It has scheduled domestic flights to all islands of the Azores, plus Madeira and the mainland, namely (Lisbon, Porto and Faro). Joao Paulo II Airport also accommodates international flights to and from Europe and North America. The airport is the major hub for the Azorian airline SATA which includes both SATA Air Açores and SATA International and from April 2015 it will also serve as a hub for Ryanair.
Along with the airports in Lisbon, Porto, Faro, Flores, Santa Maria, Horta and Beja, the airport's concessions to provide support to civil aviation was conceded to ANA Aeroportos de Portugal on 18 December 1998, under provisions of decree 404/98. With this concession, ANA was also provided to the planning, development and construction of future infrastructures.