CDC2L1

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Cyclin-dependent kinase 11B
Identifiers
Symbols CDK11B ; CDC2L1; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; PK58; p58; p58CDC2L1; p58CLK-1
External IDs OMIM176873 HomoloGene22416 ChEMBL: 5808 GeneCards: CDK11B Gene
EC number 2.7.11.22
Orthologs
Species Human Mouse
Entrez 984 12537
Ensembl ENSG00000008128 ENSMUSG00000029062
UniProt P21127 P24788
RefSeq (mRNA) NM_001787 NM_007661
RefSeq (protein) NP_277021 NP_031687
Location (UCSC) Chr 1:
1.57 – 1.59 Mb
Chr 4:
155.62 – 155.65 Mb
PubMed search [1] [2]

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.[1][2][3]

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.[3]

Interactions[edit]

CDC2L1 has been shown to interact with Cyclin D3.[4]

References[edit]

  1. ^ Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (Mar 1992). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066. 
  2. ^ Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (Sep 2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM". Biochem. Biophys. Res. Commun. 310 (1): 14–8. doi:10.1016/j.bbrc.2003.08.116. PMID 14511641. 
  3. ^ a b "Entrez Gene: CDC2L1 cell division cycle 2-like 1 (PITSLRE proteins)". 
  4. ^ Zhang, Songwen; Cai Mingmei; Zhang Si; Xu Songli; Chen She; Chen Xiaoning; Chen Chun; Gu Jianxin (Sep 2002). "Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3". J. Biol. Chem. (United States) 277 (38): 35314–22. doi:10.1074/jbc.M202179200. ISSN 0021-9258. PMID 12082095. 

Further reading[edit]