Cyclin E2

From Wikipedia, the free encyclopedia
  (Redirected from CCNE2)
Jump to: navigation, search
cyclin E2
Symbol CCNE2
Entrez 9134
HUGO 1590
OMIM 603775
RefSeq NM_057749
UniProt O96020
Other data
Locus Chr. 8 q22.1

Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]


  1. ^ a b Gudas, Jean M.; Payton, Marc; Thukral, Sushil; Chen, Eddy; Bass, Michael; Robinson, Murray O.; Coats, Steve (1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology 19 (1): 612–22. PMC 83919. PMID 9858585.  edit