CDH4

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Cadherin 4, type 1, R-cadherin (retinal)
Identifiers
Symbols CDH4 ; CAD4; RCAD
External IDs OMIM603006 MGI99218 HomoloGene48044 GeneCards: CDH4 Gene
RNA expression pattern
PBB GE CDH4 206866 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1002 12561
Ensembl ENSG00000179242 ENSMUSG00000000305
UniProt P55283 P39038
RefSeq (mRNA) NM_001252338 NM_009867
RefSeq (protein) NP_001239267 NP_033997
Location (UCSC) Chr 20:
59.83 – 60.51 Mb
Chr 2:
179.44 – 179.9 Mb
PubMed search [1] [2]

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[1][2][3]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[3]


Interactions[edit]

Cadherin-4 has been shown to interact with:

References[edit]

  1. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  2. ^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. 
  3. ^ a b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)". 
  4. ^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo.". J Cell Biol 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566. 

Further reading[edit]

External links[edit]