Cyclin-dependent kinase 7

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Cyclin-dependent kinase 7
Protein CDK7 PDB 1ua2.png
PDB rendering based on 1ua2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CDK7 ; CAK1; CDKN7; HCAK; MO15; STK1; p39MO15
External IDs OMIM601955 MGI102956 HomoloGene1363 ChEMBL: 3055 GeneCards: CDK7 Gene
EC number 2.7.11.22, 2.7.11.23
RNA expression pattern
PBB GE CDK7 211297 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1022 12572
Ensembl ENSG00000134058 ENSMUSG00000069089
UniProt P50613 Q03147
RefSeq (mRNA) NM_001799 NM_009874
RefSeq (protein) NP_001790 NP_034004
Location (UCSC) Chr 5:
68.53 – 68.57 Mb
Chr 13:
100.7 – 100.73 Mb
PubMed search [1] [2]

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.[1]

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.[2]

Interactions[edit]

Cyclin-dependent kinase 7 has been shown to interact with XPB,[3][4][5] Cyclin H,[5][6][7] P53,[8][9] Androgen receptor,[10] GTF2H1,[4][5][11] MNAT1[5][12] and SUPT5H.[7]

See also[edit]

References[edit]

  1. ^ Fisher RP, Morgan DO (September 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase". Cell 78 (4): 713–24. doi:10.1016/0092-8674(94)90535-5. PMID 8069918. 
  2. ^ "Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)". 
  3. ^ Giglia-Mari, Giuseppina; Coin Frederic, Ranish Jeffrey A, Hoogstraten Deborah, Theil Arjan, Wijgers Nils, Jaspers Nicolaas G J, Raams Anja, Argentini Manuela, van der Spek P J, Botta Elena, Stefanini Miria, Egly Jean-Marc, Aebersold Ruedi, Hoeijmakers Jan H J, Vermeulen Wim (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A". Nat. Genet. (United States) 36 (7): 714–9. doi:10.1038/ng1387. ISSN 1061-4036. PMID 15220921. 
  4. ^ a b Rossignol, M; Kolb-Cheynel I; Egly J M (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH". EMBO J. (ENGLAND) 16 (7): 1628–37. doi:10.1093/emboj/16.7.1628. ISSN 0261-4189. PMC 1169767. PMID 9130708. 
  5. ^ a b c d Yee, A; Nichols M A; Wu L; Hall F L; Kobayashi R; Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res. (UNITED STATES) 55 (24): 6058–62. ISSN 0008-5472. PMID 8521393. 
  6. ^ Mäkelä, T P; Tassan J P; Nigg E A; Frutiger S; Hughes G J; Weinberg R A (September 1994). "A cyclin associated with the CDK-activating kinase MO15". Nature (ENGLAND) 371 (6494): 254–7. doi:10.1038/371254a0. ISSN 0028-0836. PMID 8078587. 
  7. ^ a b Garber, M E; Mayall T P; Suess E M; Meisenhelder J; Thompson N E; Jones K A (September 2000). "CDK9 Autophosphorylation Regulates High-Affinity Binding of the Human Immunodeficiency Virus Type 1 Tat–P-TEFb Complex to TAR RNA". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6958–69. doi:10.1128/MCB.20.18.6958-6969.2000. ISSN 0270-7306. PMC 88771. PMID 10958691. 
  8. ^ Ko, L J; Shieh S Y; Chen X; Jayaraman L; Tamai K; Taya Y; Prives C; Pan Z Q (December 1997). "p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner". Mol. Cell. Biol. (UNITED STATES) 17 (12): 7220–9. ISSN 0270-7306. PMC 232579. PMID 9372954. 
  9. ^ Schneider, E; Montenarh M; Wagner P (November 1998). "Regulation of CAK kinase activity by p53". Oncogene (ENGLAND) 17 (21): 2733–41. doi:10.1038/sj.onc.1202504. ISSN 0950-9232. PMID 9840937. 
  10. ^ Lee, D K; Duan H O; Chang C (March 2000). "From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator". J. Biol. Chem. (UNITED STATES) 275 (13): 9308–13. doi:10.1074/jbc.275.13.9308. ISSN 0021-9258. PMID 10734072. 
  11. ^ Shiekhattar, R; Mermelstein F; Fisher R P; Drapkin R; Dynlacht B; Wessling H C; Morgan D O; Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature (ENGLAND) 374 (6519): 283–7. doi:10.1038/374283a0. ISSN 0028-0836. PMID 7533895. 
  12. ^ Talukder, Amjad H; Mishra Sandip K; Mandal Mahitosh; Balasenthil Seetharaman; Mehta Sonal; Sahin Aysegul A; Barnes Christopher J; Kumar Rakesh (March 2003). "MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions". J. Biol. Chem. (United States) 278 (13): 11676–85. doi:10.1074/jbc.M209570200. ISSN 0021-9258. PMID 12527756. 

Further reading[edit]

External links[edit]