PVRL1

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Poliovirus receptor-related 1 (herpesvirus entry mediator C)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PVRL1 ; CD111; CLPED1; ED4; HIgR; HV1S; HVEC; OFC7; PRR; PRR1; PVRR; PVRR1; SK-12; nectin-1
External IDs OMIM600644 MGI1926483 HomoloGene2138 GeneCards: PVRL1 Gene
RNA expression pattern
PBB GE PVRL1 208455 at tn.png
PBB GE PVRL1 211846 s at tn.png
PBB GE PVRL1 211845 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5818 58235
Ensembl ENSG00000110400 ENSMUSG00000032012
UniProt Q15223 Q9JKF6
RefSeq (mRNA) NM_002855 NM_021424
RefSeq (protein) NP_002846 NP_067399
Location (UCSC) Chr 11:
119.49 – 119.6 Mb
Chr 9:
43.74 – 43.81 Mb
PubMed search [1] [2]

Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1, is a human gene that encodes a protein of immunoglobulin superfamily (IgSF) also considered a member of the nectins.[1] It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediate Ca2+-independent cellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).

PVRL1 is adhesion molecule found in a wide range of tissues where is localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin.

In the chemical synapse PVRL1 interacts with PVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain developmen as well as in aging brains. Inerestingly the two proteins have been found to localize asymmetrically along the chemical synapse, with PVRL1 primarily on the axonal side and PVRL3 on the dendritic side.

The protein has been revealed as one of the key playerse in mediating cellular entry of the Herpes simplex virus by interacting with the viral glycoprotein D (gD).[2]


See also[edit]

Interactions[edit]

PVRL1 has been shown to interact with MLLT4.[3]

References[edit]

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.