdinger, ...The Journal of experimental medicine 204 (12), 3037-3047 PMID:18025128[35] Cited by 2257
  • Identification of splenic reservoir monocytes and their deployment to inflammatory sites FK Swirski, M Nahrendorf, M Etzrodt, M Wildgruber, V Cortez-Retamozo, ...Science 325 (5940), 612-616 PMID: 19644120[36] Cited by 2227
  • Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata FK Swirski, P Libby, E Aikawa, P Alcaide, FW Luscinskas, R Weissleder, ...The Journal of clinical investigation 117 (1), 195-205 PMID: 19644120[37] Cited by 1313
  • Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure FK Swirski, M Nahrendorf Science 339 (6116), 161-166 PMID: 23307733[38] Cited by 951
  • Myocardial infarction accelerates atherosclerosi P Dutta, G Courties, Y Wei, F Leuschner, R Gorbatov, CS Robbins Nature 487 (7407), 325-329 PMID: 22763456[39] Cited by 946

Book chapters

  • Swirski, F.K., Nahrendorf, M. and Libby, P. (2017). Mechanisms of Myeloid Cell Modulation of Atherosclerosis. In Myeloid Cells in Health and Disease, S. Gordon (Ed.).[40]
  • Pittet, M.J., Nahrendorf, M. and Swirski, F.K. (2014), The journey from stem cell to macrophage. Ann. N.Y. Acad. Sci., 1319: 1-18.[41]
  • Monocyte subset dynamics in human atherosclerosis Recent Advances in Nanotechnology, Page: 71-83, 2011[42]

References

  1. ^ a b "ORCID". orcid.org. Retrieved 2022-08-15.
  2. ^ a b "STRIVE (Stress and Trauma: Impact on Cardiovascular Disease)". Stress. Retrieved August 15, 2022.
  3. ^ Swirski, Filip K.; Nahrendorf, Matthias. "Cardioimmunology: the immune system in cardiac homeostasis and disease". Nature Reviews. Immunology. 18 (12): 733–744. doi:10.1038/s41577-018-0065-8. ISSN 1474-1741. PMID 30228378.
  4. ^ Jansen, Jaclyn M. (2018-05-11). "Filip Swirski: Understanding How Inflammation Both Heals and Hurts the Heart". Circulation Research. 122 (10): 1334–1337. doi:10.1161/CIRCRESAHA.118.313204. ISSN 0009-7330.
  5. ^ Jansen, Jaclyn M. (2018-05-11). "Filip Swirski". Circulation Research. 122 (10): 1334–1337. doi:10.1161/CIRCRESAHA.118.313204.
  6. ^ "Filip Swirski, PhD, MGH Research Scholar Profile". Massachusetts General Hospital. Retrieved 2022-08-15.
  7. ^ a b "Filip Swirski". Cure Alzheimer's Fund. Retrieved 2022-08-15.
  8. ^ Swirski, Filip K.; Libby, Peter; Aikawa, Elena; Alcaide, Pilar; Luscinskas, F. William; Weissleder, Ralph; Pittet, Mikael J. (2007-01-02). "Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata". The Journal of Clinical Investigation. 117 (1): 195–205. doi:10.1172/JCI29950. ISSN 0021-9738. PMID 17200719.
  9. ^ rupress.org https://rupress.org/jem/article/219/11/e20220081/213487/Sleep-exerts-lasting-effects-on-hematopoietic-stem. Retrieved 2024-03-18. {{cite web}}: Missing or empty |title= (help)
  10. ^ Swirski, Filip K.; Nahrendorf, Matthias; Etzrodt, Martin; Wildgruber, Moritz; Cortez-Retamozo, Virna; Panizzi, Peter; Figueiredo, Jose-Luiz; Kohler, Rainer H.; Chudnovskiy, Aleksey; Waterman, Peter; Aikawa, Elena; Mempel, Thorsten R.; Libby, Peter; Weissleder, Ralph; Pittet, Mikael J. (2009-07-31). "Identification of splenic reservoir monocytes and their deployment to inflammatory sites". Science (New York, N.Y.). 325 (5940): 612–616. doi:10.1126/science.1175202. ISSN 1095-9203. PMC 2803111. PMID 19644120.
  11. ^ "Medical research: Sufficient sleep reduces atherosclerosis risk in mice | Nature | Nature Portfolio". www.natureasia.com. Retrieved 2022-08-15.
  12. ^ "Lifestyle, cardiovascular health, and the brain". World Wide Neuroscience. Retrieved August 15, 2022.
  13. ^ McAlpine, Cameron S.; Kiss, Máté G.; Rattik, Sara; He, Shun; Vassalli, Anne; Valet, Colin; Anzai, Atsushi; Chan, Christopher T.; Mindur, John E.; Kahles, Florian; Poller, Wolfram C.; Frodermann, Vanessa; Fenn, Ashley M.; Gregory, Annemijn F.; Halle, Lennard (2019-02). "Sleep modulates haematopoiesis and protects against atherosclerosis". Nature. 566 (7744): 383–387. doi:10.1038/s41586-019-0948-2. ISSN 1476-4687. PMC 6442744. PMID 30760925. {{cite journal}}: Check date values in: |date= (help)
  14. ^ rupress.org https://rupress.org/jem/article/219/11/e20220081/213487/Sleep-exerts-lasting-effects-on-hematopoietic-stem. Retrieved 2024-03-18. {{cite web}}: Missing or empty |title= (help)
  15. ^ McAlpine, Cameron S.; Park, Joseph; Griciuc, Ana; Kim, Eunhee; Choi, Se Hoon; Iwamoto, Yoshiko; Kiss, Máté G.; Christie, Kathleen A.; Vinegoni, Claudio; Poller, Wolfram C.; Mindur, John E.; Chan, Christopher T.; He, Shun; Janssen, Henrike; Wong, Lai Ping (2021-07). "Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease". Nature. 595 (7869): 701–706. doi:10.1038/s41586-021-03734-6. ISSN 1476-4687. PMC 8934148. PMID 34262178. {{cite journal}}: Check date values in: |date= (help)
  16. ^ Poller, Wolfram C.; Downey, Jeffrey; Mooslechner, Agnes A.; Khan, Nargis; Li, Long; Chan, Christopher T.; McAlpine, Cameron S.; Xu, Chunliang; Kahles, Florian; He, Shun; Janssen, Henrike; Mindur, John E.; Singh, Sumnima; Kiss, Máté G.; Alonso-Herranz, Laura (2022-07). "Brain motor and fear circuits regulate leukocytes during acute stress". Nature. 607 (7919): 578–584. doi:10.1038/s41586-022-04890-z. ISSN 1476-4687. {{cite journal}}: Check date values in: |date= (help)
  17. ^ "Stress may be detrimental to fighting off infections • Earth.com". www.earth.com. Retrieved 2022-08-15.
  18. ^ Janssen, Henrike; Kahles, Florian; Liu, Dan; Downey, Jeffrey; Koekkoek, Laura L.; Roudko, Vladimir; D'Souza, Darwin; McAlpine, Cameron S.; Halle, Lennard; Poller, Wolfram C.; Chan, Christopher T.; He, Shun; Mindur, John E.; Kiss, Máté G.; Singh, Sumnima (2023-04-11). "Monocytes re-enter the bone marrow during fasting and alter the host response to infection". Immunity. 56 (4): 783–796.e7. doi:10.1016/j.immuni.2023.01.024. ISSN 1097-4180. PMID 36827982.
  19. ^ Robbins, Clinton S.; Chudnovskiy, Aleksey; Rauch, Philipp J.; Figueiredo, Jose-Luiz; Iwamoto, Yoshiko; Gorbatov, Rostic; Etzrodt, Martin; Weber, Georg F.; Ueno, Takuya; van Rooijen, Nico; Mulligan-Kehoe, Mary Jo; Libby, Peter; Nahrendorf, Matthias; Pittet, Mikael J.; Weissleder, Ralph (2012-01-17). "Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions". Circulation. 125 (2): 364–374. doi:10.1161/CIRCULATIONAHA.111.061986. ISSN 1524-4539. PMC 3263762. PMID 22144566.
  20. ^ Theurl, Igor; Hilgendorf, Ingo; Nairz, Manfred; Tymoszuk, Piotr; Haschka, David; Asshoff, Malte; He, Shun; Gerhardt, Louisa M. S.; Holderried, Tobias A. W.; Seifert, Markus; Sopper, Sieghart; Fenn, Ashley M.; Anzai, Atsushi; Rattik, Sara; McAlpine, Cameron. "On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver". Nature Medicine. 22 (8): 945–951. doi:10.1038/nm.4146. ISSN 1546-170X. PMC 4957133. PMID 27428900.
  21. ^ He, Shun; Kahles, Florian; Rattik, Sara; Nairz, Manfred; McAlpine, Cameron S.; Anzai, Atsushi; Selgrade, Daniel; Fenn, Ashley M.; Chan, Christopher T.; Mindur, John E.; Valet, Colin; Poller, Wolfram C.; Halle, Lennard; Rotllan, Noemi; Iwamoto, Yoshiko. "Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease". Nature. 566 (7742): 115–119. doi:10.1038/s41586-018-0849-9. ISSN 1476-4687. PMC 6367023. PMID 30700910.
  22. ^ rupress.org https://rupress.org/jem/article/217/10/e20200318/151978/Liver-X-receptors-are-required-for-thymic. Retrieved 2024-03-18. {{cite web}}: Missing or empty |title= (help)
  23. ^ "Innate Response Activator B Cells Protect Against Microbial Sepsis". Science. January 12 2012. Retrieved March 18 2024. {{cite web}}: Check date values in: |access-date= and |date= (help)
  24. ^ "Innate Response Activator B Cells Protect Against Microbial Sepsis". Journal of Experimental Medicine. Retrieved 2024-03-18.
  25. ^ rupress.org https://rupress.org/jem/article/216/2/369/120325/Self-reactive-CD4-IL-3-T-cells-amplify-autoimmune. Retrieved 2024-03-18. {{cite web}}: Missing or empty |title= (help)
  26. ^ "Author search". Grantome.com. Retrieved August 15, 2022.
  27. ^ "Macrophages in homeostasis and cardiovascular disease". Grantome.com. Retrieved August 15, 2022.
  28. ^ Fayad, Zahi. "Stress and Atherosclerotic Plaque Macrophages - A Systems Biology Approach". {{cite journal}}: Cite journal requires |journal= (help)
  29. ^ Poller, Wolfram C.; Nahrendorf, Matthias; Swirski, Filip K. (2020-04-10). "Hematopoiesis and Cardiovascular Disease". Circulation Research. 126 (8): 1061–1085. doi:10.1161/CIRCRESAHA.120.315895. PMC 7153537. PMID 32271679.{{cite journal}}: CS1 maint: PMC format (link)
  30. ^ "Web of Science". www.webofscience.com. Retrieved 2024-03-18.
  31. ^ "Filip K. Swirski". scholar.google.com. Retrieved 2022-08-16.
  32. ^ "Scopus preview - Swirski, Filip K. - Author details - Scopus". www.scopus.com. Retrieved 2022-08-15.
  33. ^ "Filip K. Swirski: H-index & Awards - Academic Profile". Research.com. Retrieved 2022-08-15.
  34. ^ "Filip K. Swirski". scholar.google.com. Retrieved 2022-08-15.
  35. ^ Nahrendorf, Matthias; Swirski, Filip K.; Aikawa, Elena; Stangenberg, Lars; Wurdinger, Thomas; Figueiredo, Jose-Luiz; Libby, Peter; Weissleder, Ralph; Pittet, Mikael J. (2007-11-26). "The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions". The Journal of Experimental Medicine. 204 (12): 3037–3047. doi:10.1084/jem.20070885. ISSN 1540-9538. PMC 2118517. PMID 18025128.
  36. ^ Swirski, Filip K.; Nahrendorf, Matthias; Etzrodt, Martin; Wildgruber, Moritz; Cortez-Retamozo, Virna; Panizzi, Peter; Figueiredo, Jose-Luiz; Kohler, Rainer H.; Chudnovskiy, Aleksey; Waterman, Peter; Aikawa, Elena; Mempel, Thorsten R.; Libby, Peter; Weissleder, Ralph; Pittet, Mikael J. (2009-07-31). "Identification of splenic reservoir monocytes and their deployment to inflammatory sites". Science (New York, N.Y.). 325 (5940): 612–616. doi:10.1126/science.1175202. ISSN 1095-9203. PMC 2803111. PMID 19644120.
  37. ^ Swirski, Filip K.; Nahrendorf, Matthias; Etzrodt, Martin; Wildgruber, Moritz; Cortez-Retamozo, Virna; Panizzi, Peter; Figueiredo, Jose-Luiz; Kohler, Rainer H.; Chudnovskiy, Aleksey; Waterman, Peter; Aikawa, Elena; Mempel, Thorsten R.; Libby, Peter; Weissleder, Ralph; Pittet, Mikael J. (2009-07-31). "Identification of splenic reservoir monocytes and their deployment to inflammatory sites". Science (New York, N.Y.). 325 (5940): 612–616. doi:10.1126/science.1175202. ISSN 1095-9203. PMC 2803111. PMID 19644120.
  38. ^ Swirski, Filip K.; Nahrendorf, Matthias (2013-01-11). "Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure". Science (New York, N.Y.). 339 (6116): 161–166. doi:10.1126/science.1230719. ISSN 1095-9203. PMC 3891792. PMID 23307733.
  39. ^ Dutta, Partha; Courties, Gabriel; Wei, Ying; Leuschner, Florian; Gorbatov, Rostic; Robbins, Clinton S.; Iwamoto, Yoshiko; Thompson, Brian; Carlson, Alicia L.; Heidt, Timo; Majmudar, Maulik D.; Lasitschka, Felix; Etzrodt, Martin; Waterman, Peter; Waring, Michael T. (2012-07-19). "Myocardial infarction accelerates atherosclerosis". Nature. 487 (7407): 325–329. doi:10.1038/nature11260. ISSN 1476-4687. PMC 3401326. PMID 22763456.
  40. ^ Swirski, Filip K.; Nahrendorf, Matthias; Libby, Peter (2017-01-12), Gordon, Siamon (ed.), "Mechanisms of Myeloid Cell Modulation of Atherosclerosis", Myeloid Cells in Health and Disease, Washington, DC, USA: ASM Press, pp. 813–824, doi:10.1128/9781555819194.ch47, ISBN 978-1-68367-066-7, retrieved 2022-08-16
  41. ^ Pittet, Mikael J.; Nahrendorf, Matthias; Swirski, Filip K. "The journey from stem cell to macrophage: Macrophage development". Annals of the New York Academy of Sciences. 1319 (1): 1–18. doi:10.1111/nyas.12393. PMC 4074243. PMID 24673186.{{cite journal}}: CS1 maint: PMC format (link)
  42. ^ "Scopus preview - Scopus - Welcome to Scopus". www.scopus.com. Retrieved 2022-08-16.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Filip_Swirski&oldid=1215048047"