CD29

Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
	; Rendering based on PDB 1K11.
Available structures
PDB	1K11, 1LHA, 3G9W
Identifiers
Symbols	ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB
External IDs	OMIM: 135630 MGI: 96610 HomoloGene: 22999 GeneCards: ITGB1 Gene
Gene Ontology
Molecular function	• glycoprotein binding; • fibronectin binding; • protease binding; • actin binding; • receptor activity; • integrin binding; • protein binding; • collagen binding; • protein kinase binding; • protein domain specific binding; • peptide binding; • identical protein binding; • laminin binding; • protein heterodimerization activity; • alpha-actinin binding;
Cellular component	• acrosomal vesicle; • ruffle; • basement membrane; • plasma membrane; • plasma membrane; • plasma membrane; • cell-cell junction; • adherens junction; • focal adhesion; • focal adhesion; • integrin complex; • cell surface; • intercalated disc; • integral to membrane; • synaptosome; • hemidesmosome; • neuromuscular junction; • cleavage furrow; • ruffle membrane; • alpha3-beta1 integrin complex; • alpha9-beta1 integrin complex; • sarcolemma; • melanosome; • membrane raft;
Biological process	• G1/S transition of mitotic cell cycle; • in utero embryonic development; • cell fate specification; • tissue homeostasis; • cell migration involved in sprouting angiogenesis; • cellular calcium ion homeostasis; • cellular defense response; • cell adhesion; • homophilic cell adhesion; • leukocyte cell-cell adhesion; • cell-matrix adhesion; • integrin-mediated signaling pathway; • multicellular organismal development; • axon guidance; • blood coagulation; • regulation of G-protein coupled receptor protein signaling pathway; • positive regulation of cell proliferation; • negative regulation of cell proliferation; • germ cell migration; • positive regulation of cell-substrate adhesion; • positive regulation of neuron projection development; • response to activity; • cell migration; • B cell differentiation; • positive regulation of cell migration; • negative regulation of cell projection organization; • response to nutrient levels; • protein transport within lipid bilayer; • cell-cell adhesion mediated by integrin; • cell junction assembly; • response to gonadotropin stimulus; • response to drug; • positive regulation of apoptosis; • positive regulation of MAPKKK cascade; • interspecies interaction between organisms; • sarcomere organization; • negative regulation of neuron differentiation; • positive regulation of neuron differentiation; • positive regulation of endocytosis; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of immune response; • leukocyte migration; • regulation of cell cycle; • cardiac muscle cell differentiation; • maternal process involved in female pregnancy; • tight junction assembly; • cellular response to mechanical stimulus; • cellular response to vitamin D; • cellular response to protein stimulus; • cellular response to ionizing radiation; • response to transforming growth factor beta stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

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Integrin beta-1 is a protein that in humans is encoded by the ITGB1 gene.^[1] CD29 is an integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin.

Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.^[2]

[edit] Interactions

CD29 has been shown to interact with TSPAN4,^[3] CD9,^[4]^[5] Filamin,^[6]^[7] FLNB,^[6] CD81,^[5]^[8] CD46,^[9] MAP4K4,^[10] FHL2,^[11] NME1,^[12] PKC alpha,^[13]^[14] YWHAB,^[15] ITGB1BP1,^[16]^[17] LGALS8^[18] and GNB2L1.^[13]^[19] A neutralizing antibody for CD29 is AIIB2.

[edit] References

^ Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (Jul 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Ann Hum Genet 53 (Pt 1): 15–22. doi:10.1111/j.1469-1809.1989.tb01118.x. PMID 2524991.
^ "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3688.
^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.
^ Radford, K J; Thorne R F, Hersey P (May. 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. (UNITED STATES) 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. ISSN 0006-291X. PMID 8630057.
^ ^a ^b Mazzocca, Antonio; Carloni Vinicio, Sciammetta Silvia, Cordella Claudia, Pantaleo Pietro, Caldini Anna, Gentilini Paolo, Pinzani Massimo (Sep. 2002). "Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration". J. Hepatol. (England) 37 (3): 322–30. doi:10.1016/S0168-8278(02)00175-7. ISSN 0168-8278. PMID 12175627.
^ ^a ^b van der Flier, Arjan; Kuikman Ingrid, Kramer Duco, Geerts Dirk, Kreft Maaike, Takafuta Toshiro, Shapiro Sandor S, Sonnenberg Arnoud (Jan. 2002). "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits". J. Cell Biol. (United States) 156 (2): 361–76. doi:10.1083/jcb.200103037. ISSN 0021-9525. PMC 2199218. PMID 11807098. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199218.
^ Loo, D T; Kanner S B, Aruffo A (Sep. 1998). "Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction". J. Biol. Chem. (UNITED STATES) 273 (36): 23304–12. doi:10.1074/jbc.273.36.23304. ISSN 0021-9258. PMID 9722563.
^ Serru, V; Le Naour F, Billard M, Azorsa D O, Lanza F, Boucheix C, Rubinstein E (May. 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. (ENGLAND) 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. ISSN 0264-6021. PMC 1220227. PMID 10229664. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220227.
^ Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar. 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. (GERMANY) 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. ISSN 0014-2980. PMID 10741407.
^ Poinat, Patrice; De Arcangelis Adèle, Sookhareea Satis, Zhu Xiaoping, Hedgecock Edward M, Labouesse Michel, Georges-Labouesse Elisabeth (Apr. 2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Curr. Biol. (England) 12 (8): 622–31. doi:10.1016/S0960-9822(02)00764-9. ISSN 0960-9822. PMID 11967148.
^ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.
^ Fournier, Henri-Noël; Dupé-Manet Sandra, Bouvard Daniel, Lacombe Marie-Lise, Marie Christiane, Block Marc R, Albiges-Rizo Corinne (Jun. 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. (United States) 277 (23): 20895–902. doi:10.1074/jbc.M200200200. ISSN 0021-9258. PMID 11919189.
^ ^a ^b Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (Nov. 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.
^ Parsons, Maddy; Keppler Melanie D, Kline Adam, Messent Anthea, Humphries Martin J, Gilchrist Ruth, Hart Ian R, Quittau-Prevostel Corinne, Hughes William E, Parker Peter J, Ng Tony (Aug. 2002). "Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis". Mol. Cell. Biol. (United States) 22 (16): 5897–911. doi:10.1128/MCB.22.16.5897-5911.2002. ISSN 0270-7306. PMC 133968. PMID 12138200. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133968.
^ Han, D C; Rodriguez L G, Guan J L (Jan. 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene (England) 20 (3): 346–57. doi:10.1038/sj.onc.1204068. ISSN 0950-9232. PMID 11313964.
^ Chang, D D; Wong C, Smith H, Liu J (Sep. 1997). "ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin". J. Cell Biol. (UNITED STATES) 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. ISSN 0021-9525. PMC 2136751. PMID 9281591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2136751.
^ Chang, David D; Hoang Bao Q, Liu Jenny, Springer Timothy A (Mar. 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. (United States) 277 (10): 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908.
^ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.
^ Liliental, J; Chang D D (Jan. 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.

[edit] Further reading

Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". Bioessays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions". Front. Biosci. 7: d219–27. doi:10.2741/armulik. PMID 11779688.
Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more". Cancer Metastasis Rev. 24 (3): 403–11. doi:10.1007/s10555-005-5132-5. PMID 16258728.

[edit] External links

MeSH CD29+Antigen

This immunology article is a stub. You can help Wikipedia by expanding it.

[pmid2524991-0] Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (Jul 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Ann Hum Genet 53 (Pt 1): 15–22. doi:10.1111/j.1469-1809.1989.tb01118.x. PMID 2524991.

[1] "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3688.

[pmid9360996-2] Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (Nov. 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.

[pmid8630057-3] Radford, K J; Thorne R F, Hersey P (May. 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. (UNITED STATES) 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. ISSN 0006-291X. PMID 8630057.

[pmid12175627-4] Mazzocca, Antonio; Carloni Vinicio, Sciammetta Silvia, Cordella Claudia, Pantaleo Pietro, Caldini Anna, Gentilini Paolo, Pinzani Massimo (Sep. 2002). "Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration". J. Hepatol. (England) 37 (3): 322–30. doi:10.1016/S0168-8278(02)00175-7. ISSN 0168-8278. PMID 12175627.

[pmid11807098-5] van der Flier, Arjan; Kuikman Ingrid, Kramer Duco, Geerts Dirk, Kreft Maaike, Takafuta Toshiro, Shapiro Sandor S, Sonnenberg Arnoud (Jan. 2002). "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits". J. Cell Biol. (United States) 156 (2): 361–76. doi:10.1083/jcb.200103037. ISSN 0021-9525. PMC 2199218. PMID 11807098. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199218.

[pmid9722563-6] Loo, D T; Kanner S B, Aruffo A (Sep. 1998). "Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction". J. Biol. Chem. (UNITED STATES) 273 (36): 23304–12. doi:10.1074/jbc.273.36.23304. ISSN 0021-9258. PMID 9722563.

[pmid10229664-7] Serru, V; Le Naour F, Billard M, Azorsa D O, Lanza F, Boucheix C, Rubinstein E (May. 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. (ENGLAND) 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. ISSN 0264-6021. PMC 1220227. PMID 10229664. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220227.

[pmid10741407-8] Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (Mar. 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. (GERMANY) 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. ISSN 0014-2980. PMID 10741407.

[pmid11967148-9] Poinat, Patrice; De Arcangelis Adèle, Sookhareea Satis, Zhu Xiaoping, Hedgecock Edward M, Labouesse Michel, Georges-Labouesse Elisabeth (Apr. 2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Curr. Biol. (England) 12 (8): 622–31. doi:10.1016/S0960-9822(02)00764-9. ISSN 0960-9822. PMID 11967148.

[pmid10906324-10] Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (Oct. 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.

[pmid11919189-11] Fournier, Henri-Noël; Dupé-Manet Sandra, Bouvard Daniel, Lacombe Marie-Lise, Marie Christiane, Block Marc R, Albiges-Rizo Corinne (Jun. 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. (United States) 277 (23): 20895–902. doi:10.1074/jbc.M200200200. ISSN 0021-9258. PMID 11919189.

[pmid12435334-12] Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (Nov. 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.

[pmid12138200-13] Parsons, Maddy; Keppler Melanie D, Kline Adam, Messent Anthea, Humphries Martin J, Gilchrist Ruth, Hart Ian R, Quittau-Prevostel Corinne, Hughes William E, Parker Peter J, Ng Tony (Aug. 2002). "Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis". Mol. Cell. Biol. (United States) 22 (16): 5897–911. doi:10.1128/MCB.22.16.5897-5911.2002. ISSN 0270-7306. PMC 133968. PMID 12138200. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133968.

[pmid11313964-14] Han, D C; Rodriguez L G, Guan J L (Jan. 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene (England) 20 (3): 346–57. doi:10.1038/sj.onc.1204068. ISSN 0950-9232. PMID 11313964.

[pmid9281591-15] Chang, D D; Wong C, Smith H, Liu J (Sep. 1997). "ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin". J. Cell Biol. (UNITED STATES) 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. ISSN 0021-9525. PMC 2136751. PMID 9281591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2136751.

[pmid11741908-16] Chang, David D; Hoang Bao Q, Liu Jenny, Springer Timothy A (Mar. 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. (United States) 277 (10): 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908.

[pmid10852818-17] Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (Jul. 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND) 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.

[pmid9442085-18] Liliental, J; Chang D D (Jan. 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.

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CD29

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