Molsidomine

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Molsidomine
Molsidomine.svg
Names
IUPAC name
1-Ethoxy-N-(3-morpholino-5-oxadiazol-3-iumyl)methanimidate
Identifiers
ATC code C01DX12
25717-80-0 YesY
ChEMBL ChEMBL1256353 N
ChemSpider 4090 YesY
Jmol-3D images Image
KEGG D01320 YesY
PubChem 5353788
Properties
C9H14N4O4
Molar mass 242.23 g/mol
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N verify (what isYesY/N?)
Infobox references

Molsidomine is an orally active, long acting vasodilating drug. Molsidomine is metabolized in the liver to the active metabolite linsidomine. Linsidomine is an unstable compound that releases nitric oxide (NO) upon decay as the actual vasodilating compound.[1]

Release of nitric oxide[edit]

Molsidomine.svgSIN-1.svgSIN-1A chemical structure.svg → NO

Molsidomine → Linsidomine (SIN-1) → SIN-1A → nitric oxide[2]

Chemistry[edit]

Molsidomine as well as linsidomine are sydnone imines, a class of mesoionic heterocyclic aromatic chemical compounds.

See also[edit]

References[edit]

  1. ^ Rosenkranz, B.; Winkelmann, B. R.; Parnham, M. J. (1996). "Clinical pharmacokinetics of molsidomine". Clinical pharmacokinetics 30 (5): 372–384. doi:10.2165/00003088-199630050-00004. PMID 8743336.  edit
  2. ^ Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 558. ISBN 3-8047-1763-2.