The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.
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^Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene9 (10): 3037–41. PMID8084611.CS1 maint: Date and year (link)
^Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID11313931.CS1 maint: Date and year (link)
Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995). "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res.55 (18): 3992–5. PMID7664269.
Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL et al. (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res.55 (6): 1199–205. PMID7882308.
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Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C et al. (1999). "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics56 (1): 90–7. doi:10.1006/geno.1998.5676. PMID10036189.
Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID11313931.
Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell Proteomics6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID17192257.Vancouver style error (help)