Nicorandil
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| Systematic (IUPAC) name | |
| 2-[(pyridin-3-ylcarbonyl)amino]ethyl nitrate | |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Pregnancy cat. | B3 (AU) |
| Legal status | POM (UK) |
| Routes | Oral |
| Pharmacokinetic data | |
| Bioavailability | 75 to 80% |
| Protein binding | 25% |
| Metabolism | Hepatic |
| Half-life | 1 hour |
| Excretion | Renal (21%) |
| Identifiers | |
| CAS number | 65141-46-0  |
| ATC code | C01DX16 |
| PubChem | CID 47528 |
| IUPHAR ligand | 2411 |
| ChemSpider | 43240 |
| UNII | 260456HAM0 |
| KEGG | D01810 |
| ChEMBL | CHEMBL284906 |
| Chemical data | |
| Formula | C8H9N3O4 |
| Mol. mass | 211.175 g/mol |
| SMILES | eMolecules & PubChem |
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Nicorandil is a vasodilatory drug used to treat angina. It is marketed under the trade names Ikorel (in the United Kingdom, Australia and most of Europe), Dancor (in Switzerland), Nikoran (in India), Aprior (in the Philippines), Nitorubin (in Japan) and Sigmart (in Japan, South Korea and Taiwan). Nicorandil is not available in the United States.
It works by opening KATP potassium channels.
[edit] Side effects
Common side effects include flushing, palpitation, weakness, headache, mouth ulcers, nausea and vomiting. More recently, peri-anal, ileal and peri-stomal ulceration has been reported as a side effect. Anal ulceration is now included in the British National Formulary as a reported side effect.
Can also give the feeling of severe toothache, and nasal congestion
[edit] Mechanism of action
Activates a K channel, therefore there is an increased K permeability in various cells. In certain tissue like vascular smooth muscle, this hyperpolarizes the cell membrane, causing the closure of Ca L-type channel, thus reduced intracellular free Ca, thus vasodilation.
[edit] References
- Kukovetz WR, Holzmann S, Pöch G (1992). "Molecular mechanism of action of nicorandil". J. Cardiovasc. Pharmacol. 20 (Suppl 3): S1–7. PMID 1282168.
- Tripathi, K.D. Essentials of Medical Pharmacology, chapter 37, page 499.
- Dr.Hosny Mohaed, Brief ACSs.
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