|Molar mass||123.11 g·mol−1|
|Appearance||White to tan crystalline solid|
|Melting point||136 to 138 °C (277 to 280 °F; 409 to 411 K)|
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
|what is: / ?)(|
Picolinic acid is an organic compound with the formula C5H4N(CO2H). It is a derivative of pyridine with a carboxylic acid substituent at the 2-position. It is an isomer of nicotinic acid, which has the carboxyl side chain at the 3-position. It is a white solid that is soluble in water.
Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body.:72 Many of its complexes are charge-neutral and thus lipophilic. After its role in absorption was discovered, zinc dipicolinate dietary supplements became popular as they were shown to be an effective means of introducing zinc into the body.
- Grant, RS; Coggan, SE; Smythe, GA (2009). "The physiological action of picolinic Acid in the human brain.". International journal of tryptophan research : IJTR 2: 71–9. PMC 3195224. PMID 22084583. Retrieved 22 January 2013.
- Picolinic Acid chapter in Philip L. Fuchs. Handbook of Reagents for Organic Synthesis: Catalytic Oxidation Reagents. John Wiley & Sons, Jul 29, 2013 ISBN 9781118704820
- Grant, R.; Coggan, S.; Smythe, G. (2009). "The Physiological Action of Picolinic Acid in the Human Brain". International Journal of Tryptophan Research (Libertas Academica) 2: 71–79. Retrieved 20 March 2015.
- Tan L et al. The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations. J Neurol Sci. 2012 Dec 15;323(1-2):1-8. PMID 22939820
- Evans, Gary (1982). "The Role of Picolinic Acid in Metal Metabolism". Life Chemistry Reports (Harwood Academic Publishers) 1: 57–67. Retrieved 20 March 2015.