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Chlorobutanol Structural Formula V.2.svg Chlorobutanol3d.png
CAS number 57-15-8 YesY
ChemSpider 13842993 YesY
KEGG D01942 YesY
ATC code A04AD04
Jmol-3D images Image 1
Molecular formula C4H7Cl3O
Molar mass 177.46 g mol−1
Appearance White solid
Odor Menthol
Melting point 95–99 °C (203–210 °F; 368–372 K)
Boiling point 167 °C (333 °F; 440 K)
Solubility in water Slightly soluble
Solubility in acetone Soluble
Main hazards Xn
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 2: Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury. E.g., chloroform Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. In pure state it's a white, menthol like odor, volatile solid.

Chemical synthesis[edit]

Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide.


In a pure state, the substance is toxic by ingestion (damage to the liver) in excessive doses. If the substance touches the skin it may generate irritation and also it may cause some serious damage to the eye if there's contact.[1]


External links[edit]