Carbestrol

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Carbestrol
Clinical data
ATC code
  • None
Identifiers
  • 3-Ethyl-4-(4-methoxyphenyl)-2-methylcyclohex-3-ene-1-carboxylic acid
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H22O3
Molar mass274.35478 g/mol g·mol−1
3D model (JSmol)
  • CCC1=C(CCC(C1C)C(=O)O)C2=CC=C(C=C2)OC
  • InChI=1S/C17H22O3/c1-4-14-11(2)15(17(18)19)9-10-16(14)12-5-7-13(20-3)8-6-12/h5-8,11,15H,4,9-10H2,1-3H3,(H,18,19)
  • Key:VJKVHUZOVAWKEB-UHFFFAOYSA-N

Carbestrol (developmental code names NSC-19962, ORF-2166) is a synthetic, non-steroidal estrogen of the cyclohexenecarboxylic acid group and seco analogue of doisynolic acid that was developed for the treatment of prostate cancer in the 1960s but was never marketed.[1][2][3][4]

See also

References

  1. ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 516–. ISBN 978-1-4757-2085-3.
  2. ^ ARDUINO LJ (1964). "CARBESTROL (NSC-19962) TREATMENT OF PATIENTS WITH PROSTATIC CARCINOMA-PRELIMINARY REPORT". Cancer Chemother Rep. 39: 67–75. PMID 14201278.
  3. ^ Kogler J, Hill G, Sedransk N, Cole DR, Weiss AJ, Wilson W (1972). "Phase II study of carbestrol (NSC-19962) in patients with solid tumors". Cancer Chemother Rep. 56 (5): 641–7. PMID 4652590.
  4. ^ Raymond Eller Kirk; Donald Frederick Othmer (1980). Encyclopedia of chemical technology. Wiley. p. 672. ISBN 978-0-471-02065-3.



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