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Tetraspanin 6
Symbols TSPAN6 ; T245; TM4SF6; TSPAN-6
External IDs OMIM300191 MGI1926264 HomoloGene20700 GeneCards: TSPAN6 Gene
RNA expression pattern
PBB GE TSPAN6 209108 at tn.png
PBB GE TSPAN6 209109 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7105 56496
Ensembl ENSG00000000003 ENSMUSG00000067377
UniProt O43657 Q99L96
RefSeq (mRNA) NM_001278740 NM_019656
RefSeq (protein) NP_001265669 NP_062630
Location (UCSC) Chr X:
100.63 – 100.64 Mb
Chr X:
133.89 – 133.9 Mb
PubMed search [1] [2]

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene.[2]


  1. ^ Maeda K, Matsuhashi S, Hori K, Xin Z, Mukai T, Tabuchi K, Egashira M, Niikawa N (Dec 1998). "Cloning and characterization of a novel human gene, TM4SF6, encoding a protein belonging to the transmembrane 4 superfamily, and mapped to Xq22". Genomics 52 (2): 240–2. doi:10.1006/geno.1998.5415. PMID 9782095. 
  2. ^ a b "Entrez Gene: TSPAN6 tetraspanin 6". 

Further reading[edit]