|Jmol-3D images||Image 1|
|Molar mass||123.11 g mol−1|
|Appearance||White to tan crystalline solid|
|Solubility in water||887 g/L|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Picolinic acid is a pyridine compound with a carboxyl side chain at the 2-position. It is an isomer of nicotinic acid, which has the carboxyl side chain at the 3-position. It is a catabolite of the amino acid tryptophan.
Picolinic acid acts as a chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body.  and for the quantitative detection of calcium.
The acid is believed to form a complex with zinc that may facilitate the passage of zinc through the gastrointestinal wall and into the circulatory system. A study of rats found that dietary picolinic acid increases the turnover and excretion of zinc. Other results suggest that picolinic acid is a chelator which interacts with metals aside from zinc. Commercially available picolinic acid is used as an intermediate to produce pharmaceuticals (especially local anesthetics) and metal salts for the application of nutritional supplements.
- Grant, RS; Coggan, SE; Smythe, GA (2009). "The physiological action of picolinic Acid in the human brain.". International journal of tryptophan research : IJTR 2: 71–9. PMC 3195224. PMID 22084583.
- Evans GW, Johnson EC (January 1981). "Effect of iron, vitamin B-6 and picolinic acid on zinc absorption in the rat". J. Nutr. 111 (1): 68–75. PMID 7452375.
- Aggett PJ, Fenwick PK, Kirk H (October 1989). "An in vitro study of the effect of picolinic acid on metal translocation across lipid bilayers". J. Nutr. 119 (10): 1432–7. PMID 2585133.