CDH17

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Cadherin 17, LI cadherin (liver-intestine)
Identifiers
Symbols CDH17 ; CDH16; HPT-1; HPT1
External IDs OMIM603017 MGI1095414 HomoloGene56859 GeneCards: CDH17 Gene
RNA expression pattern
PBB GE CDH17 209847 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1015 12557
Ensembl ENSG00000079112 ENSMUSG00000028217
UniProt Q12864 Q9R100
RefSeq (mRNA) NM_001144663 NM_019753
RefSeq (protein) NP_001138135 NP_062727
Location (UCSC) Chr 8:
95.14 – 95.23 Mb
Chr 4:
11.76 – 11.82 Mb
PubMed search [1] [2]

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]

References[edit]

  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235. 
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  3. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)". 

Further reading[edit]

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